acetate--CoA ligase [Escherichia coli].

LOCUS       WP_000078217             652 aa            linear   BCT 03-JUN-2024
ACCESSION   WP_000078217
VERSION     WP_000078217.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR02188.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..652
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     gene            1..652
                     /gene="acs"
     Protein         1..652
                     /product="acetate--CoA ligase"
                     /EC_number="6.2.1.1"
                     /GO_function="GO:0003987 - acetate-CoA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016208 - AMP binding [Evidence IEA]"
                     /GO_process="GO:0019427 - acetyl-CoA biosynthetic process
                     from acetate [Evidence IEA]"
                     /calculated_mol_wt=71979
     Region          6..649
                     /region_name="PRK00174"
                     /note="acetyl-CoA synthetase; Provisional"
                     /db_xref="CDD:234677"
     Site            order(163..165,191,194,196,305,310..311,333..335,359..360,
                     363,386..389,411..416,500,512,515,523..526,584,589..590)
                     /site_type="active"
                     /db_xref="CDD:341270"
     Site            order(163..165,191,194,196,305,311,333..335,359..360,363,
                     523..525,584,589)
                     /site_type="other"
                     /note="CoA binding site [chemical binding]"
                     /db_xref="CDD:341270"
     Site            order(261,264..269,271..272)
                     /site_type="other"
                     /note="acyl-activating enzyme (AAE) consensus motif"
                     /db_xref="CDD:341270"
     Site            order(310..311,386..389,411..416,500,512,515,526)
                     /site_type="other"
                     /note="AMP binding site [chemical binding]"
                     /db_xref="CDD:341270"
     Site            order(310..311,386..387,414)
                     /site_type="other"
                     /note="acetate binding site [chemical binding]"
                     /db_xref="CDD:341270"
ORIGIN      
        1 msqihkhtip aniadrclin pqqyeamyqq sinapdtfwg eqgkildwik pyqkvkntsf
       61 apgnvsikwy edgtlnlaan cldrhlqeng drtaiiwegd dasqskhisy kelhrdvcrf
      121 antllklgik kgdvvaiymp mvpeaavaml acarigavhs vifggfspea vagriidsns
      181 rlvitsdegv ragrsiplkk nvddalknpn vtsvehvvvl krtggkidwq egrdlwwhdq
      241 veqasdqhqa eemnaedplf ilytsgstgk pkgvlhttgg ylvyaaltfk yvfdyhpgdi
      301 ywctadvgwv tghsyllygp lacgattlmf egvpnwptpa rmaqvvdkhq vnilytapta
      361 iralmaegdk aiegtdrssl rilgsvgepi npeawewywk kignekcpvv dtwwqtetgg
      421 fmitplpgat elkagsatrp ffgvqpalvd negnplegat egslvitdsw pgqartlfgd
      481 herfeqtyfs tfknmyfsgd garrdedsyy witgrvddvl nvsghrlgta eiesalvahp
      541 kiaeaavvgi phnikgqaiy ayvtlnhgee pspelyaevr nwvrkeigpl atpdvlhwtd
      601 slpktrsgki mrrilrkiaa gdtsnlgdts tladpgvvek lleekqaiam ps