MULTISPECIES: GDP-mannose 4,6-dehydratase [Escherichia].

LOCUS       WP_000169624             372 aa            linear   BCT 01-JUL-2024
ACCESSION   WP_000169624
VERSION     WP_000169624.1
KEYWORDS    RefSeq.
SOURCE      Escherichia
  ORGANISM  Escherichia
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 372)
  AUTHORS   Sullivan,F.X., Kumar,R., Kriz,R., Stahl,M., Xu,G.Y., Rouse,J.,
            Chang,X.J., Boodhoo,A., Potvin,B. and Cumming,D.A.
  TITLE     Molecular cloning of human GDP-mannose 4,6-dehydratase and
            reconstitution of GDP-fucose biosynthesis in vitro
  JOURNAL   J Biol Chem 273 (14), 8193-8202 (1998)
   PUBMED   9525924
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR01472.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..372
                     /organism="Escherichia"
                     /db_xref="taxon:561"
     gene            1..372
                     /gene="gmd"
     Protein         1..372
                     /product="GDP-mannose 4,6-dehydratase"
                     /EC_number="4.2.1.47"
                     /GO_function="GO:0008446 - GDP-mannose 4,6-dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0000271 - polysaccharide biosynthetic
                     process [Evidence IEA]"
                     /GO_process="GO:0019673 - GDP-mannose metabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=41543
     Region          3..355
                     /region_name="Gmd"
                     /note="GDP-D-mannose dehydratase [Cell
                     wall/membrane/envelope biogenesis]; COG1089"
                     /db_xref="CDD:440706"
ORIGIN      
        1 mtkvalitgv tgqdgsylae flldkgyevh gikrrassfn teridhiyqd phgsnpnfhl
       61 hygdltdssn ltrilkevqp devynlaams hvavsfespe ytadvdaigt lrlleairfl
      121 glenktrfyq astselyglv qeipqkestp fyprspyava klyaywitvn yresygiyac
      181 ngilfnhesp rrgetfvtrk itrglaniaq glesclylgn mdslrdwgha kdyvrmqwlm
      241 lqqeqpedfv iatgvqysvr qfvemaaaql gikmsfvgkg ieekgivdsv egqdapgvkp
      301 gdvivavdpr yfrpaevdtl lgdpskanlk lgwrpeitla emisemvakd leaakkhsll
      361 kshgfsvsla le