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LOCUS NP_572888 2362 aa linear INV 26-DEC-2023 ACCESSION NP_572888 VERSION NP_572888.2 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 DBSOURCE REFSEQ: accession NM_132660.4 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (residues 1 to 2362) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (residues 1 to 2362) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (residues 1 to 2362) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (residues 1 to 2362) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (residues 1 to 2362) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (residues 1 to 2362) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (residues 1 to 2362) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (residues 1 to 2362) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (residues 1 to 2362) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (residues 1 to 2362) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (residues 1 to 2362) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (residues 1 to 2362) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (residues 1 to 2362) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (residues 1 to 2362) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (residues 1 to 2362) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (residues 1 to 2362) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (residues 1 to 2362) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (residues 1 to 2362) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (residues 1 to 2362) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (residues 1 to 2362) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (residues 1 to 2362) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (residues 1 to 2362) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (residues 1 to 2362) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. The reference sequence is identical to AAF48273. On Nov 6, 2002 this sequence version replaced NP_572888.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## Method: conceptual translation. FEATURES Location/Qualifiers source 1..2362 /organism="Drosophila melanogaster" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" Protein 1..2362 /product="SET domain containing 2, isoform A" /EC_number="2.1.1.370" /name="CG1716 gene product from transcript CG1716-RA" /note="CG1716-PA; Set2-PA; drosophila hypb" /calculated_mol_wt=262153 Region <709..832 /region_name="valS" /note="valyl-tRNA synthetase; Provisional; PRK14900" /db_xref="CDD:237855" Region 1358..1410 /region_name="AWS" /note="associated with SET domains; smart00570" /db_xref="CDD:197795" Region 1410..1551 /region_name="SET_SETD2" /note="SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; cd19172" /db_xref="CDD:380949" Site order(1421..1423,1440,1450,1454,1458,1463..1469, 1486..1490,1497..1499,1514,1525..1529,1531..1535, 1537..1541,1550) /site_type="active" /db_xref="CDD:380949" Site order(1421..1423,1463..1466,1486..1490,1527,1537..1541, 1550) /site_type="other" /note="SAM binding site" /db_xref="CDD:380949" Site order(1440,1450,1454,1465..1469,1497..1499,1514, 1525..1529) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:380949" Site order(1492,1539,1541,1546) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:380949" Region 2014..2043 /region_name="WW" /note="WW domain; pfam00397" /db_xref="CDD:459800" Region 2266..2355 /region_name="SRI" /note="SRI (Set2 Rpb1 interacting) domain; pfam08236" /db_xref="CDD:462404" CDS 1..2362 /gene="Set2" /locus_tag="Dmel_CG1716" /gene_synonym="CG1716; dHypb; Dmel\CG1716; dSet2; Hypb; SET-2; set2; SET2" /coded_by="NM_132660.4:226..7314" /db_xref="FLYBASE:FBpp0073610" /db_xref="GeneID:32301" /db_xref="FLYBASE:FBgn0030486" ORIGIN 1 meesgppsnp spvasrgrgr grppkvalsa lgntpphinp slkhadaeas ptapedqdsg 61 qsecrrssrk kiikfdvrdl lnknrkahki qiearidsnp stghsqsgtt aastsmstat 121 asaasassaa tvsrlfsmfe mshqslpppp ppptaleifa kprptqsliv aqvtsepsav 181 ggahpvqtma glppvtprkr grprksqlad aaiiptvivp scsdsdtnst stttsnmssd 241 sgelpgfpiq kpksklrvsl krlklggrle ssdsgnspss sspeveppal qdenamderp 301 kqeqnlsrmv daeensdsds qiifieiete spkgeeeqee grpvevepqd lididmelak 361 qeptpdpeed ldeimvevls gppslwsadd eaeeeedatv qratppgkep aadscssapr 421 rsrrsaplsg ssrqgktlee tfaeiaaess kqileaeesq dqeeqhilid liedtlsese 481 vtssvsptie hmvveevvve enqlvdeade ildskqefvi kkvfsesdni aaslnkdife 541 pkvetkatcg evvprpemvt edvyitegia atleksavvt kpttemiaet klsdevviep 601 plkdesdpkq tevelpeskp avnipkseri lsaevettss plvppecctl esvsgpvlle 661 tslsteeksn envettplkt eaakedsppa apeeeasnss eepnflledy esnqeqvaed 721 emmkcnnqkg qkqtplpemk epekpvaetv skkekamenp arsspaivdk kvragemekk 781 vvkstkgtvp ekkmdskksc aavtpakqke sgksakeail kketekekss akldssspnt 841 ldkkgkdtaq wspqlqtlpk sstkppqesa psviskttsn qpapkeeqha akkglsdnsp 901 psvlkakeka vsgfvecdam fkamdlanaq lrldeknkkk lkkvptkvea ppkvepptav 961 pvpgqkksls gktslrrntv yedspnlern sspssdsaqa ntsagklkps kvkkkinprr 1021 sticeaakdl rsssssstpt revaasspvs tssdssskrn gskrttsdld ggskldqrry 1081 ticedrqpet aipvpltkrr fsmhpkasan plhdtllqta gkkrgrkegk eslsrqnsld 1141 ssssasqgap kkkalksaei lsaalletes sestssgskm srwdvqtspe leaanpfgdi 1201 akfiedgvnl lkrdkvdedq rkegqdevkr eadpeedefa qrvanmetpa ttptpsptqs 1261 npedsasttt vlkeletggg vrrshrikqk pqgprasqgr gvasvalapi smdeqlaela 1321 nieaineqfl rseglntfql lkenfyrcar qvsqenaemq cdcfltgdee aqghlscgag 1381 cinrmlmiec gplcsngarc tnkrfqqhqc wpcrvfrtek kgcgitaell ippgefimey 1441 vgevidseef errqhlyskd rnrhyyfmal rgeavidats kgnisryinh scdpnaetqk 1501 wtvngelrig ffsvkpiqpg eeitfdyqyl rygrdaqrcy ceaancrgwi ggepdsdege 1561 qldeesdsda emdeeeleae peegqprksa kakaksklka klplatgrkr keqtkpkdre 1621 ykagrwlkps atgssssaek ppkkpkvnkf qamledpdvv eelsllrrgg lknqqdtlrf 1681 srclvrakll ktrlallrvl thgelpcrrl fldyhglrll hawisengnd dqlrealldt 1741 leslpipnrt mlsdsrvyqs vqlwsnsleq qlavvpqekq aalhkrmval lqkwqalpei 1801 fripkrerie qmkeheread rqqkhvhast aledqreres sndrfrqdrf rrdttssrig 1861 kpirmsgnnt ictittqqkg sngapdgmtr ndnrrrsdig ppseqrrtls kelrrslfer 1921 kvaldeaerr vctedrlehe lrceffgadi ntdpkqlpfy qktdtnewfn sddvpvpapp 1981 rtelltkall spdidvgqga tdveyklppg vdplppawnw qvtsdgdiyy ynlrerisqw 2041 eppspeqrlq tlleenttqq plhelqidpa vleneliqvd tdyvgslsak slaqyieakv 2101 rerrdlrrsk lvsirlispr rdedrlynql esrkykenke kirrrkelyr rrkievlpda 2161 vdeipvpgka lpiqpylfss deeetkvaai eqpaaeeeqd slnmapstsh aamaalgkav 2221 aqptglgtvg krklpmppsv tvkkhrqeqr skkvkssqsp ltatsareah ekfrfeisgh 2281 vanflrpyrk esctlgrits dedykflvnr lsyhittkem rycevsgnpl sctesvkhks 2341 ydfinqymrq kgpvykkpae nd