MULTISPECIES: dihydroxy-acid dehydratase [Salmonella].

LOCUS       WP_000078502             571 aa            linear   BCT 23-JUL-2024
ACCESSION   WP_000078502
VERSION     WP_000078502.1
KEYWORDS    RefSeq.
SOURCE      Salmonella
  ORGANISM  Salmonella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 571)
  AUTHORS   Melse,O., Sutiono,S., Haslbeck,M., Schenk,G., Antes,I. and
            Sieber,V.
  TITLE     Structure-Guided Modulation of the Catalytic Properties of
            [2Fe-2S]-Dependent Dehydratases
  JOURNAL   Chembiochem 23 (10), e202200088 (2022)
   PUBMED   35263023
REFERENCE   2  (residues 1 to 571)
  AUTHORS   Singh,B.K. and Shaner,D.L.
  TITLE     Biosynthesis of Branched Chain Amino Acids: From Test Tube to Field
  JOURNAL   Plant Cell 7 (7), 935-944 (1995)
   PUBMED   12242394
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10469178
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..571
                     /organism="Salmonella"
                     /db_xref="taxon:590"
     gene            1..571
                     /gene="ilvD"
     Protein         1..571
                     /product="dihydroxy-acid dehydratase"
                     /EC_number="4.2.1.9"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0004160 - dihydroxy-acid dehydratase
                     activity [Evidence IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0009097 - isoleucine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009099 - valine biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=61882
     Region          33..568
                     /region_name="ILVD_EDD"
                     /note="Dehydratase family; pfam00920"
                     /db_xref="CDD:459998"
ORIGIN      
        1 msqkcqhard lwsqldalrl gmnyskedvn klqvlvddcy geshpgsfhl nqlgdeavlg
       61 vhesggravr hhvtdicdgw gqghdgmnyi lasreaianm veihasvvpy dagilisscd
      121 ksipahliaa arlnlpllhi pggsmrpapn mstsdlggit aklrkgeigi qqveamqqcg
      181 cptagacqfm gtastmqcms ealglalpgs allpstlaei rrvartaghq alylaeknit
      241 thkiltpaaf enaikvhaai ggstnamihl paiahelgwe lkpelfdrin neipyltniq
      301 psgeyvtemm wfaggvpmvq wylrdyldld vltvtgrtlg dnlemlhqsg fftrnhgyln
      361 nykvspeevi rkpenatkkg siavlkgnia pegavikyaa capdmhhhtg parvfnseed
      421 aqqaiihnhi epgdvifiry egakgsgape mlmttdaivy dkrldgkval itdgrfsgat
      481 sgpcvghvsp eaadggpial vedgdliemd vkgrklnivg idgmpkteee irrcleerra
      541 swkkpdysnr rgvfkqftan atslmagawl k