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LOCUS NP_511114 2554 aa linear INV 26-DEC-2023 ACCESSION NP_511114 VERSION NP_511114.2 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 DBSOURCE REFSEQ: accession NM_078559.3 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (residues 1 to 2554) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (residues 1 to 2554) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (residues 1 to 2554) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (residues 1 to 2554) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (residues 1 to 2554) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (residues 1 to 2554) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (residues 1 to 2554) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (residues 1 to 2554) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (residues 1 to 2554) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (residues 1 to 2554) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (residues 1 to 2554) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (residues 1 to 2554) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (residues 1 to 2554) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (residues 1 to 2554) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (residues 1 to 2554) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (residues 1 to 2554) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (residues 1 to 2554) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (residues 1 to 2554) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (residues 1 to 2554) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (residues 1 to 2554) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (residues 1 to 2554) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (residues 1 to 2554) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (residues 1 to 2554) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. The reference sequence is identical to AAF47992. On Nov 6, 2002 this sequence version replaced NP_511114.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## Method: conceptual translation. FEATURES Location/Qualifiers source 1..2554 /organism="Drosophila melanogaster" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" Protein 1..2554 /product="sevenless" /EC_number="2.7.10.1" /name="CG18085 gene product from transcript CG18085-RA" /note="CG18085-PA; sev-PA" /calculated_mol_wt=287025 Region 439..520 /region_name="fn3" /note="Fibronectin type III domain; pfam00041" /db_xref="CDD:394996" Region 826..921 /region_name="FN3" /note="Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063" /db_xref="CDD:238020" Site order(909,911,913..914) /site_type="active" /note="Cytokine receptor motif [active]" /db_xref="CDD:238020" Region 992..>1118 /region_name="Vgb" /note="Streptogramin lyase [Defense mechanisms]; COG4257" /db_xref="CDD:443399" Region 993..1026 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 1292..1374 /region_name="FN3" /note="Fibronectin type 3 domain; smart00060" /db_xref="CDD:214495" Site order(1799,1871,1886) /site_type="active" /note="Interdomain contacts [active]" /db_xref="CDD:238020" Region 1800..1891 /region_name="fn3" /note="Fibronectin type III domain; pfam00041" /db_xref="CDD:394996" Site order(1887..1888,1890..1891) /site_type="active" /note="Cytokine receptor motif [active]" /db_xref="CDD:238020" Region 1993..2111 /region_name="FN3" /note="Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; cd00063" /db_xref="CDD:238020" Site order(1993,2086,2102) /site_type="active" /note="Interdomain contacts [active]" /db_xref="CDD:238020" Site order(2103..2104,2106..2107) /site_type="active" /note="Cytokine receptor motif [active]" /db_xref="CDD:238020" Region 2213..2483 /region_name="PTKc_c-ros" /note="Catalytic domain of the Protein Tyrosine Kinase, C-ros; cd05044" /db_xref="CDD:270640" Site order(2215..2219,2223,2240,2242,2286..2289,2292..2293, 2343,2347..2348,2350,2368,2386..2390,2399,2433) /site_type="active" /db_xref="CDD:270640" Site order(2215..2216,2218..2219,2223,2240,2242,2286..2289, 2292..2293,2347..2348,2350,2368) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270640" Site order(2343,2347,2386..2390,2399,2433) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270640" Site 2367..2392 /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270640" CDS 1..2554 /gene="sev" /locus_tag="Dmel_CG18085" /gene_synonym="7LES; 7less; CG18085; CT3980; Dmel\CG18085; DmHD-265; DROSEV; DROSEV1; HD-265; Sev; SEV; sev(AC)[[14]]" /coded_by="NM_078559.3:227..7891" /db_xref="FLYBASE:FBpp0073249" /db_xref="GeneID:32039" /db_xref="FLYBASE:FBgn0003366" ORIGIN 1 mtmfwqqnvd hqsdeqdkqa kgaaptkrln isfnvkiavn vntkmttthi nqqapgtsss 61 ssnsqnasps kivvrqqsss fdlrqqlarl grqlasgqdg hggistilii nllllillsi 121 ccdvcrshny tvhqspepvs kdqmrllrpk ldsdvvekva iwhkhaaaap psivegiais 181 srpqstmahh pddrdrdrdp seeqhgvder mvlervtrdc vqrciveedl fldefgiqce 241 kadngekcyk trctkgcaqw yralkelesc qeaclslqfy pydmpcigac emaqrdywhl 301 qrlaishlve rtqpqlerap radgqstplt irwamhfpeh ylasrpfniq yqfvdhhgee 361 ldleqedqda sgetgssawf nladydcdey yvceileali pytqyrfrfe lpfgenrdev 421 lyspatpayq tppegapisa pviehlmgld dshlavhwhp grftngpieg yrlrlssseg 481 natseqlvpa grgsyifsql qagtnytlal sminkqgegp vakgfvqths arnekpakdl 541 tesvllvgrr avmwqslepa gensmiyqsq eeladiawsk reqqlwllnv hgelrslkfe 601 sgqmvspaqq lkldlgniss grwvprrlsf dwlhhrlyfa mespernqss fqiistdllg 661 estqkvgesf dlpveqlevd alngwifwrn eeslwrqdlh grmihrllri rqpgwflvqp 721 qhfiihlmlp qegkfleisy dggfkhplpl pppsngagng passhwqsfa llgrslllpd 781 sgqlilveqq gqaaspsasw plknlpdcwa villvpesqp ltsaggkphs lkallgaqaa 841 kiswkepern pyqsadaars wsyelevldv asqsafsirn irgpifglqr lqpdnlyqlr 901 vrainvdgep gewteplaar twplgphrlr wasrqgsvih tnelgeglev qqeqlerlpg 961 pmtmvnesvg yyvtgdgllh cinlvhsqwg cpiseplqhv gsvtydwrgg rvywtdlarn 1021 cvvrmdpwsg srellpvfea nflaldprqg hlyyatssql srhgstpdea vtyyrvngle 1081 gsiasfvldt qqdqlfwlvk gsgalrlyra pltaggdslq miqqikgvfq avpdslqllr 1141 plgallwler sgrrarlvrl aapldvmelp tpdqaspasa lqlldpqplp prdegvipmt 1201 vlpdsvrldd ghwddfhvrw qpstsggnhs vsyrlllefg qrlqtldlst pfarltqlpq 1261 aqlqlkisit prtawrsgdt trvqlttppv apsqprrlrv fverlatalq eanvsavlrw 1321 dapeqgqeap mqaleyhisc wvgselheel rlnqsalear vehlqpdqty hfqvearvaa 1381 tgaaagaash alhvapevqa vprvlyanae figeldldtr nrrrlvhtas pvehlvgieg 1441 eqrllwvneh vellthvpgs apaklarmra evlalavdwi qrivywaeld atapqaaiiy 1501 rldlcnfegk ilqgervwst prgrllkdlv alpqaqsliw leyeqgsprn gslrgrnltd 1561 gselewatvq plirlhagsl epgsetlnlv dnqgklcvyd varqlctasa lraqlnllge 1621 dsiagqlaqd sgylyavknw siraygrrrq qleytvelep eevrllqahn yqayppkncl 1681 llpssggsll katdceeqrc llhlpmitas edcplpipgv ryqlnltlak epgseehdhg 1741 meplgqwllg ageslnltdl lpftryrvsg ilssfyqkkl alptlvlapl elltasatps 1801 pprnfsvrvl sprelevswl ppeqlrsesv yytlhwqqel dgenvqdrre weaherrlet 1861 agthrltgik pgsgyslwvq ahatptksns serlhvrsfa elpelqllel gpyslsltwa 1921 gtpdplgslq lecrssaeql rrnvagnhtk mvveplqprt ryqcrlllgy aatpgaplyh 1981 gtaevyetlg dapsqpgkpq lehiaeevfr vtwtaargng apialynlea lqarsdirrr 2041 rrrrrrnsgg sleqlpwaee pvvvedqwld fcnttelsci vkslhssrll lfrvrarsle 2101 hgwgpysees ervaepfvsp ekrgslvlai iapaaivssc vlalvlvrkv qkrrlrakkl 2161 lqqsrpsiws nlstlqtqqq lmavrnrafs ttlsdadial lpqinwsqlk llrflgsgaf 2221 gevyegqlkt edseepqrva ikslrkgase faellqeaql msnfkheniv clvgicfdte 2281 sislimehme agdllsylra aratstqepq ptaglslsel lamcidvang csyledmhfv 2341 hrdlacrncl vtestgstdr rrtvkigdfg lardiyksdy yrkegegllp vrwmspeslv 2401 dglfttqsdv wafgvlcwei ltlgqqpyaa rnnfevlahv keggrlqqpp mcteklysll 2461 llcwrtdpwe rpsfrrcynt lhaistdlrr tqmasatadt vvscsrpefk vrfdgqplee 2521 hrehnerped enltlrevpl kdkqlyaneg vsrl