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LOCUS NP_996333 2777 aa linear INV 26-DEC-2023 ACCESSION NP_996333 VERSION NP_996333.4 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 DBSOURCE REFSEQ: accession NM_206610.5 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (residues 1 to 2777) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (residues 1 to 2777) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (residues 1 to 2777) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (residues 1 to 2777) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (residues 1 to 2777) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (residues 1 to 2777) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (residues 1 to 2777) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (residues 1 to 2777) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (residues 1 to 2777) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (residues 1 to 2777) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (residues 1 to 2777) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (residues 1 to 2777) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (residues 1 to 2777) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (residues 1 to 2777) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (residues 1 to 2777) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (residues 1 to 2777) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (residues 1 to 2777) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (residues 1 to 2777) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (residues 1 to 2777) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (residues 1 to 2777) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (residues 1 to 2777) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (residues 1 to 2777) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (residues 1 to 2777) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. The reference sequence is identical to AAS65251. On Jan 16, 2013 this sequence version replaced NP_996333.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## Method: conceptual translation. FEATURES Location/Qualifiers source 1..2777 /organism="Drosophila melanogaster" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" Protein 1..2777 /product="Protostome-specific GEF, isoform E" /name="CG43947 gene product from transcript CG43947-RE" /note="CG43947-PE; PsGEF-PE; protostome-specific GEF" /calculated_mol_wt=297535 Region <99..209 /region_name="DUF4799" /note="Domain of unknown function (DUF4799); pfam16056" /db_xref="CDD:318308" Region 286..>381 /region_name="C2" /note="C2 domain; pfam00168" /db_xref="CDD:425499" Region 645..716 /region_name="PDZ_canonical" /note="canonical PDZ domain; cl49608" /db_xref="CDD:483948" Region 835..1007 /region_name="RhoGEF" /note="Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cl02571" /db_xref="CDD:470622" Region <2304..>2415 /region_name="PRK12323" /note="DNA polymerase III subunit gamma/tau; cl46901" /db_xref="CDD:481241" CDS 1..2777 /gene="PsGEF" /locus_tag="Dmel_CG43947" /old_locus_tag="Dmel_CG14045" /old_locus_tag="Dmel_CG14047" /gene_synonym="CG14045; CG14047; CG43947; Dmel\CG43947; DmPsGEF; EG:BACH48C10.4; EG:BACH7M4.1; EG:BACH7M4.2; FBgn0264598; null; psGEF; PsGef" /coded_by="NM_206610.5:260..8593" /db_xref="FLYBASE:FBpp0305709" /db_xref="GeneID:31224" /db_xref="FLYBASE:FBgn0264598" ORIGIN 1 mptmtrmhrh ssssavvees rgrrrgvgvp gvgdankenf gvhfmsspfg naslialqdl 61 snvhgkspqr rsfsegsgpr qatpqlaalr clprttggav aledsqlsss rmgdttldrm 121 ldaiiesark evrctktlpg agattsttil adnaewsets vhemevrtpt hlkrqrvvrr 181 knphktttin qtqshqakkl eplqlvpstk rclsfssssa ssdldedeqq vakrsslasp 241 tttppshctt ttssisssss snggadmeas qrgsidvsia fdakeqqlnv hvircrdlqr 301 shgsgngsin ayvkvalsgg aqppgygghs sggsmssgyq rtavhrhsgr pyfdqrfnfq 361 issgeetagq ylqlavwhrd rhlnsvpvtq sewqarvksg terrtaerla klenagneak 421 rseflgcstf plnelvhpds gvsagsyklh aqacppptsr hsqpkanagq dqkqeteaak 481 dqdkqqddsp aemaaavtvt pqkpvatgsg sgsnsaamal ndevisisid smgkedpllp 541 qqpqqpmkls kkalhqrdad enlflrflel dppadgnans tttqaqatgs qssaskanes 601 nanhlnngts ggrrqstmpn sggssvggav rqqqgrtpft mtkrltrtee rgfgfsivwt 661 hpprvekiea glsadrcgil pgdyvifvdk hnvvtmpead vlnlirsqgs sltleifrrs 721 gagattitst dlgqnnvhis trlgaavglg seehtlatta tgtttvmslq rttstriqpl 781 ansmsrpata csgttssiea akrrlhlpqv tfskesivpv tdnrrrfllq lisreqnfta 841 alhfgvdrfv qplgerkdli spndhrtlfq nidellriae dileqlcssd qqdqepqmnf 901 asrvylsktt aicaaykkyc ngikradcvl vnksrqtgse fiafitepav prkrpdltmf 961 ihrplqhfre ilklmqllag nchvdteehk nfstvinelq aayreitvss glmeplgegr 1021 plltlqdles rmvftkckpf tlavqgrqwi fggdlsrveg rsvkpywtll fsdiivfakv 1081 srdrvlfite epipianvvd scfhmrkktt efrltvdpng rlaesptgyc apdltrtpkr 1141 garrkslilr apslelkavw qnllqrqifl vnaalgstpl sspldspdvl ntlvplsdig 1201 lttasmgsmk lpsldsihlk qqqkqqrtnn shghvhsatg vatdrtadrs hghnhgihgg 1261 hveqiellid ekcrilnktg tpkssalhla nwmkgqldkq qqqarlaaia rsqenvsaed 1321 eqlifnsdse qderitywtr qqlekrtkel nlakenggls arpnfggkrl sgveelsmsa 1381 tsdiystsea egvtsvisqs hsttsdsqit vrsspivldk lavcrhchkn cqqsgpggar 1441 pgggggvnns sstpvllcns lkvqhsqssp nrccklsngi agatemanpk nsnrtgtgtg 1501 svtsmsssti tgelsskvva sssrretgdt esdvaqlitd eisqsqseat ddsvgampns 1561 srsagegnpv itgsrlrhld ppvsvsslpn ghcsagvggg spkplppprr trvvaqmcqe 1621 pprpkanqqv kaivtiteta rimrssptkg sgsgsatgtg svggspakya achcrctped 1681 fthaqlspdk mehqtcklle spkqttttle qkqedeqlsl mliglaqlap aatlcgqeri 1741 pkeenstpti avvpptpdsv ltktsthvwd nsgcssnggg tsttstattt tkqprqaiie 1801 nipedscdes pldeeppyrp mssalrrfgt mssleklpsd drmdeadeld ddldsfkpng 1861 hdgnspqnee ddedadsera lvqndlgass ssgvivngeg lasgawtnra gayvsdkmsf 1921 feesrafidk ylgrwnagda qqqhqqgtas etdeqmdect sgatsgeevw gtptsggdnd 1981 dqdlqlinse nthssptkss tslnddddte lmmdellmap pmtastirgl lprfyrrrle 2041 plfeeetesd eektqqdsdd ikkgeattng hyledsagss sdsesvppap plvprpvvpd 2101 reedpsaegq qenlamedqe dlhssverll pnlatsamgp rpllttrllp ttaidpqppa 2161 vlvassceyl ldqrpssvpg rdlaggsigt ttmtssrptp lspakaaatp igmnatmttk 2221 tttttmmtps rapsstisti ssasdttssg grasgrpprf vpppppprrl lltqtdliag 2281 qaktelprkk sgatadsgcs vavgdaasas dptaigsrtm pstpstssla savapkrpss 2341 tiietcllga prpasatssa tasrmakpir qspptqhqsq prgqscpaav papstaapda 2401 ptvpmphagc glsprlemrl alnhdilgde dlicyepgpd lttilghdls tfhrltgrdl 2461 lsrsatnrvq pkeavisysq qrnskmdtpt vnrrprplsa galggstsns npnnsrssss 2521 hgnsplgggl tragvepvgq qqlvvqaggg sagrvgggsg saggnstacs snrggsklgd 2581 leilarreki ysmsqsrsgc rvrettsttt lmamatemrs gmdsekrdss wpkraaaaas 2641 ltrtrsstsm dgagaisttt tttttmteea fletevgrsk rlinfikrrn seitasstss 2701 tpnfsdgaig eqpqpshsqs slllqklppg qsqaqdsvem aqmsprkdnd kpslnrrlwk 2761 qitkrrrtns vsqivag