MULTISPECIES: MFS transporter [Enterobacteriaceae].

LOCUS       WP_000091829             417 aa            linear   BCT 22-JUL-2024
ACCESSION   WP_000091829
VERSION     WP_000091829.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 417)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 417)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13023516
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     Protein         1..417
                     /product="MFS transporter"
                     /GO_component="GO:0005886 - plasma membrane [Evidence
                     IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=45113
     Region          38..409
                     /region_name="MFS_NepI_like"
                     /note="Purine ribonucleoside efflux pump NepI and similar
                     transporters of the Major Facilitator Superfamily;
                     cd17324"
                     /db_xref="CDD:340882"
     Site            order(48..49,52..53,56,88,138..139,141..143,146,166,
                     169..170,173,247,250..251,254..256,259,287,291,339..340,
                     344,348,363,366..367,370..371,374)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340882"
ORIGIN      
        1 msrtttvdga pasdtdkqsi sqpnqfikrg tpqfmrvtla lfsaglatfa llycvqpilp
       61 vlsqefgltp anssislsis tamlaigllf tgplsdaigr kpvmvtalll asictllstm
      121 mtswhgilim raliglslsg vaavgmtyls eeihpsfvaf smglyisgns iggmsgrlis
      181 gvftdffnwr ialaaigcfa lasalmfwki lpesrhfrpt slrpkslfin frlhwrdrgl
      241 pllfaegfll mgsfvtlfny igyrlmlspw hvsqavvgll slayltgtws spkagtmttr
      301 ygrgpvmlfs tgvmlfgllm tlfsslwlif agmllfsagf faahsvassw igprakrakg
      361 qasslylfsy ylgssiagtl ggvfwhnygw ngvgafialm lviallvgtr lhrrlha