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LOCUS NP_476859 2703 aa linear INV 26-DEC-2023 ACCESSION NP_476859 VERSION NP_476859.2 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 DBSOURCE REFSEQ: accession NM_057511.4 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (residues 1 to 2703) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (residues 1 to 2703) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (residues 1 to 2703) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (residues 1 to 2703) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (residues 1 to 2703) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (residues 1 to 2703) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (residues 1 to 2703) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (residues 1 to 2703) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (residues 1 to 2703) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (residues 1 to 2703) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (residues 1 to 2703) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (residues 1 to 2703) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (residues 1 to 2703) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (residues 1 to 2703) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (residues 1 to 2703) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (residues 1 to 2703) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (residues 1 to 2703) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (residues 1 to 2703) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (residues 1 to 2703) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (residues 1 to 2703) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (residues 1 to 2703) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (residues 1 to 2703) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (residues 1 to 2703) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. The reference sequence is identical to AAF45848. On Nov 6, 2002 this sequence version replaced NP_476859.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## Method: conceptual translation. FEATURES Location/Qualifiers source 1..2703 /organism="Drosophila melanogaster" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" Protein 1..2703 /product="notch, isoform A" /name="CG3936 gene product from transcript CG3936-RA" /note="CG3936-PA; N-PA; chopped; strawberry; NICD; facet; confluens; notchoid; abruptex; split; dNotch" /calculated_mol_wt=288724 Region 179..214 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Region 217..252 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(217,220,234) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 260..291 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Region 295..329 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Region 331..369 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(331,334,351) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 449..486 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(449,452,467) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 488..524 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(488,491,505) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 526..562 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(526,529,543) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 564..600 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(564,567,581) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 602..637 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(602,605,618) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 640..675 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Region 677..713 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(677,680,694) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 715..750 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(715,718,732) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 753..789 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(753,756,770) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 791..827 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(791,794,808) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 829..865 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(829,832,846) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 907..943 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(907,910,925) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 946..982 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(946,949,963) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 984..1020 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(984,987,1001) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 1027..1058 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Region 1062..1095 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Region 1184..1219 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Region 1221..1257 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(1221,1224,1238) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 1259..1295 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(1259,1262,1276) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 1297..1335 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Site order(1297,1300,1316) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 1338..1373 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Region 1417..1450 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Region 1476..1512 /region_name="NL" /note="Domain found in Notch and Lin-12; smart00004" /db_xref="CDD:197463" Region 1519..1553 /region_name="Notch" /note="LNR domain; pfam00066" /db_xref="CDD:459658" Region 1565..1593 /region_name="Notch" /note="LNR domain; pfam00066" /db_xref="CDD:459658" Region 1598..1652 /region_name="NOD" /note="NOTCH protein; pfam06816" /db_xref="CDD:462014" Region 1679..1731 /region_name="NODP" /note="NOTCH protein; pfam07684" /db_xref="CDD:462229" Region 1719..1806 /region_name="JMTM_dNotch" /note="juxtamembrane and transmembrane (JMTM) domain found in Drosophila melanogaster neurogenic locus Notch protein (dNotch) and similar proteins; cd21706" /db_xref="CDD:411989" Site order(1720..1722,1725..1727,1747..1748,1750,1752..1760, 1763..1764,1767..1769) /site_type="other" /note="putative polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:411989" Region 1902..1948 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 1936..2139 /region_name="ANKYR" /note="Ankyrin repeat [Signal transduction mechanisms]; COG0666" /db_xref="CDD:440430" Region 1951..1981 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 1984..2015 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Site order(2017,2019,2023..2024,2027..2029,2031..2032,2036, 2039,2048,2050,2052,2056..2057,2060..2062,2064..2065,2069, 2072,2081,2083,2085,2089..2090,2093..2095,2097..2098,2102, 2105,2114) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:293786" Region 2017..2048 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 2050..2081 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 2083..2114 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" CDS 1..2703 /gene="N" /locus_tag="Dmel_CG3936" /gene_synonym="1.1; 16-178; 16-55; anon-EST:Liang-1.12; Ax; CG3936; Chp; clone 1.12; co; Co; CT13012; Dmel\CG3936; dNotch; EG:140G11.1; EG:163A10.2; fa; l(1)3Cb; l(1)Ax; l(1)N; nd; NECD; Nicd; NICD; notch; n[fah]; RICN; shd; spl; swb" /coded_by="NM_057511.4:799..8910" /db_xref="FLYBASE:FBpp0070483" /db_xref="GeneID:31293" /db_xref="FLYBASE:FBgn0004647" ORIGIN 1 mqsqrsrrrs rapntwicfw inkmhavasl paslpllllt lafanlpntv rgtdtalvaa 61 sctsvgcqng gtcvtqlngk tycacdshyv gdycehrnpc nsmrcqnggt cqvtfrngrp 121 gisckcplgf deslceiavp nacdhvtcln ggtcqlktle eytcacangy tgercetknl 181 casspcrnga tctalagsss ftcscppgft gdtcsydiee cqsnpckygg tcvnthgsyq 241 cmcptgytgk dcdtkykpcs pspcqnggic rsnglsyeck cpkgfegknc eqnyddclgh 301 lcqnggtcid gisdytcrcp pnftgrfcqd dvdecaqrdh pvcqngatct nthgsyscic 361 vngwagldcs nntddckqaa cfygatcidg vgsfycqctk gktgllchld dactsnpcha 421 daicdtspin gsyacscatg ykgvdcsedi decdqgspce hngicvntpg syrcncsqgf 481 tgprcetnin eceshpcqne gsclddpgtf rcvcmpgftg tqceididec qsnpclndgt 541 chdkingfkc scalgftgar cqiniddcqs qpcrnrgich dsiagyscec ppgytgtsce 601 inindcdsnp chrgkciddv nsfkclcdpg ytgyicqkqi necesnpcqf dghcqdrvgs 661 yycqcqagts gkncevnvne chsnpcnnga tcidginsyk cqcvpgftgq hceknvdeci 721 sspcanngvc idqvngykce cprgfydahc lsdvdecasn pcvnegrced ginefichcp 781 pgytgkrcel didecssnpc qhggtcydkl nafscqcmpg ytgqkcetni ddcvtnpcgn 841 ggtcidkvng ykcvckvpft grdceskmdp casnrcknea kctpssnfld fsctcklgyt 901 grycdedide cslsspcrng asclnvpgsy rclctkgyeg rdcaintddc asfpcqnggt 961 cldgigdysc lcvdgfdgkh cetdinecls qpcqngatcs qyvnsytctc plgfsgincq 1021 tndedctess clnggscidg ingyncscla gysgancqyk lnkcdsnpcl ngatcheqnn 1081 eytchcpsgf tgkqcseyvd wcgqspceng atcsqmkhqf sckcsagwtg klcdvqtisc 1141 qdaadrkgls lrqlcnngtc kdygnshvcy csqgyagsyc qkeidecqsq pcqnggtcrd 1201 ligayecqcr qgfqgqncel niddcapnpc qnggtchdrv mnfscscppg tmgiiceink 1261 ddckpgachn ngscidrvgg fecvcqpgfv garcegdine clsnpcsnag tldcvqlvnn 1321 yhcncrpghm grhcehkvdf caqspcqngg ncnirqsghh cicnngfygk ncelsgqdcd 1381 snpcrvgncv vadegfgyrc ecprgtlgeh ceidtldecs pnpcaqgaac edllgdyecl 1441 cpskwkgkrc diydanypgw nggsgsgndr yaadleqqra mcdkrgctek qgngicdsdc 1501 ntyacnfdgn dcslginpwa nctanecwnk fkngkcneec nnaachydgh dcerklkscd 1561 slfdaycqkh ygdgfcdygc nnaecswdgl dcenktqspv laegamsvvm lmnveafrei 1621 qaqflrnmsh mlrttvrlkk dalghdiiin wkdnvrvpei edtdfarknk ilytqqvhqt 1681 giqiyleidn rkctecftha veaaeflaat aakhqlrndf qihsvrgikn pgdedngepp 1741 anvkyvitgi ilviialaff gmvlstqrkr ahgvtwfpeg frapaavmsr rrrdphgqem 1801 rnlnkqvamq sqgvgqpgah wsddesdmpl pkrqrsdpvs gvglgnnggy asdhtmvsey 1861 eeadqrvwsq ahldvvdvra imtppahqdg gkhdvdargp cgltplmiaa vrgggldtge 1921 diennedsta qvisdllaqg aelnatmdkt getslhlaar faradaakrl ldagadancq 1981 dntgrtplha avaadamgvf qillrnratn lnarmhdgtt plilaarlai egmvedlita 2041 dadinaadns gktalhwaaa vnnteavnil lmhhanrdaq ddkdetplfl aaregsyeac 2101 kalldnfanr eitdhmdrlp rdvaserlhh divrlldehv prspqmlsmt pqamigsppp 2161 gqqqpqlitq ptvisagngg nngngnasgk qsnqtakqka akkakliegs pdngldatgs 2221 lrrkasskkt saaskkaanl nglnpgqltg gvsgvpgvpp tnsaaqaaaa aaaavaamsh 2281 elegspvgvg mggnlpspyd tssmysnama aplangnpnt gakqppsyed ciknaqsmqs 2341 lqgngldmik ldnyaysmgs pfqqellngq glgmngngqr ngvgpgvlpg glcgmgglsg 2401 agngnsheqg lsppysnqsp phsvqsslal sphaylgsps paksrpslpt spthiqamrh 2461 atqqkqfggs nlnsllggan gggvvggggg ggggvgqgpq nspvslgiis ptgsdmgiml 2521 appqssknsa imqtispqqq qqqqqqqqqq hqqqqqqqqq qqqqqqqqlg glefgsagld 2581 lngfcgspds fhsgqmnpps iqssmsgssp stnmlspssq hnqqafyqyl tpssqhsggh 2641 tpqhlvqtld syptpspesp ghwssssprs nsdwsegvqs paannlyisg ghqankgsea 2701 iyi