MULTISPECIES: MFS transporter [Salmonella].

LOCUS       WP_000099996             457 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_000099996
VERSION     WP_000099996.1
KEYWORDS    RefSeq.
SOURCE      Salmonella
  ORGANISM  Salmonella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 457)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 457)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 457)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
REFERENCE   4  (residues 1 to 457)
  AUTHORS   Yan,N.
  TITLE     Structural advances for the major facilitator superfamily (MFS)
            transporters
  JOURNAL   Trends Biochem Sci 38 (3), 151-159 (2013)
   PUBMED   23403214
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13023745
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Salmonella"
                     /db_xref="taxon:590"
     Protein         1..457
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=50090
     Region          21..422
                     /region_name="MFS_MelB_like"
                     /note="Salmonella enterica Na+/melibiose symporter MelB
                     and similar transporters of the Major Facilitator
                     Superfamily; cd17332"
                     /db_xref="CDD:340890"
     Site            order(31..32,35..36,39,72,133..134,136..138,141,162,
                     165..166,169,250,253..254,257..259,262,289,293,342..343,
                     347,351,374,378..379,382..383,386)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340890"
ORIGIN      
        1 mssviedtqp sgsaslsllq risygsldva gnllycfsst yilyfytdva gislavagvi
       61 lllariidgi dapiwgiiid ktrsrygkcr pwflwlplpf avfsalsfws pdismtgkai
      121 yaaisymias ilftglntpl sailplmtls pkerlvlnsw rmtggqigvl lmnatalplv
      181 aflgngddha gfiytaitfa iiscaltlfa fkniremdtd kiqhepklpm kksfaamkgn
      241 wpwilmvlan lifwialqqr nttivyylty nldrkdlvpl inslatiqil fiiaipffsk
      301 ylaktwiwvg gllvatfggv mmwlaadnit fliaawilgn igsgiacsmp famlgfavdf
      361 gawktgikat giliafgstf cikmgsglgt afaawimnsf gyvpnhaqsa aglegiiwaf
      421 iwapallfal aaipllffrk yeameekirh dletvns