MULTISPECIES: NADPH-dependent 7-cyano-7-deazaguanine reductase QueF

LOCUS       WP_000100474             282 aa            linear   BCT 28-FEB-2022
            [Salmonella].
ACCESSION   WP_000100474
VERSION     WP_000100474.1
KEYWORDS    RefSeq.
SOURCE      Salmonella
  ORGANISM  Salmonella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 282)
  AUTHORS   Kim,Y., Zhou,M., Moy,S., Morales,J., Cunningham,M.A. and
            Joachimiak,A.
  TITLE     High-resolution structure of the nitrile reductase QueF combined
            with molecular simulations provide insight into enzyme mechanism
  JOURNAL   J Mol Biol 404 (1), 127-137 (2010)
   PUBMED   20875425
REFERENCE   2  (residues 1 to 282)
  AUTHORS   Van Lanen,S.G., Reader,J.S., Swairjo,M.A., de Crecy-Lagard,V.,
            Lee,B. and Iwata-Reuyl,D.
  TITLE     From cyclohydrolase to oxidoreductase: discovery of nitrile
            reductase activity in a common fold
  JOURNAL   Proc Natl Acad Sci U S A 102 (12), 4264-4269 (2005)
   PUBMED   15767583
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR03138.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..282
                     /organism="Salmonella"
                     /db_xref="taxon:590"
     gene            1..282
                     /gene="queF"
     Protein         1..282
                     /product="NADPH-dependent 7-cyano-7-deazaguanine reductase
                     QueF"
                     /EC_number="1.7.1.13"
                     /GO_function="GO:0033739 - preQ1 synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0043867 - 7-cyano-7-deazaguanine
                     tRNA-ribosyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0008616 - queuosine biosynthetic process
                     [Evidence IEA]"
                     /note="Catalyzes the NADPH-dependent reduction of
                     7-cyano-7-deazaguanine (preQ0) to
                     7-aminomethyl-7-deazaguanine (preQ1) in queuosine
                     biosynthesis"
                     /calculated_mol_wt=32542
     Region          9..282
                     /region_name="queF"
                     /note="7-cyano-7-deazaguanine reductase; Provisional;
                     PRK11792"
                     /db_xref="CDD:236986"
ORIGIN      
        1 mssyenhqal dgltlgkstd yrdnydvsll qgvprslnrd plgltadnlp fhgadiwtly
       61 elswlnsqgl pqvavghvel dytsvnlies ksfklylnsf nqtrfdtwet vrqtlerdlr
      121 acaqgnvsvr lhrldelegq pvahfhgtci ddqdisidny qfttdylqha vsgekqveet
      181 lvshllksnc lithqpdwgs iqiqyrgrki drekllrylv sfrhhnefhe qcverifndi
      241 lrfcqpetls vyarytrrgg ldinpwrsnt dfvpatgrla rq