MULTISPECIES: phenylalanine--tRNA ligase subunit alpha

LOCUS       WP_000018588             327 aa            linear   BCT 23-MAY-2024
            [Enterobacteriaceae].
ACCESSION   WP_000018588
VERSION     WP_000018588.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 327)
  AUTHORS   Abibi,A., Ferguson,A.D., Fleming,P.R., Gao,N., Hajec,L.I., Hu,J.,
            Laganas,V.A., McKinney,D.C., McLeod,S.M., Prince,D.B., Shapiro,A.B.
            and Buurman,E.T.
  TITLE     The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA
            synthetase druggability
  JOURNAL   J Biol Chem 289 (31), 21651-21662 (2014)
   PUBMED   24936059
REFERENCE   2  (residues 1 to 327)
  AUTHORS   Mermershtain,I., Finarov,I., Klipcan,L., Kessler,N., Rozenberg,H.
            and Safro,M.G.
  TITLE     Idiosyncrasy and identity in the prokaryotic Phe-system: crystal
            structure of E. coli phenylalanyl-tRNA synthetase complexed with
            phenylalanine and AMP
  JOURNAL   Protein Sci 20 (1), 160-167 (2011)
   PUBMED   21082706
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00468.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..327
                     /gene="pheS"
     Protein         1..327
                     /product="phenylalanine--tRNA ligase subunit alpha"
                     /EC_number="6.1.1.20"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0004826 - phenylalanine-tRNA ligase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006432 - phenylalanyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /calculated_mol_wt=36671
     Region          1..327
                     /region_name="PheS"
                     /note="Phenylalanyl-tRNA synthetase alpha subunit
                     [Translation, ribosomal structure and biogenesis];
                     COG0016"
                     /db_xref="CDD:439787"
ORIGIN      
        1 mshlaelvas akaaisqasd vaaldnvrve ylgkkghltl qmttlrelpp eerpaagavi
       61 neakeqvqqa lnarkaeles aalnarlaae tidvslpgrr iengglhpvt rtidriesff
      121 gelgftvatg peieddyhnf dalnipghhp aradhdtfwf datrllrtqt sgvqirtmka
      181 qqppiriiap grvyrndydq thtpmfhqme glivdtnisf tnlkgtlhdf lrnffeedlq
      241 irfrpsyfpf tepsaevdvm gkngkwlevl gcgmvhpnvl rnvgidpevy sgfafgmgme
      301 rltmlrygvt dlrsffendl rflkqfk