MULTISPECIES: histidinol dehydrogenase [Salmonella].

LOCUS       WP_000009626             434 aa            linear   BCT 17-JUN-2024
ACCESSION   WP_000009626
VERSION     WP_000009626.1
KEYWORDS    RefSeq.
SOURCE      Salmonella
  ORGANISM  Salmonella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00069.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..434
                     /organism="Salmonella"
                     /db_xref="taxon:590"
     gene            1..434
                     /gene="hisD"
     Protein         1..434
                     /product="histidinol dehydrogenase"
                     /EC_number="1.1.1.23"
                     /GO_function="GO:0004399 - histidinol dehydrogenase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /GO_process="GO:0000105 - histidine biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=45758
     Region          5..427
                     /region_name="hisD"
                     /note="bifunctional histidinal dehydrogenase/ histidinol
                     dehydrogenase; Reviewed; PRK00877"
                     /db_xref="CDD:234853"
     Site            order(58,130,132..133,141,162,185..186,188,209..211,
                     213..214,262)
                     /site_type="other"
                     /note="NAD binding site [chemical binding]"
                     /db_xref="CDD:119329"
     Site            order(83..84,87..88,90,93..94,97..98,101..102,109,111,
                     115..119,122,124,136..140,204,219,223,250..251,254..255,
                     257..259,261..262,331,336,339..340,342..350,352,354..355,
                     357..361,363,365,375..376,378..382,384..385,388..395,
                     410..411,413..419)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:119329"
     Site            order(138,140,237,262,326..327,356,360..361,367,414,416,
                     419)
                     /site_type="active"
                     /note="product binding site [active]"
                     /db_xref="CDD:119329"
     Site            order(140,237,259,262,326..327,356,360..361,367,414,416,
                     419)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:119329"
     Site            order(259,262,360,419)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:119329"
     Site            326..327
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:119329"
ORIGIN      
        1 msfntlidwn scspeqqral ltrpaisasd sitrtvsdil dnvktrgdda lreysakfdk
       61 tevtalrvtp eeiaaagarl sdelkqamta avknietfhs aqtlppvdve tqpgvrcqqv
      121 trpvssvgly ipggsaplfs tvlmlatpar iagcqkvvlc spppiadeil yaaqlcgvqe
      181 ifnvggaqai aalafgsesv pkvdkifgpg nafvteakrq vsqrldgaai dmpagpsevl
      241 viadsgatpd fvasdllsqa ehgpdsqvil ltpdadiark vaeaverqla elpradtarq
      301 alsasrlivt kdlaqcvais nqygpehlii qtrnardlvd aitsagsvfl gdwspesagd
      361 yasgtnhvlp tygytatcss lgladfqkrm tvqelskagf salastietl aaaerltahk
      421 navtlrvnal keqa