MULTISPECIES: GDP-mannose 4,6-dehydratase [Enterobacteriaceae].

LOCUS       WP_000048190             373 aa            linear   BCT 01-JUL-2024
ACCESSION   WP_000048190
VERSION     WP_000048190.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 373)
  AUTHORS   Sullivan,F.X., Kumar,R., Kriz,R., Stahl,M., Xu,G.Y., Rouse,J.,
            Chang,X.J., Boodhoo,A., Potvin,B. and Cumming,D.A.
  TITLE     Molecular cloning of human GDP-mannose 4,6-dehydratase and
            reconstitution of GDP-fucose biosynthesis in vitro
  JOURNAL   J Biol Chem 273 (14), 8193-8202 (1998)
   PUBMED   9525924
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR01472.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..373
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..373
                     /gene="gmd"
     Protein         1..373
                     /product="GDP-mannose 4,6-dehydratase"
                     /EC_number="4.2.1.47"
                     /GO_function="GO:0008446 - GDP-mannose 4,6-dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0000271 - polysaccharide biosynthetic
                     process [Evidence IEA]"
                     /GO_process="GO:0019673 - GDP-mannose metabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=41916
     Region          3..355
                     /region_name="Gmd"
                     /note="GDP-D-mannose dehydratase [Cell
                     wall/membrane/envelope biogenesis]; COG1089"
                     /db_xref="CDD:440706"
ORIGIN      
        1 mskvalitgv tgqdgsylae fllekgyevh gikrrassfn tervdhiyqd phtcnpkfhl
       61 hygdlsdtsn ltrilrevqp devynlgams hvavsfespe ytadvdamgt lrlleairfl
      121 glekktrfyq astselyglv qeipqkettp fyprspyava klyaywitvn yresygmyac
      181 ngilfnhesp rrgetfvtrk itraianiaq glesclylgn mdslrdwgha kdyvkmqwmm
      241 lqqeqpedfv iatgvqysvr qfvemaaaql giklrfegtg veekgivvsv tghdapgvkp
      301 gdviiavdpr yfrpaevetl lgdptkahek lgwkpeitlr emvsemvand leaakkhsll
      361 kshgydvaia les