MULTISPECIES: multidrug effflux MFS transporter [Escherichia].

LOCUS       WP_000135022             387 aa            linear   BCT 19-FEB-2024
ACCESSION   WP_000135022
VERSION     WP_000135022.1
KEYWORDS    RefSeq.
SOURCE      Escherichia
  ORGANISM  Escherichia
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 387)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 387)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022939
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..387
                     /organism="Escherichia"
                     /db_xref="taxon:561"
     Protein         1..387
                     /product="multidrug effflux MFS transporter"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=41289
     Region          9..382
                     /region_name="MFS_MdfA_MDR_like"
                     /note="Multidrug transporter MdfA and similar multidrug
                     resistance (MDR) transporters of the Major Facilitator
                     Superfamily; cd17320"
                     /db_xref="CDD:340878"
     Site            order(19..20,23..24,48,51..52,109,140,143..144,223,226,
                     344)
                     /site_type="other"
                     /note="chemical substrate binding pocket [chemical
                     binding]"
                     /db_xref="CDD:340878"
ORIGIN      
        1 marvslswal ilgllagigp mctdlylpal pemseqlaat ttitqltlta sliglgvgql
       61 lfgplsdkig rkrplilsll lfivssilca ttnniywlvv wrfiqgiaga ggsvlsrsia
      121 rdkyqgvtlt qffallmtvn glapvlspvl ggyivstfdw rtlfwvmaei stvlllgcvl
      181 finetlpenk rgssllltgr svvqnrrfmr fcliqsfmla glfayigsss fvlqkefgfs
      241 pmqfslvfgl ngigliiasw ifsrlarrin amtllrggli aailcalltv lcawtqlpip
      301 alvalfftia fcsgigtvgg aeamsavgtq esgtasalmg msmfvfggia aplsgfgget
      361 llkmslaitv cytlaflval tridnqk