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LOCUS NP_726773 2431 aa linear INV 26-DEC-2023 ACCESSION NP_726773 VERSION NP_726773.2 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 DBSOURCE REFSEQ: accession NM_166911.4 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (residues 1 to 2431) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (residues 1 to 2431) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (residues 1 to 2431) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (residues 1 to 2431) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (residues 1 to 2431) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (residues 1 to 2431) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (residues 1 to 2431) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (residues 1 to 2431) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (residues 1 to 2431) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (residues 1 to 2431) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (residues 1 to 2431) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (residues 1 to 2431) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (residues 1 to 2431) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (residues 1 to 2431) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (residues 1 to 2431) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (residues 1 to 2431) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (residues 1 to 2431) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (residues 1 to 2431) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (residues 1 to 2431) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (residues 1 to 2431) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (residues 1 to 2431) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (residues 1 to 2431) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (residues 1 to 2431) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. The reference sequence is identical to AAN09063. On Feb 27, 2003 this sequence version replaced NP_726773.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## Method: conceptual translation. FEATURES Location/Qualifiers source 1..2431 /organism="Drosophila melanogaster" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" Protein 1..2431 /product="trithorax-related, isoform D" /EC_number="2.1.1.364" /EC_number="2.1.1.370" /name="CG3848 gene product from transcript CG3848-RD" /note="CG3848-PD; trr-PD; trithorax related; Trithorax-related; Trx-related; trithorax-related protein" /calculated_mol_wt=259698 Region 184..>320 /region_name="PHA03255" /note="BDLF3; Provisional" /db_xref="CDD:165513" Region <623..>851 /region_name="PRK13914" /note="invasion associated endopeptidase" /db_xref="CDD:237555" Region 1898..2002 /region_name="ePHD2_KMT2C_like" /note="Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D); cd15666" /db_xref="CDD:277136" Site order(1957,1966..1970,1976,1997) /site_type="other" /note="putative histone H3 binding site [polypeptide binding]" /db_xref="CDD:277136" Region 2067..2118 /region_name="FYRN" /note="F/Y-rich N-terminus; pfam05964" /db_xref="CDD:461787" Region 2126..2215 /region_name="FYRC" /note="FY-rich domain, C-terminal region; smart00542" /db_xref="CDD:197781" Region 2278..2430 /region_name="SET_KMT2C_2D" /note="SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; cd19171" /db_xref="CDD:380948" Site order(2279..2281,2283..2284,2286,2314,2319..2320, 2322..2326,2328..2329,2331..2334,2344,2346..2348,2354, 2357..2359,2361..2363,2365,2377,2379,2382,2395,2404, 2406..2408) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:380948" Site order(2300..2303,2320,2331,2334,2344..2348,2354, 2365..2369,2377,2379,2404,2406..2408,2418..2421,2430) /site_type="active" /db_xref="CDD:380948" Site order(2300..2303,2344..2345,2365..2369,2406,2418..2421, 2430) /site_type="other" /note="SAM binding site" /db_xref="CDD:380948" Site order(2320,2331,2334,2344,2346..2348,2354,2365,2377,2379, 2404,2406..2408) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:380948" Site order(2371,2419,2421,2426) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:380948" CDS 1..2431 /gene="trr" /locus_tag="Dmel_CG3848" /gene_synonym="anon-2Bb; CG3848; Dmel\CG3848; dmll3/4; EG:63B12.3; Trr; TRR" /coded_by="NM_166911.4:176..7471" /db_xref="FLYBASE:FBpp0070347" /db_xref="GeneID:31149" /db_xref="FLYBASE:FBgn0023518" ORIGIN 1 mnipkvttsl gaaekakper vasvaaaafn avslqkrsgd dtatpaedpt rkkaktelll 61 gtgtaapslp akasstapqq llyqrsgqqa kaqvkaasep qdvetadgvw dardqqiivc 121 nfgsgtemga ikaedadkqs eyristprns qsnpllhrnt aftsftkkeg asssasssss 181 tasvisieps gsgqdhaens gksedldyvl mpasgadsst svgnstgtgt pagtpigatt 241 stiilnanng tagvsgagtt tiltqksght nynifnttat gsqtptttll nrvnlhpkmk 301 tqlmvnakkl sevtqttakv signktisvp llkplmsasg aataggativ eskqllqpgg 361 qvttvmsaaq qsggqqvhph vhshahhnft klikrgpkns gtivsfsglq ikpantkiva 421 tkvvskkmlq lqqhqqqiqq qqqlqqlqvt sggglapptg sivtitttnp sqtyamvqds 481 atvgpaahse ddapaprkit aysenlqkil nksksqestg gpeeftnins vvikpldknt 541 lncppsfnif kqqqhsqaaq sqsisavgsg agtpvtftma sgnasdlatt stvsvsagti 601 cinspmmgtr piisiqnkni slvlskttma qqkpkmittt tlssqaalqm hhaliqdssa 661 dkagssansg satsgasmql klttantptk lsvslapdvv kleevgsesk akllvkqeav 721 vkdstgtpts eeraeeigtp ekrlnanatm tainqvqnqs anqiqmatst stasnpstpn 781 ptvnatpmnn qrsaaednal lkqllqnnss shslnqisit sahvgsasas aplsarkvin 841 vrapsmgkvr sledqlarpv ippvptatqa agsssssgsv atstttttva sggssqqvat 901 asatalpvsa vaittpgvgg eakleqksdq paaimqnqsq nqappppppp qqqqqqqlhq 961 pqqlqpsphq vkqtvqivsk etsfisgpva aktlvteats kpaellpppp yematapisn 1021 vtisistkqa apkelqmkpk avamslpmeq gdeslpeqae pplhseqgat aagvaphsgg 1081 plvsaqwtnn hleggvattk ipfkpgepqk rklpmhpqld ekqiqqqaei pistslpttp 1141 tgqgtpdkvq lisaiatyvk ksgvpneaqp iqnqsqgqvq mqaqmqatmq ghlsgqmsgq 1201 isghaagqip aqmhlqvqhq lhmavhpqqq qqqlhqnqpq natiplpvtg qgavpipvpt 1261 meskagdqrk rrkrevqkpr rtnlnagqag galkdltgpl pagamvqlag mppgtqyiqg 1321 aasgtghvit stgqgvtlgg vgastgasss pmlkkrvrkf skveedhdaf tekllthirq 1381 mqplqvleph lnrnfhflig snetsgggsp asmssaasag sssagggklk ggsrgwplsr 1441 hlegledcdg tvlgrygrvn lpgipslyds erfggsrglv ggsartrsps paespgaekm 1501 lpmssiqndf ydqefsthme rnprerlvrh igavkdcnle tvdlvesegv aawatlprlt 1561 rypglillng nsrchgrmsp valpedpltm rfpvspllrs cgeelrktqq melgmgplgn 1621 nnnnnyqqkn qnvilalpas aseniagvlr dlanllhlap altckiiedk ignkledqfm 1681 nqddekhvdf krplsqvshg hlrkilngrr klcrscgnvv hatglrvprh svpaleeqlp 1741 rlaqlmdmlp rksvpppfvy fcdracfarf kwngkdgqae aaslllqpag gsavkssngd 1801 spgsfcasst apaemvvkqe pededektps vpgnptnipa qrkcivkcfs adcfttdsap 1861 sgleldgtag agtgagpvnn tvwetetsgl qledtrqcvf cnqrgdgqad gpsrllnfdv 1921 dkwvhlncal wsngvyetvs galmnfqtal qaglsqacsa chqpgatikc fksrcnslyh 1981 lpcaireecv fyknksvhcs vhghahagit mgagagattg aglggsvadn elsslvvhrr 2041 vfvdrdenrq vatvmhysel snllrvgnmt flnvgqllph qleafhtphy iypigykvsr 2101 yywcvrrpnr rcryicsiae agckpefriq vqdagdkepe refrgsspsa vwqqilqpit 2161 rlrkvhkwlq lfpqhisged lfgltepaiv rileslpgie tltdyrfkyg rnpllefpla 2221 inpsgaarte pkqrqllvwr kphtqrtags cstqrmansa aiagevacpy skqfvhskss 2281 qykkmkqewr nnvylarski qglglyaard iekhtmiiey igevirtevs eirekqyesk 2341 nrgiymfrld edrvvdatls gglaryinhs cnpncvteiv evdrdvriii fakrkiyrge 2401 elsydykfdi edeshkipca cgapncrkwm n