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tyrosine-protein kinase Wzc [Escherichia coli].


LOCUS       WP_000137171             720 aa            linear   BCT 11-DEC-2019
ACCESSION   WP_000137171
VERSION     WP_000137171.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 720)
  AUTHORS   Collins,R.F., Beis,K., Dong,C., Botting,C.H., McDonnell,C.,
            Ford,R.C., Clarke,B.R., Whitfield,C. and Naismith,J.H.
  TITLE     The 3D structure of a periplasm-spanning platform required for
            assembly of group 1 capsular polysaccharides in Escherichia coli
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 104 (7), 2390-2395 (2007)
   PUBMED   17283336
REFERENCE   2  (residues 1 to 720)
  AUTHORS   Grangeasse,C., Obadia,B., Mijakovic,I., Deutscher,J., Cozzone,A.J.
            and Doublet,P.
  TITLE     Autophosphorylation of the Escherichia coli protein kinase Wzc
            regulates tyrosine phosphorylation of Ugd, a UDP-glucose
            dehydrogenase
  JOURNAL   J. Biol. Chem. 278 (41), 39323-39329 (2003)
   PUBMED   12851388
REFERENCE   3  (residues 1 to 720)
  AUTHORS   Nakar,D. and Gutnick,D.L.
  TITLE     Involvement of a protein tyrosine kinase in production of the
            polymeric bioemulsifier emulsan from the oil-degrading strain
            Acinetobacter lwoffii RAG-1
  JOURNAL   J. Bacteriol. 185 (3), 1001-1009 (2003)
   PUBMED   12533476
REFERENCE   4  (residues 1 to 720)
  AUTHORS   Paiment,A., Hocking,J. and Whitfield,C.
  TITLE     Impact of phosphorylation of specific residues in the tyrosine
            autokinase, Wzc, on its activity in assembly of group 1 capsules in
            Escherichia coli
  JOURNAL   J. Bacteriol. 184 (23), 6437-6447 (2002)
   PUBMED   12426330
REFERENCE   5  (residues 1 to 720)
  AUTHORS   Doublet,P., Grangeasse,C., Obadia,B., Vaganay,E. and Cozzone,A.J.
  TITLE     Structural organization of the protein-tyrosine autokinase Wzc
            within Escherichia coli cells
  JOURNAL   J. Biol. Chem. 277 (40), 37339-37348 (2002)
   PUBMED   12138098
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF008568.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK11519
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..720
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     gene            1..720
                     /gene="wzc"
     Protein         1..720
                     /product="tyrosine-protein kinase Wzc"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0009103 - lipopolysaccharide biosynthetic
                     process [Evidence IEA]"
                     /calculated_mol_wt=79264
     Region          1..719
                     /region_name="PRK11519"
                     /note="tyrosine-protein kinase Wzc"
                     /db_xref="CDD:183173"
     Site            order(508,511..512,514..516,536,564,566..567,609,618,621,
                     644..645,647..650,653..654,657,669..670,672,674..675,678,
                     682,685..686)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:349772"
     Site            order(537..542,564,569,642,696)
                     /site_type="active"
                     /db_xref="CDD:349772"
ORIGIN      
        1 mtekvkqhaa pvtgsdeidi grlvgtviea rwwvigitav falcavvytf fatpiysada
       61 lvqieqssgn slvqdigsal ankppasdae iqlirsrlvl gktvddldld iavskntfpi
      121 fgagwdrlmg rqnetvkvtt fnrpkemedq vftlnvldnk nytlssdggf sargqagqil
      181 kkegvtlmve aiharpgsef tvtkystlgm inqlqnsltv tengkdagvl sltytgedre
      241 qirdilnsia rnyqeqnier ksaeasksla flaqqlpevr srldvaenkl nafrqdkdsv
      301 dlpleakavl dsmvnidaql neltfkeaei sklytkvhpa yrtllekrqa ledekaklng
      361 rvtampktqq eivrltrdve sgqqvymqll nkeqelkite astvgdvriv dpaitqpgvl
      421 kpkkgliilg aiilglmlsi vgvllrslfn rgiespqvle ehgisvyasi plsewqkard
      481 svktikgikr ykqsqllavg nptdlaieai rslrtslhfa mmqaqnnvlm mtgvspsigk
      541 tfvcanlaav isqtnkrvll idcdmrkgyt hellgtnnvn glseiligqg dittaakpts
      601 iakfdliprg qvppnpsell mserfaelvn wasknydlvl idtppilavt daaivgrhvg
      661 ttlmvaryav ntlkevetsl srfeqngipv kgvilnsifr rasayqdygy yeyeyksdak