MULTISPECIES: 2-isopropylmalate synthase [Enterobacteriaceae].

LOCUS       WP_000082847             523 aa            linear   BCT 30-DEC-2022
ACCESSION   WP_000082847
VERSION     WP_000082847.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF002084.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK00915
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..523
                     /gene="leuA"
     Protein         1..523
                     /product="2-isopropylmalate synthase"
                     /EC_number="2.3.3.13"
                     /GO_function="GO:0003852 - 2-isopropylmalate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019752 - carboxylic acid metabolic
                     process [Evidence IEA]"
                     /calculated_mol_wt=57183
     Region          1..512
                     /region_name="PRK00915"
                     /note="2-isopropylmalate synthase; Validated"
                     /db_xref="CDD:234864"
     Site            order(13..14,17,44,75,97,139,141,169,171,202,204)
                     /site_type="active"
                     /db_xref="CDD:163678"
     Site            order(13..14,44)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:163678"
     Site            order(202,204)
                     /site_type="metal-binding"
                     /note="metal binding site [ion binding]"
                     /db_xref="CDD:163678"
ORIGIN      
        1 msqqviifdt tlrdgeqalq aslsvkeklq ialalermgv dvmevgfpvs spgdfesvqt
       61 iarqvknsrv calarcvekd idvaaeslkv aeafrihtfi atspmhiatk lrstldevie
      121 raiymvkrar nytddvefsc edagrtpiad larvveaain agattinipd tvgytmpfef
      181 agiisglyer vpnidkaiis vhthddlgla vgnslaavha garqvegamn gigeragncs
      241 leevimaikv rkdilnvhta inhqeiwrts qlvsqicnmp ipankaivgs gafahssgih
      301 qdgvlknren yeimtpesig lnqiqlnlts rsgraavkhr mdemgykese ynldnlydaf
      361 lkladkkgqv fdydlealaf igkqqeepeh frldyfsvqs gsndiataav klacgeevka
      421 eaangngpvd avyqainrit dynvelvkys ltakghgkda lgqvdivany ngrrfhgvgl
      481 atdivessak amvhvlnniw ratevekelq rkaqhnennk etv