MFS transporter [Escherichia coli].

LOCUS       WP_000204825             466 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_000204825
VERSION     WP_000204825.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 466)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 466)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 466)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
REFERENCE   4  (residues 1 to 466)
  AUTHORS   Yan,N.
  TITLE     Structural advances for the major facilitator superfamily (MFS)
            transporters
  JOURNAL   Trends Biochem Sci 38 (3), 151-159 (2013)
   PUBMED   23403214
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13023745
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     Protein         1..466
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=51256
     Region          25..449
                     /region_name="MFS_MelB_like"
                     /note="Salmonella enterica Na+/melibiose symporter MelB
                     and similar transporters of the Major Facilitator
                     Superfamily; cd17332"
                     /db_xref="CDD:340890"
     Site            order(35..36,39..40,43,76,137..138,140..142,145,166,
                     169..170,173,252,255..256,259..261,264,293,297,349..350,
                     354,358,381,384..385,388..389,392)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340890"
ORIGIN      
        1 mtstpittad iakgkiddal svrekigygl gdaggtvitc limnfltffy tdvfgltpal
       61 vgtlfialrv fdaisdpvmg viadrtqsrw grfrpwqlwi aipigiigil tftvpdasmg
      121 vkiawafgty lllsvgytai nvpycarint mttrhnevis cqswrfvlcg vagflvsvgl
      181 pwmvalfgqg naargyqlgv gvlcaiavvm flccffwvre rvplstmgkf tlrehlaglr
      241 nndqlllmlv msfllinvfn irgggymyfi tyvlqgstgy tslfftmvtf asiigsvivs
      301 pltrrfdtvk iyyytnllla alavlmwflp sgpayqtlwl avilgngvil gftlplhfsl
      361 mafaddygew kthvrssgmn fafnlffikl awassagiis llfifvayqp gvenqtassl
      421 ggiaametll palfhlllag airfcklnnp mmsriatdlr qrhvqp