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LOCUS NP_525040 2410 aa linear INV 26-DEC-2023 ACCESSION NP_525040 VERSION NP_525040.2 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 DBSOURCE REFSEQ: accession NM_080301.3 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (residues 1 to 2410) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (residues 1 to 2410) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (residues 1 to 2410) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (residues 1 to 2410) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (residues 1 to 2410) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (residues 1 to 2410) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (residues 1 to 2410) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (residues 1 to 2410) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (residues 1 to 2410) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (residues 1 to 2410) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (residues 1 to 2410) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (residues 1 to 2410) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (residues 1 to 2410) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (residues 1 to 2410) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (residues 1 to 2410) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (residues 1 to 2410) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (residues 1 to 2410) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (residues 1 to 2410) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (residues 1 to 2410) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (residues 1 to 2410) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (residues 1 to 2410) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (residues 1 to 2410) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (residues 1 to 2410) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. The reference sequence is identical to AAF45684. On Nov 6, 2002 this sequence version replaced NP_525040.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## Method: conceptual translation. FEATURES Location/Qualifiers source 1..2410 /organism="Drosophila melanogaster" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" Protein 1..2410 /product="trithorax-related, isoform C" /EC_number="2.1.1.364" /EC_number="2.1.1.370" /name="CG3848 gene product from transcript CG3848-RC" /note="CG3848-PC; trr-PC; trithorax related; Trithorax-related; Trx-related; trithorax-related protein" /calculated_mol_wt=257276 Region 124..>299 /region_name="PHA03255" /note="BDLF3; Provisional" /db_xref="CDD:165513" Region <602..>830 /region_name="PRK13914" /note="invasion associated endopeptidase" /db_xref="CDD:237555" Region 1877..1981 /region_name="ePHD2_KMT2C_like" /note="Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D); cd15666" /db_xref="CDD:277136" Site order(1936,1945..1949,1955,1976) /site_type="other" /note="putative histone H3 binding site [polypeptide binding]" /db_xref="CDD:277136" Region 2046..2097 /region_name="FYRN" /note="F/Y-rich N-terminus; pfam05964" /db_xref="CDD:461787" Region 2105..2194 /region_name="FYRC" /note="FY-rich domain, C-terminal region; smart00542" /db_xref="CDD:197781" Region 2257..2409 /region_name="SET_KMT2C_2D" /note="SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; cd19171" /db_xref="CDD:380948" Site order(2258..2260,2262..2263,2265,2293,2298..2299, 2301..2305,2307..2308,2310..2313,2323,2325..2327,2333, 2336..2338,2340..2342,2344,2356,2358,2361,2374,2383, 2385..2387) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:380948" Site order(2279..2282,2299,2310,2313,2323..2327,2333, 2344..2348,2356,2358,2383,2385..2387,2397..2400,2409) /site_type="active" /db_xref="CDD:380948" Site order(2279..2282,2323..2324,2344..2348,2385,2397..2400, 2409) /site_type="other" /note="SAM binding site" /db_xref="CDD:380948" Site order(2299,2310,2313,2323,2325..2327,2333,2344,2356,2358, 2383,2385..2387) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:380948" Site order(2350,2398,2400,2405) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:380948" CDS 1..2410 /gene="trr" /locus_tag="Dmel_CG3848" /gene_synonym="anon-2Bb; CG3848; Dmel\CG3848; dmll3/4; EG:63B12.3; Trr; TRR" /coded_by="NM_080301.3:176..7408" /db_xref="FLYBASE:FBpp0070346" /db_xref="GeneID:31149" /db_xref="FLYBASE:FBgn0023518" ORIGIN 1 mnipkvttsl gaaekakper vasvaaaafn avslqkrsgd dtatpaedpt rkkaktelll 61 gtgtaapslp akasstapqq llyqrsgqqa kaqvkaasep qdvetadgvw dardqqiivc 121 nfgsgtemga ikaedadkqt ftsftkkega sssassssst asvisiepsg sgqdhaensg 181 ksedldyvlm pasgadssts vgnstgtgtp agtpigatts tiilnanngt agvsgagttt 241 iltqksghtn ynifnttatg sqtptttlln rvnlhpkmkt qlmvnakkls evtqttakvs 301 ignktisvpl lkplmsasga ataggative skqllqpggq vttvmsaaqq sggqqvhphv 361 hshahhnftk likrgpknsg tivsfsglqi kpantkivat kvvskkmlql qqhqqqiqqq 421 qqlqqlqvts ggglapptgs ivtitttnps qtyamvqdsa tvgpaahsed dapaprkita 481 ysenlqkiln ksksqestgg peeftninsv vikpldkntl ncppsfnifk qqqhsqaaqs 541 qsisavgsga gtpvtftmas gnasdlatts tvsvsagtic inspmmgtrp iisiqnknis 601 lvlskttmaq qkpkmitttt lssqaalqmh haliqdssad kagssansgs atsgasmqlk 661 lttantptkl svslapdvvk leevgseska kllvkqeavv kdstgtptse eraeeigtpe 721 krlnanatmt ainqvqnqsa nqiqmatsts tasnpstpnp tvnatpmnnq rsaaednall 781 kqllqnnsss hslnqisits ahvgsasasa plsarkvinv rapsmgkvrs ledqlarpvi 841 ppvptatqaa gsssssgsva tstttttvas ggssqqvata satalpvsav aittpgvgge 901 akleqksdqp aaimqnqsqn qapppppppq qqqqqqlhqp qqlqpsphqv kqtvqivske 961 tsfisgpvaa ktlvteatsk paellppppy ematapisnv tisistkqaa pkelqmkpka 1021 vamslpmeqg deslpeqaep plhseqgata agvaphsggp lvsaqwtnnh leggvattki 1081 pfkpgepqkr klpmhpqlde kqiqqqaeip istslpttpt gqgtpdkvql isaiatyvkk 1141 sgvpneaqpi qnqsqgqvqm qaqmqatmqg hlsgqmsgqi sghaagqipa qmhlqvqhql 1201 hmavhpqqqq qqlhqnqpqn atiplpvtgq gavpipvptm eskagdqrkr rkrevqkprr 1261 tnlnagqagg alkdltgplp agamvqlagm ppgtqyiqga asgtghvits tgqgvtlggv 1321 gastgasssp mlkkrvrkfs kveedhdaft ekllthirqm qplqvlephl nrnfhfligs 1381 netsgggspa smssaasags ssagggklkg gsrgwplsrh legledcdgt vlgrygrvnl 1441 pgipslydse rfggsrglvg gsartrspsp aespgaekml pmssiqndfy dqefsthmer 1501 nprerlvrhi gavkdcnlet vdlvesegva awatlprltr ypglillngn srchgrmspv 1561 alpedpltmr fpvspllrsc geelrktqqm elgmgplgnn nnnnyqqknq nvilalpasa 1621 seniagvlrd lanllhlapa ltckiiedki gnkledqfmn qddekhvdfk rplsqvshgh 1681 lrkilngrrk lcrscgnvvh atglrvprhs vpaleeqlpr laqlmdmlpr ksvpppfvyf 1741 cdracfarfk wngkdgqaea aslllqpagg savkssngds pgsfcassta paemvvkqep 1801 ededektpsv pgnptnipaq rkcivkcfsa dcfttdsaps gleldgtaga gtgagpvnnt 1861 vwetetsglq ledtrqcvfc nqrgdgqadg psrllnfdvd kwvhlncalw sngvyetvsg 1921 almnfqtalq aglsqacsac hqpgatikcf ksrcnslyhl pcaireecvf yknksvhcsv 1981 hghahagitm gagagattga glggsvadne lsslvvhrrv fvdrdenrqv atvmhysels 2041 nllrvgnmtf lnvgqllphq leafhtphyi ypigykvsry ywcvrrpnrr cryicsiaea 2101 gckpefriqv qdagdkeper efrgsspsav wqqilqpitr lrkvhkwlql fpqhisgedl 2161 fgltepaivr ileslpgiet ltdyrfkygr npllefplai npsgaartep kqrqllvwrk 2221 phtqrtagsc stqrmansaa iagevacpys kqfvhskssq ykkmkqewrn nvylarskiq 2281 glglyaardi ekhtmiieyi gevirtevse irekqyeskn rgiymfrlde drvvdatlsg 2341 glaryinhsc npncvteive vdrdvriiif akrkiyrgee lsydykfdie deshkipcac 2401 gapncrkwmn