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LOCUS NP_001285103 3054 aa linear INV 26-DEC-2023 ACCESSION NP_001285103 VERSION NP_001285103.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 DBSOURCE REFSEQ: accession NM_001298174.1 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (residues 1 to 3054) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (residues 1 to 3054) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (residues 1 to 3054) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (residues 1 to 3054) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (residues 1 to 3054) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (residues 1 to 3054) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (residues 1 to 3054) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (residues 1 to 3054) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (residues 1 to 3054) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (residues 1 to 3054) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (residues 1 to 3054) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (residues 1 to 3054) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (residues 1 to 3054) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (residues 1 to 3054) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (residues 1 to 3054) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (residues 1 to 3054) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (residues 1 to 3054) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (residues 1 to 3054) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (residues 1 to 3054) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (residues 1 to 3054) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (residues 1 to 3054) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (residues 1 to 3054) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (residues 1 to 3054) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. The reference sequence is identical to AHN59573. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## Method: conceptual translation. FEATURES Location/Qualifiers source 1..3054 /organism="Drosophila melanogaster" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" Protein 1..3054 /product="myosin 10A, isoform F" /EC_number="5.6.1.8" /name="CG43657 gene product from transcript CG43657-RF" /note="CG43657-PF; Myo10A-PF; sisyphus; myosin XV; unconventional myosin class XV" /calculated_mol_wt=339069 Region 78..737 /region_name="MYSc_Myo15" /note="class XV mammal-like myosin, motor domain; cd01387" /db_xref="CDD:276838" Site order(105..110,112..114,155..162,203..204,209..213, 431..436) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:276838" Site order(105..110,112..114) /site_type="other" /note="purine-binding loop" /db_xref="CDD:276838" Site 155..162 /site_type="other" /note="P-loop" /db_xref="CDD:276838" Site 203..213 /site_type="other" /note="switch I region" /db_xref="CDD:276838" Site 378 /site_type="other" /note="putative phosphorylation site [posttranslational modification]" /db_xref="CDD:276838" Site 431..436 /site_type="other" /note="switch II region" /db_xref="CDD:276838" Site order(460..471,474..483) /site_type="active" /note="relay loop [active]" /db_xref="CDD:276838" Site 667..676 /site_type="other" /note="SH1 helix" /db_xref="CDD:276838" Site order(679..699,716..723,725..737) /site_type="other" /note="converter subdomain" /db_xref="CDD:276838" Region <737..>852 /region_name="PTZ00121" /note="MAEBL; Provisional" /db_xref="CDD:173412" Region 923..1080 /region_name="MyTH4" /note="MyTH4 domain; cl02480" /db_xref="CDD:470587" Region 1087..>1154 /region_name="Ubl1_cv_Nsp3_N-like" /note="first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins; cl28922" /db_xref="CDD:475130" Region 2613..2719 /region_name="MyTH4" /note="MyTH4 domain; pfam00784" /db_xref="CDD:459939" Region 2829..2934 /region_name="FERM_B-lobe" /note="FERM domain B-lobe; cd14473" /db_xref="CDD:271216" Region 2938..3047 /region_name="FERM_C_MyoXV" /note="FERM domain C-lobe of Myosin XV (MyoXV/Myo15); cd13201" /db_xref="CDD:270022" Site order(2946,2977,2979,2987) /site_type="other" /note="putative phosphoinositide binding site [chemical binding]" /db_xref="CDD:270022" Site order(2991,2996..2999,3036,3040,3043..3044) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:270022" Site 3036..3047 /site_type="other" /note="putative actin binding site 2 [polypeptide binding]" /db_xref="CDD:270022" CDS 1..3054 /gene="Myo10A" /locus_tag="Dmel_CG43657" /old_locus_tag="Dmel_CG16922" /old_locus_tag="Dmel_CG2174" /gene_synonym="10A; AAF47980; CG16922; CG2136; CG2174; CG43657; Dmel\CG43657; DmXV; myo10A; Myo20; Syph" /coded_by="NM_001298174.1:716..9880" /db_xref="FLYBASE:FBpp0312035" /db_xref="GeneID:32028" /db_xref="FLYBASE:FBgn0263705" ORIGIN 1 mdwaegdlvw fdpgmghpip geiqevhraa qvivvqalik gkpqtfalqp gegslrarqd 61 lgssgvedmt llddlheasl lwnlrlrydk gliytfagsi liavnpykmf pdayglevak 121 qyagrplgsl pphlfaigaa ahaalpspqv vvisgesgsg ktestklvmq ylaavvpggg 181 sasaviteqi leaaplleaf gnartarndn ssrfgkylev yfksgaivga kitqylleks 241 rivtqapger nyhvfyellg glsetersky glleadkyfy lnqgatdcas grvdweslqg 301 amqvlgvseg eregivrvla avlhlgnvyf hrrqlrhgqe gvevgsdaei kwaahllhis 361 adglhralts rttearaerl htplgidqal dardafakal yaglfnwlvs rinsivqkgg 421 thdahrisil difgfedlae nsfeqlciny anenlqlyfn khvfkleqae yarerlewtp 481 lawddnlpvi hllakkpvgi chllddesnf pratdlsfle kchynhalse lyarprigaq 541 efgvthyagq vwycvdgfld knrdalrgdv lellassrlp lvgeltkqlr aqrdagktlp 601 kgsngrfvtm kprtptvaar fadslqqllq smgrchpwfv rcikpnqekh alrmdmpcvl 661 qqlrylgmld tiqirqrgyp vrlrfqhfve ryrhllpspl argtpyrelc ralleamprt 721 gvegpdyqlg atrvflreal hralesgrte rlrraavsvq rhvrgmlvrr qlarrqaaat 781 rlqarwrgqr aqqryerlrk galtaqrlwr grqarrrvqq lrsdhrrrqe areaaqrare 841 areakqavle rsqlsyldip aelafiyskl qgwspphgdr hlvkvlgtvp gppssavqlp 901 edlgqfsfgk fssvycnglr lqprrepita plltraasrd qdfqdalavf klilrwsndk 961 alegakekll adyivhkals srglrdeilv qlcnqvhglp pnsgeatrlw qllgqclccf 1021 qpsaafskyl mrfvddeape slrplllrql lrqqgggtss gavgagacrs fvpawlewra 1081 wtrgcdmalp ltlpdeasqt vavdswtsce eaaalavssl gvasrgwtlv lddgqqltds 1141 cgldyvmdli aekelcpafp aprsdllrsg akfarttlpd avkrpavppp apptssgked 1201 vprerrssre llsrssalne ryferepspg pgqgsstgqa ksrskslddl lagdivpvpt 1261 dcdsqeplht lglsesrlnd ryhsaerlap vgkdtgpryq ksqhagrrsh aashgshssk 1321 yadkaeyatr ssamsdtsea pslashvrrv rvpsqasdvd qflddlfspv ldgsldelsd 1381 arslaasirg gsyeqeneae seiddlddyi ndifqpiplv qnlekltskd qlaaiikggg 1441 vaskpeerde eseiedlddy inelfepipv aegldkltsk ehlavsirgg gstdsngadp 1501 llhqlmqlpg etesgpalyq qqvqraflqs amaqnlqiqq qllaqnqalq tllsqqaaaa 1561 aannstsppp appilsslsi sppppqspmr mkatrsslvv meslqppppp ppppmppple 1621 ckdpsetrhf ldpygraktv rigkwrwppp qdepqfqtee dffafkmrqh qrkttpqaqh 1681 hqmtsnggmm esgpgargas ataieweefe iesptpppms gqlmrssirl etttttttsa 1741 vnnrdrdret qdvgqpmqsv vttklakksf eigadrpppg svgklklsse mrqrleqvta 1801 ghsvrstvst kseqrapakl edtrklmlqq qlgglfasvs ggnsgpggvv dshatvrtqi 1861 ermegklspp pappsggwpg vllppapsvp appppirpps mappapppap qspptarspe 1921 pepdyrtsss qvvkehvpaf iqrqerdtfg avrqqqmiss hhlhledhsa ssspavaawe 1981 qaerersrsr srsrdredys esvwdraeve gpasgsgsek erekrerere rlyeirqver 2041 ereshkvyqp apprviqasm dttgghrred rtgglatfrt hmaqkyeher krkssassgm 2101 reeldsmhmt tpppvivpap vpppsstspg lgvvsgvlmg sgsggstacl tynrvpwklr 2161 vrkevfqphe pigppvaldl lfaqvlgdvf gvtpclritp qekssalnml hghgvsvdtl 2221 snrngsgagg ggnggqvral vkrhlvdmar dwplyfarlf avqgaplypd vsimgvshsg 2281 lylarrdady livvqaisfg eiqsavtlpr paalqlnlrn gkhlalhaar aaaiqsmvtt 2341 fvqefrksqs kastlssgar aaaqtlnvpl erlesrqaha qrnehgvdgg srqneqlqqs 2401 elhhhlqqqq qqqqqqqhhq qqqqqqqled ameeqhmatd hqqqqqqqlg qqqgqqqrfl 2461 kqqsylhsar ksnagqqpss ltngqvhhqe qmlqqqqqqs qslphhdlda nylqdesngg 2521 tppsvtkysl lqfamqhfrn dqlrdadrhh erhqsaanrs yaelvkwqgh airlpllrlp 2581 ndlaplalec fdcilrycgd ipldpdltev kcvytvlmhc hkylalrdev ycqlmkqtta 2641 nrspcpdssq rawrllsila ayfgcsdalr pylmehltsa asdrrrschg taavcltnlr 2701 ktarcggrkn vpsveevtav sagrsarrqi yrlpggaerv vntrcstvva dviaelcall 2761 gveseaeqqe fslycivqgd aftmplaade yildvttell ksgqpfylif crsvwhfalk 2821 repapmplyv evlfnqvapd yleglllelp gngvpvpemv rdmariaall hraadlshvp 2881 amkeikfllp kpalgireir paqwvglvqs awpqvanlsp gqvkaqflnv latwplfgss 2941 ffavkriwae egphvednhs pmwrdlilal nrrgvlfldp nthetlqhws fmevistrkv 3001 rsedgalfld mkvgnlmqqr virvqteqah eisrlvrqyi tmaqisqrdk reln