MULTISPECIES: bifunctional phosphopantothenoylcysteine

LOCUS       WP_000050139             406 aa            linear   BCT 17-JUN-2024
            decarboxylase/phosphopantothenate--cysteine ligase CoaBC
            [Enterobacteriaceae].
ACCESSION   WP_000050139
VERSION     WP_000050139.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 406)
  AUTHORS   Strauss,E., Kinsland,C., Ge,Y., McLafferty,F.W. and Begley,T.P.
  TITLE     Phosphopantothenoylcysteine synthetase from Escherichia coli.
            Identification and characterization of the last unidentified
            coenzyme A biosynthetic enzyme in bacteria
  JOURNAL   J Biol Chem 276 (17), 13513-13516 (2001)
   PUBMED   11278255
REFERENCE   2  (residues 1 to 406)
  AUTHORS   Spitzer,E.D., Jimenez-Billini,H.E. and Weiss,B.
  TITLE     beta-Alanine auxotrophy associated with dfp, a locus affecting DNA
            synthesis in Escherichia coli
  JOURNAL   J Bacteriol 170 (2), 872-876 (1988)
   PUBMED   3123465
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00521.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..406
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..406
                     /gene="coaBC"
     Protein         1..406
                     /product="bifunctional phosphopantothenoylcysteine
                     decarboxylase/phosphopantothenate--cysteine ligase CoaBC"
                     /EC_number="4.1.1.36"
                     /EC_number="6.3.2.5"
                     /GO_function="GO:0004632 - phosphopantothenate--cysteine
                     ligase activity [Evidence IEA]"
                     /GO_function="GO:0004633 - phosphopantothenoylcysteine
                     decarboxylase activity [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_process="GO:0015937 - coenzyme A biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0015941 - pantothenate catabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=43307
     Region          2..402
                     /region_name="CoaBC"
                     /note="Phosphopantothenoylcysteine
                     synthetase/decarboxylase CoaBC [Coenzyme transport and
                     metabolism]; COG0452"
                     /db_xref="CDD:440221"
ORIGIN      
        1 mslagkkivl gvsggiaayk tpelvrrlrd rgadvrvamt eaakafitpl slqavsgypv
       61 sdslldpaae aamghielgk wadlvilapa tadliarvaa gmandlvsti clatpapvav
      121 lpamnqqmyr aaatqhnlev lasrglliwg pdsgsqacgd igpgrmldpl tivdmavahf
      181 spvndlkhln imitagptre pldpvryisn hssgkmgfai aaaaarrgan vtlvsgpvsl
      241 ptppfvkrvd vmtalemeaa vnasvqqqni figcaavady raatvapeki kkqatqgdel
      301 tikmvknpdi vagvaalkdh rpyvvgfaae tnnveeyarq krirknldli candvsqptq
      361 gfnsdnnalh lfwqdgdkvl plerkellgq llldeivtry deknrr