MULTISPECIES: 3-phenylpropionate/cinnamic acid dioxygenase subunit

LOCUS       WP_000211172             453 aa            linear   BCT 04-SEP-2023
            alpha [Enterobacteriaceae].
ACCESSION   WP_000211172
VERSION     WP_000211172.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 453)
  AUTHORS   Diaz,E., Ferrandez,A. and Garcia,J.L.
  TITLE     Characterization of the hca cluster encoding the dioxygenolytic
            pathway for initial catabolism of 3-phenylpropionic acid in
            Escherichia coli K-12
  JOURNAL   J Bacteriol 180 (11), 2915-2923 (1998)
   PUBMED   9603882
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF042946.1
            Evidence Source    :: NCBIFAM
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..453
                     /gene="hcaE"
     Protein         1..453
                     /product="3-phenylpropionate/cinnamic acid dioxygenase
                     subunit alpha"
                     /EC_number="1.14.12.19"
                     /GO_function="GO:0008695 - 3-phenylpropionate dioxygenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019380 - 3-phenylpropionate catabolic
                     process [Evidence IEA]"
                     /calculated_mol_wt=50978
     Region          18..>226
                     /region_name="HcaE"
                     /note="Phenylpropionate dioxygenase or related
                     ring-hydroxylating dioxygenase, large terminal subunit
                     [Inorganic ion transport and metabolism, General function
                     prediction only]; COG4638"
                     /db_xref="CDD:443676"
     Region          184..433
                     /region_name="RHO_alpha_C_NDO-like"
                     /note="C-terminal catalytic domain of the oxygenase alpha
                     subunit of naphthalene 1,2-dioxygenase (NDO) and related
                     aromatic ring hydroxylating dioxygenases; cd08881"
                     /db_xref="CDD:176890"
     Site            order(189..196,219..220,355,358..359,364,366,369..370,
                     372..373,376)
                     /site_type="other"
                     /note="beta subunit interface [polypeptide binding]"
                     /db_xref="CDD:176890"
     Site            order(205..206,210,212..213,217,373..375,377..378,
                     380..387,390..396,418)
                     /site_type="other"
                     /note="alpha subunit interface [polypeptide binding]"
                     /db_xref="CDD:176890"
     Site            order(206..207,210..211,213..214,218,304,306,316,361,367,
                     371)
                     /site_type="active"
                     /db_xref="CDD:176890"
     Site            order(206..207,210..211,213..214,218,304,306,316,361,367)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:176890"
     Site            order(213,218,371)
                     /site_type="other"
                     /note="Fe binding site [ion binding]"
                     /db_xref="CDD:176890"
ORIGIN      
        1 mttpsdlniy qlidtqngrv tpriytdpdi yqlelerifg rcwlflahes qipkpgdffn
       61 tymgedavvv vrqkdgsika flnqcrhram rvsyadcgnt raftcpyhgw sygingelid
      121 vplepraypq glckshwgln evpcvesykg lifgnwdtsa pglrdylgdi awyldgmldr
      181 reggteivgg vqkwvincnw kfpaeqfasd qyhalfshas avqvlgakdd gsdkrlgdgq
      241 tarpvwetak dalqfgqdgh gsgffftekp danvwvdgav ssyyretyae aeqrlgevra
      301 lrlaghnnif ptlswlngta tlrvwhprgp dqvevwafci tdkaasdevk aafensatra
      361 fgpagfleqd dsenwceiqk llkghrarns klclemglgq ekrrddgipg itnyifseta
      421 argmyqrwad llsseswqev ldktaayqqe vmk