MULTISPECIES: MFS transporter [Escherichia].

LOCUS       WP_000100890             429 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_000100890
VERSION     WP_000100890.1
KEYWORDS    RefSeq.
SOURCE      Escherichia
  ORGANISM  Escherichia
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 429)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 429)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 429)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022908
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..429
                     /organism="Escherichia"
                     /db_xref="taxon:561"
     Protein         1..429
                     /product="MFS transporter"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=46163
     Region          14..415
                     /region_name="MFS_ExuT_GudP_like"
                     /note="Hexuronate transporter, Glucarate transporter, and
                     similar transporters of the Major Facilitator Superfamily;
                     cd17319"
                     /db_xref="CDD:340877"
     Site            order(28..29,32..33,36,68,118..119,121..123,126,146,
                     149..150,153,247,250..251,254..256,259,288,292,341..342,
                     346,350,366,369..370,373..374,377)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340877"
ORIGIN      
        1 mstalldavv kknrvrlipf mlalyvlafl drsnigfakq tyqidtglsn eayalgagif
       61 fvvyaflgvp anllmrklga rtwigtttll wgflsaamaw adteakfliv rtllraaeag
      121 ffpgmiylts qwfpqrnras imglfymgap laltlgspls gallemhgfm ghpgwfwmfv
      181 iegllavgag vftffwlddt peqarflskq ektllinqla seeqqkvtsr lsdalrngrv
      241 wqlaiiylti qvavygliff lptqvaallg tkvgftasvv taipwvaalf gtwliprysd
      301 ktgerrnvaa ltllaagigi glsgllspvm aivalcvaai gfiavqpvfw tmptqllsgt
      361 alaagigfvn lfgavggfia pilrvkaetl fasdaagllt laavavigsl iiftlrvnrt
      421 vaqtdvahh