MFS transporter [Escherichia coli].

LOCUS       WP_000165714             394 aa            linear   BCT 22-JUL-2024
ACCESSION   WP_000165714
VERSION     WP_000165714.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 394)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 394)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13023516
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..394
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     Protein         1..394
                     /product="MFS transporter"
                     /GO_component="GO:0005886 - plasma membrane [Evidence
                     IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=41523
     Region          13..384
                     /region_name="MFS_NepI_like"
                     /note="Purine ribonucleoside efflux pump NepI and similar
                     transporters of the Major Facilitator Superfamily;
                     cd17324"
                     /db_xref="CDD:340882"
     Site            order(23..24,27..28,31,63,113,115..117,120,140,143..144,
                     147,220,223..224,227..229,232,260,264,314..315,319,323,
                     338,341..342,345..346,349)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340882"
ORIGIN      
        1 mtkpnhelsp alivlmsiat glavasnyya qplldtiarn fslsassagf ivtaaqlgya
       61 agllflvplg dmferrrliv smtllaaggm litassqsla mmilgtaltg lfsvvaqilv
      121 plaatlaspd krgkvvgtim sglllgilla rtvagllanl ggwrtvfwva svlmalmala
      181 lwrglpqmks ethlnypqll gsvfsmfisn kilrtrallg cltfanfsil wtsmafllaa
      241 ppfnysdgvi glfglagaag algarpaggf adkgkshhtt tfglllllls wlaiwfghts
      301 vlaliigilv ldltvqgvhi tnqtviyrih pdarnrltag ymtsyfigga agslisasaw
      361 qhggwagvcl agatialvnl lvwwrgfhrq eaan