MULTISPECIES: lambda exonuclease family protein [Escherichia].

LOCUS       WP_000186844             226 aa            linear   BCT 19-FEB-2025
ACCESSION   WP_000186844
VERSION     WP_000186844.1
KEYWORDS    RefSeq.
SOURCE      Escherichia
  ORGANISM  Escherichia
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 226)
  AUTHORS   Steczkiewicz,K., Muszewska,A., Knizewski,L., Rychlewski,L. and
            Ginalski,K.
  TITLE     Sequence, structure and functional diversity of PD-(D/E)XK
            phosphodiesterase superfamily
  JOURNAL   Nucleic Acids Res 40 (15), 7016-7045 (2012)
   PUBMED   22638584
REFERENCE   2  (residues 1 to 226)
  AUTHORS   Zhang,J., McCabe,K.A. and Bell,C.E.
  TITLE     Crystal structures of lambda exonuclease in complex with DNA
            suggest an electrostatic ratchet mechanism for processivity
  JOURNAL   Proc Natl Acad Sci U S A 108 (29), 11872-11877 (2011)
   PUBMED   21730170
REFERENCE   3  (residues 1 to 226)
  AUTHORS   Kovall,R. and Matthews,B.W.
  TITLE     Toroidal structure of lambda-exonuclease
  JOURNAL   Science 277 (5333), 1824-1827 (1997)
   PUBMED   9295273
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 16909715
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..226
                     /organism="Escherichia"
                     /db_xref="taxon:561"
     Protein         1..226
                     /product="lambda exonuclease family protein"
                     /EC_number="3.1.11.3"
                     /GO_function="GO:0004527 - exonuclease activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /calculated_mol_wt=25753
     Region          18..207
                     /region_name="PDDEXK_lambda_exonuclease-like"
                     /note="Uncharacterized nucleases similar to lambda phage
                     exonuclease; cd22343"
                     /db_xref="CDD:411747"
     Site            order(85,119,129,131)
                     /site_type="active"
                     /db_xref="CDD:411747"
ORIGIN      
        1 mtpdiilqrt gidvraveqg ddawhklrlg vitasevhnv iakprsgkkw pdmkmsyfht
       61 llaevctgva pevnakalaw gkqyendart lfeftsgvnv tespiiyrde smrtacspdg
      121 lcsdgnglel kcpftsrdfm kfrlggfeai ksaymaqvqy smwvtrkdaw yfanydprmk
      181 reglhyvvve rdekymagfd emvpefiekm dealaeigfv fgeqwr