MULTISPECIES: N-acetylneuraminate lyase [Enterobacteriaceae].

LOCUS       WP_000224714             297 aa            linear   BCT 03-JUN-2024
ACCESSION   WP_000224714
VERSION     WP_000224714.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 297)
  AUTHORS   Grobe,K., Sartori,B., Traving,C., Schauer,R. and Roggentin,P.
  TITLE     Enzymatic and molecular properties of the Clostridium tertium
            sialidase
  JOURNAL   J Biochem 124 (6), 1101-1110 (1998)
   PUBMED   9832614
REFERENCE   2  (residues 1 to 297)
  AUTHORS   Lilley,G.G., Barbosa,J.A. and Pearce,L.A.
  TITLE     Expression in Escherichia coli of the putative N-acetylneuraminate
            lyase gene (nanA) from Haemophilus influenzae: overproduction,
            purification, and crystallization
  JOURNAL   Protein Expr Purif 12 (3), 295-304 (1998)
   PUBMED   9535696
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00683.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..297
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..297
                     /gene="nanA"
     Protein         1..297
                     /product="N-acetylneuraminate lyase"
                     /EC_number="4.1.3.3"
                     /GO_function="GO:0008747 - N-acetylneuraminate lyase
                     activity [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=32462
     Region          5..297
                     /region_name="nanA"
                     /note="N-acetylneuraminate lyase; TIGR00683"
                     /db_xref="CDD:273217"
     Site            order(11,43,46..48,137,165)
                     /site_type="inhibition"
                     /note="inhibitor site"
                     /db_xref="CDD:188641"
     Site            order(43,46..48,137,165,206)
                     /site_type="active"
                     /db_xref="CDD:188641"
     Site            order(47,52..53,84..85,109..110,117,121,272..273)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:188641"
     Site            165
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:188641"
ORIGIN      
        1 matnlrgvma alltpfdqqq aldkaslrrl vqfniqqgid glyvggstge afvqslsere
       61 qvleivaeea kgkikliahv gcvstaesqq laasakrygf davsavtpfy ypfsfeehcd
      121 hyraiidsad glpmvvynip alsgvkltld qintlvtlpg vgalkqtsgd lyqmeqirre
      181 hpdlvlyngy deifasglla gadggigsty nimgwryqgi vkalkegdiq taqklqtecn
      241 kvidlliktg vfrglktvlh ymdvvsvplc rkpfgpvdek ylpelkalaq qlmqerg