MFS transporter [Escherichia coli].

LOCUS       WP_000194233             452 aa            linear   BCT 24-DEC-2024
ACCESSION   WP_000194233
VERSION     WP_000194233.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 452)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 452)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 452)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
REFERENCE   4  (residues 1 to 452)
  AUTHORS   Yan,N.
  TITLE     Structural advances for the major facilitator superfamily (MFS)
            transporters
  JOURNAL   Trends Biochem Sci 38 (3), 151-159 (2013)
   PUBMED   23403214
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13024277
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     Protein         1..452
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=48329
     Region          24..430
                     /region_name="MFS_PcaK_like"
                     /note="4-hydroxybenzoate transporter PcaK and similar
                     transporters of the Major Facilitator Superfamily;
                     cd17365"
                     /db_xref="CDD:340923"
     Site            order(34..35,38..39,42,74,124..125,127..129,132,152,
                     155..156,159,263,266..267,270..272,275,302,306,356..357,
                     361,365,381,384..385,388..389,392)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340923"
ORIGIN      
        1 mtqrrdlqal idaapvgkmq wrviiccflv vmldgfdtaa igfiapdirt hwqltagdla
       61 plfgagllgl tagallcgpl sdrfgrkrvi elcvflfgal slasafspdl qtlvflrflt
      121 glglggampn titmtseylp arrrgalvtl mfcgftlgsa fggivsaqlv pvigwhgilv
      181 lggvlplmlf vallvvlpes prwqvrrqlp qaviaktvsa itreryvdth fyliesasvt
      241 kgsirqlfmg rqlpitlmlw vvffmsllii yllsswmptl lnhrgidlqh aswvtaafqi
      301 ggtlgalalg vlmdkfnpfr vltlsyaiga icivmiglsq dglwlmalai fgtgigisgs
      361 qvglnaltat lyptqsratg vswsnaigrc gaivgslsgg vmmamnfsfd tlffiiavpa
      421 aisavmltll itvvrqstsv pdslpragvv ne