MULTISPECIES: carnitine monooxygenase, oxygenase subunit YeaW

LOCUS       WP_000067822             374 aa            linear   BCT 17-JUL-2023
            [Enterobacteriaceae].
ACCESSION   WP_000067822
VERSION     WP_000067822.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 374)
  AUTHORS   Piskol,F., Neubauer,K., Eggers,M., Bode,L.M., Jasper,J.,
            Slusarenko,A., Reijerse,E., Lubitz,W., Jahn,D. and Moser,J.
  TITLE     Two-component carnitine monooxygenase from Escherichia coli:
            functional characterization, inhibition and mutagenesis of the
            molecular interface
  JOURNAL   Biosci Rep 42 (9) (2022)
   PUBMED   36066069
REFERENCE   2  (residues 1 to 374)
  AUTHORS   Kalnins,G., Sevostjanovs,E., Hartmane,D., Grinberga,S. and Tars,K.
  TITLE     CntA oxygenase substrate profile comparison and oxygen dependency
            of TMA production in Providencia rettgeri
  JOURNAL   J Basic Microbiol 58 (1), 52-59 (2018)
   PUBMED   29110324
REFERENCE   3  (residues 1 to 374)
  AUTHORS   Koeth,R.A., Levison,B.S., Culley,M.K., Buffa,J.A., Wang,Z.,
            Gregory,J.C., Org,E., Wu,Y., Li,L., Smith,J.D., Tang,W.H.W.,
            DiDonato,J.A., Lusis,A.J. and Hazen,S.L.
  TITLE     gamma-Butyrobetaine is a proatherogenic intermediate in gut
            microbial metabolism of L-carnitine to TMAO
  JOURNAL   Cell Metab 20 (5), 799-812 (2014)
   PUBMED   25440057
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR007839
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..374
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..374
                     /gene="yeaW"
     Protein         1..374
                     /product="carnitine monooxygenase, oxygenase subunit YeaW"
                     /EC_number="1.14.13.239"
                     /calculated_mol_wt=42430
     Region          21..370
                     /region_name="HcaE"
                     /note="Phenylpropionate dioxygenase or related
                     ring-hydroxylating dioxygenase, large terminal subunit
                     [Inorganic ion transport and metabolism, General function
                     prediction only]; COG4638"
                     /db_xref="CDD:443676"
     Region          188..371
                     /region_name="RHO_alpha_C_2"
                     /note="C-terminal catalytic domain of the oxygenase alpha
                     subunit of an uncharacterized subgroup of Rieske-type
                     non-heme iron aromatic ring-hydroxylating oxygenases;
                     cd08886"
                     /db_xref="CDD:176895"
     Site            order(196..197,201,204..205,208,210..211,215,291..292,
                     327..329,331..335,344..347,358,361,365)
                     /site_type="other"
                     /note="putative alpha subunit interface [polypeptide
                     binding]"
                     /db_xref="CDD:176895"
     Site            order(205..206,208..209,211..212,216,259..260,262,270,272,
                     281,283,313,316..317,321,325)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176895"
     Site            order(205..206,208..209,211..212,216,259..260,262,270,272,
                     281,283,313,316..317,321)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:176895"
     Site            order(211,216,325)
                     /site_type="other"
                     /note="Fe binding site [ion binding]"
                     /db_xref="CDD:176895"
ORIGIN      
        1 msnlspdfvl penfcanpqe awtiparfyt dqnafeheke nvfakswicv ahsselanan
       61 dyvtreiige sivlvrgrdk vlrafynvcp hrghqllsge gkaknvitcp yhawafkldg
      121 nlaharncen vanfdsdkaq lvpvrleeya gfvfinmdpn atsvedqlpg lgakvleacp
      181 evhdlklaar fttrtpanwk nivdnylecy hcgpahpgfs dsvqvdrywh tmhgnwtlqy
      241 gfakpseqsf kfeegtdaaf hgfwlwpctm lnvtpikgmm tviyefpvds ettlqnydiy
      301 ftneeltdeq ksliewyrdv frpedlrlve svqkglksrg yrgqgrimad ssgsgisehg
      361 iahfhnllaq vfkd