MULTISPECIES: orotidine-5'-phosphate decarboxylase [Shigella].

LOCUS       WP_000176258             245 aa            linear   BCT 17-NOV-2023
ACCESSION   WP_000176258
VERSION     WP_000176258.1
KEYWORDS    RefSeq.
SOURCE      Shigella
  ORGANISM  Shigella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 245)
  AUTHORS   Lee,T.S., Chong,L.T., Chodera,J.D. and Kollman,P.A.
  TITLE     An alternative explanation for the catalytic proficiency of
            orotidine 5'-phosphate decarboxylase
  JOURNAL   J. Am. Chem. Soc. 123 (51), 12837-12848 (2001)
   PUBMED   11749542
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF001273.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK00230
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..245
                     /organism="Shigella"
                     /db_xref="taxon:620"
     gene            1..245
                     /gene="pyrF"
     Protein         1..245
                     /product="orotidine-5'-phosphate decarboxylase"
                     /EC_number="4.1.1.23"
                     /GO_function="GO:0004590 - orotidine-5'-phosphate
                     decarboxylase activity [Evidence IEA]"
                     /GO_process="GO:0006207 - 'de novo' pyrimidine nucleobase
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0044205 - 'de novo' UMP biosynthetic
                     process [Evidence IEA]"
                     /calculated_mol_wt=26164
     Region          13..243
                     /region_name="PRK00230"
                     /note="orotidine-5'-phosphate decarboxylase"
                     /db_xref="CDD:234695"
     Site            order(20,22,44,46,71,73,130..131,189,221..222)
                     /site_type="active"
                     /db_xref="CDD:240076"
     Site            order(46,48..49,72..73,75..76,79..80,83..84,99..101,112,
                     130,150,222)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:240076"
ORIGIN      
        1 mtltassssr avtnspvvva ldyhncddal sfvdkidprd crlkvgkemf tlfgpqfvre
       61 lqqrgfdifl dlkfhdipnt aahavaaaad lgvwmvnvha sggarmmtaa realvpfgkd
      121 aplliavtvl tsmeasdlad lgvtlspady aerlaaltqk cdldgvvcsa qeavrfkqvf
      181 gqefklvtpg irpqgseagd qrrimtpeqa laagvdymvi grpvtqsvdp aqtlkainas
      241 lqrsa