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hemagglutinin/hemolysin-related protein [Escherichia coli O157:H7


LOCUS       NP_309309               1270 aa            linear   CON 12-FEB-2021
            str. Sakai].
ACCESSION   NP_309309
VERSION     NP_309309.2
DBLINK      BioProject: PRJNA226
            BioSample: SAMN01911278
DBSOURCE    REFSEQ: accession NC_002695.2
KEYWORDS    RefSeq.
SOURCE      Escherichia coli O157:H7 str. Sakai
  ORGANISM  Escherichia coli O157:H7 str. Sakai
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1
  AUTHORS   Hayashi,T., Makino,K., Ohnishi,M., Kurokawa,K., Ishii,K.,
            Yokoyama,K., Han,C.G., Ohtsubo,E., Nakayama,K., Murata,T.,
            Tanaka,M., Tobe,T., Iida,T., Takami,H., Honda,T., Sasakawa,C.,
            Ogasawara,N., Yasunaga,T., Kuhara,S., Shiba,T., Hattori,M. and
            Shinagawa,H.
  TITLE     Complete genome sequence of enterohemorrhagic Escherichia coli
            O157:H7 and genomic comparison with a laboratory strain K-12
  JOURNAL   DNA Res. 8 (1), 11-22 (2001)
   PUBMED   11258796
  REMARK    Erratum:[DNA Res 2001 Apr 27;8(2):96]
REFERENCE   2
  AUTHORS   Yokoyama,K., Makino,K., Kubota,Y., Watanabe,M., Kimura,S.,
            Yutsudo,C.H., Kurokawa,K., Ishii,K., Hattori,M., Tatsuno,I.,
            Abe,H., Yoh,M., Iida,T., Ohnishi,M., Hayashi,T., Yasunaga,T.,
            Honda,T., Sasakawa,C. and Shinagawa,H.
  TITLE     Complete nucleotide sequence of the prophage VT1-Sakai carrying the
            Shiga toxin 1 genes of the enterohemorrhagic Escherichia coli
            O157:H7 strain derived from the Sakai outbreak
  JOURNAL   Gene 258 (1-2), 127-139 (2000)
   PUBMED   11111050
REFERENCE   3
  AUTHORS   Ohnishi,M., Murata,T., Nakayama,K., Kuhara,S., Hattori,M.,
            Kurokawa,K., Yasunaga,T., Yokoyama,K., Makino,K., Shinagawa,H. and
            Hayashi,T.
  TITLE     Comparative analysis of the whole set of rRNA operons between an
            enterohemorrhagic Escherichia coli O157:H7 Sakai strain and an
            Escherichia coli K-12 strain MG1655
  JOURNAL   Syst. Appl. Microbiol. 23 (3), 315-324 (2000)
   PUBMED   11108008
REFERENCE   4
  AUTHORS   Makino,K., Yokoyama,K., Kubota,Y., Yutsudo,C.H., Kimura,S.,
            Kurokawa,K., Ishii,K., Hattori,M., Tatsuno,I., Abe,H., Iida,T.,
            Yamamoto,K., Onishi,M., Hayashi,T., Yasunaga,T., Honda,T.,
            Sasakawa,C. and Shinagawa,H.
  TITLE     Complete nucleotide sequence of the prophage VT2-Sakai carrying the
            verotoxin 2 genes of the enterohemorrhagic Escherichia coli O157:H7
            derived from the Sakai outbreak
  JOURNAL   Genes Genet. Syst. 74 (5), 227-239 (1999)
   PUBMED   10734605
REFERENCE   5  (residues 1 to 1270)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (15-AUG-2018) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   6  (residues 1 to 1270)
  AUTHORS   Ogura,Y., Kurokawa,K., Hayashi,T. and Hattori,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-JUN-2000) Contact:Yoshitoshi Ogura Kyushu University;
            31-1 Maidashi Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to BAB34705.
            
            On Aug 15, 2018 this sequence version replaced NP_309309.1.
            On May 10, 2018 this sequence version replased gi: 47118301
            
            This update is obtained as follows: the Sakai genome was
            resequenced by illumina MiSeq and PacBio RS II sequencers and 78
            sites of single base error, 11 sites of insertion (10 one-base
            insertions and a 141-base insertion) and 16 sites of deletion (14
            one-base deletions, a three-base deletion and a six-base deletion)
            were corrected. Annotation was performed using DFAST
            auto-annotation system with manual curation.
            
            This work was done in collaboration with Tetsuya Hayashi, Makoto
            Ohnishi, Keisuke Nakayama (Miyazaki Medical College), Kozo Makino,
            Ken Kurokawa, Katsushi Yokoyama, Masashi Tanaka, Takeshi Honda,
            Teruo Yasunaga, Hideo Shinagawa (Osaka University), Takahiro Murata
            (Shinshu University), Chang-Gyun Han, Eiichi Ohtsubo, Toru Tobe,
            Chihiro Sasakawa (University of Tokyo), Hideto Takami (Japan Marine
            Science and Technology Center), Naotake Ogasawara (Nara Institute
            of Science and Technology), Satoru Kuhara (Kuyshu University), and
            supported by the Research for the Future Program of the Japan
            Society for the Promotion of Science.
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..1270
                     /organism="Escherichia coli O157:H7 str. Sakai"
                     /strain="Sakai"
                     /sub_strain="RIMD 0509952"
                     /serovar="O157:H7"
                     /db_xref="taxon:386585"
     Protein         1..1270
                     /product="hemagglutinin/hemolysin-related protein"
                     /calculated_mol_wt=130416
     Region          30..>1269
                     /region_name="FhaB"
                     /note="Large exoprotein involved in heme utilization or
                     adhesion [Intracellular trafficking, secretion, and
                     vesicular transport]; COG3210"
                     /db_xref="CDD:442443"
     Region          45..282
                     /region_name="TPS"
                     /note="TPS secretion domain; pfam05860"
                     /db_xref="CDD:461762"
     Region          287..306
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          308..329
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          331..349
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          351..371
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          374..394
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          396..413
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          415..434
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          436..455
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          464..482
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          484..508
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          510..528
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          530..549
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          554..570
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          572..590
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          592..611
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          631..649
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          651..671
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          673..692
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          694..722
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          724..742
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          744..763
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          766..783
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          787..805
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          808..824
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          826..864
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          866..885
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          887..906
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          908..927
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          929..947
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          950..968
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          970..989
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          991..1027
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          1029..1049
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          1051..1069
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          1072..1090
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          1102..1120
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          1122..1142
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          1143..1161
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          1163..1182
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          1184..1202
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     Region          1204..1222
                     /region_name="FHA beta-helical repeat"
                     /note="FHA beta-helical repeat [structural motif]"
                     /db_xref="CDD:293785"
     CDS             1..1270
                     /locus_tag="ECs_1282"
                     /coded_by="NC_002695.2:1350076..1353888"
                     /transl_table=11
                     /db_xref="GeneID:912619"
CONTIG      join(WP_001240839.1:1..1270)
ORIGIN      
        1 maminlskea tvgkaltpia ilmmlsfpva sqaaglvikn gtvynangvp vvdinkpngs
       61 glshniwdnl nvdkngvvfn nsanesstsl agniqgnsnl tsgsakviln evtsknpsti
      121 ngmmevagdk adliianpng itvngggsin tgkltlttgt pdiqddklag ysvnggtitl
      181 gkldnaspte ilsrnvvvng kvsadelnvv agnnyvnaag qvtgsvsatg srngysvdva
      241 klggmyanki slvstekgvg vrnlgviagg vngvsidskg nllnsnaqiq sastinlttn
      301 gtldnttgtv tsvgtislnt nkntivntra gnistmgdiy vnsgtidntn gklaaagmla
      361 vdtnnatlin sgkgssvgie aglvalktgt lnnsngqirg gyvglesaal nnnngdiqtt
      421 gdiaiisngn vdnnkglirs stghivigaa gsvnngstkt adtgssdslg iiadtgveig
      481 anninnnggq iasngnvsls systiddyag kilsnskvii kgsslrndtg gisgkqgiev
      541 avggsltnni gvisseegdi sllansvdnh ggfmmgqnit mesmsgvnnn talivaskkl
      601 kinargsien rdgnnfgnay glyfgmpqqt ggmvgkegie lsgqniynnn srliaedgpl
      661 tlqaqntfdn tralvtsgad asiqvggtyy nnyattwsag nldidattlq nsssgtmidn
      721 natgfiasdk nlslevvnsl tnygwisgkg dvdvtvnngn lynrntiaae kgldiaalng
      781 ienwkdisag gdltmntnrh vtnnsnsnmv gqnivinavn dinnrgnivs dadlnvttkg
      841 nlynylymvg ygdialsans vannnatiea tgdliidskg nvgnnrgnlh alngvlsvkg
      901 nnlnndngei rgygdvtlal tgnydsykgs ltsetgdvtl tanivdnayg liagenvsvd
      961 akstiynnta liaankklvi naggnlenrd gnnflrnnga lfgitdnvgg ivgkegvtls
     1021 aqnvynnnss iiaengplnl lsrgtldntr allssgadai iraagtfynn yattysagnl
     1081 dvyaaslnna sdgrlednta tgviasdknl dlsvdnsvtn ygwisgkgdv hfnvlkgtly
     1141 nrnaiaadna ltinalngve nfkdivagta ltidtqkyvt nnsnsnmlgq tiainavndi
     1201 nnrgnivgdy slgvkttgni ynylnmlsyg vagvsankvt nsgkdavlgg fyglaleane
     1261 tdntgtivgm