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LOCUS WP_000201080 335 aa linear BCT 29-MAR-2023 [Salmonella]. ACCESSION WP_000201080 VERSION WP_000201080.1 KEYWORDS RefSeq. SOURCE Salmonella ORGANISM Salmonella Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae. REFERENCE 1 (residues 1 to 335) AUTHORS Bondos,S.E., Swint-Kruse,L. and Matthews,K.S. TITLE Flexibility and Disorder in Gene Regulation: LacI/GalR and Hox Proteins JOURNAL J Biol Chem 290 (41), 24669-24677 (2015) PUBMED 26342073 REFERENCE 2 (residues 1 to 335) AUTHORS Swint-Kruse,L. and Matthews,K.S. TITLE Allostery in the LacI/GalR family: variations on a theme JOURNAL Curr Opin Microbiol 12 (2), 129-137 (2009) PUBMED 19269243 COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: Conserved Domain (CDD) Evidence Accession :: Domain architecture ID 11265705 Evidence Source :: NCBI SPARCLE ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..335 /organism="Salmonella" /db_xref="taxon:590" Protein 1..335 /product="LacI family DNA-binding transcriptional regulator" /GO_function="GO:0000976 - transcription cis-regulatory region binding [Evidence IEA]" /GO_function="GO:0003700 - DNA-binding transcription factor activity [Evidence IEA]" /GO_function="GO:0043565 - sequence-specific DNA binding [Evidence IEA]" /GO_process="GO:0006351 - DNA-templated transcription [Evidence IEA]" /GO_process="GO:0006355 - regulation of DNA-templated transcription [Evidence IEA]" /GO_process="GO:0045892 - negative regulation of DNA-templated transcription [Evidence IEA]" /calculated_mol_wt=37119 Region 2..71 /region_name="HTH_LACI" /note="helix_turn _helix lactose operon repressor; smart00354" /db_xref="CDD:197675" Site order(5,13..17,19..20,23,28..29,32,45,48,51..52,54..55) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:143331" Site 45..54 /site_type="active" /note="domain linker motif [active]" /db_xref="CDD:143331" Region 61..327 /region_name="PBP1_GalS-like" /note="ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; cd06270" /db_xref="CDD:380494" Site order(61,68,74,79,82,91..94,96,110,114,221..222,254, 280..281) /site_type="other" /note="dimer interface (closed form) [polypeptide binding]" /db_xref="CDD:380494" Site order(73,122,194,219,245,273) /site_type="other" /note="ligand binding site [chemical binding]" /db_xref="CDD:380494" ORIGIN 1 matikdvasm agvstatvsr vinqtawvep vtrervekam rdlnyrrnaa aialakrsgd 61 mlglltgnla dpffarlarg vedvsrkqqy rlmvcsgghd eemekagldf lvnqgceaiv 121 vhasrlpdke llryaahfpa lvvvnryiag manrciwlen rsaareatry llanghrria 181 cvtsdlpiid rqerldgyre aleeygispd prwvisvpfn eeggeraahq linsglplta 241 avtfndvmaa gimrilhqrg vqlpqqlsiv gfddvvlary lypalttmhy pveqmarcaa 301 qlaiqlyqgi tpppssnhfn aelvirdsva pyfsr