MULTISPECIES: glucarate dehydratase [Enterobacteriaceae].

LOCUS       WP_000098255             446 aa            linear   BCT 16-DEC-2020
ACCESSION   WP_000098255
VERSION     WP_000098255.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 446)
  AUTHORS   Gulick,A.M., Hubbard,B.K., Gerlt,J.A. and Rayment,I.
  TITLE     Evolution of enzymatic activities in the enolase superfamily:
            identification of the general acid catalyst in the active site of
            D-glucarate dehydratase from Escherichia coli
  JOURNAL   Biochemistry 40 (34), 10054-10062 (2001)
   PUBMED   11513584
REFERENCE   2  (residues 1 to 446)
  AUTHORS   Hubbard,B.K., Koch,M., Palmer,D.R., Babbitt,P.C. and Gerlt,J.A.
  TITLE     Evolution of enzymatic activities in the enolase superfamily:
            characterization of the (D)-glucarate/galactarate catabolic pathway
            in Escherichia coli
  JOURNAL   Biochemistry 37 (41), 14369-14375 (1998)
   PUBMED   9772162
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR03247.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..446
                     /gene="gudD"
     Protein         1..446
                     /product="glucarate dehydratase"
                     /EC_number="4.2.1.40"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008872 - glucarate dehydratase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019394 - glucarate catabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=49010
     Region          5..446
                     /region_name="glucar-dehydr"
                     /note="glucarate dehydratase; TIGR03247"
                     /db_xref="CDD:211799"
ORIGIN      
        1 mssqfttpvv temqvipvag hdsmlmnlsg ahapfftrni viikdnsght gvgeipggek
       61 irktledaip lvvgktlgey knvltlvrnt fadrdaggrg lqtfdlrtti hvvtgieaam
      121 ldllgqhlgv nvasllgdgq qrsevemlgy lffvgnrkat plpyqsqpdd scdwyrlrhe
      181 eamtpdavvr laeaayekyg fndfklkggv lageeeaesi valaqrfpqa ritldpngaw
      241 slneaikigk ylkgslayae dpcgaeqgfs grevmaefrr atglptatnm iatdwrqmgh
      301 tlslqsvdip ladphfwtmq gsvrvaqmch efgltwgshs nnhfdislam fthvaaaapg
      361 kitaidthwi wqegnqrltk epfeikgglv qvpekpglgv eidmdqvmka helyqkhglg
      421 arddamgmqy lipgwtfdnk rpcmvr