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Ubr3 ubiquitin ligase, isoform C [Drosophila melanogaster].


LOCUS       NP_001259318            2218 aa            linear   INV 26-DEC-2023
ACCESSION   NP_001259318
VERSION     NP_001259318.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
DBSOURCE    REFSEQ: accession NM_001272389.1
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (residues 1 to 2218)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 2218)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 2218)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (residues 1 to 2218)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (residues 1 to 2218)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (residues 1 to 2218)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (residues 1 to 2218)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (residues 1 to 2218)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (residues 1 to 2218)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (residues 1 to 2218)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (residues 1 to 2218)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (residues 1 to 2218)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (residues 1 to 2218)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (residues 1 to 2218)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (residues 1 to 2218)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (residues 1 to 2218)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (residues 1 to 2218)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (residues 1 to 2218)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (residues 1 to 2218)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (residues 1 to 2218)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (residues 1 to 2218)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (residues 1 to 2218)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (residues 1 to 2218)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. The
            reference sequence is identical to AGB95163.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..2218
                     /organism="Drosophila melanogaster"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     Protein         1..2218
                     /product="Ubr3 ubiquitin ligase, isoform C"
                     /name="CG42593 gene product from transcript CG42593-RC"
                     /note="CG42593-PC; Ubr3-PC"
                     /calculated_mol_wt=246837
     Region          224..292
                     /region_name="UBR-box_UBR3"
                     /note="UBR-box found in ubiquitin-protein ligase
                     E3-alpha-3 (UBR3) and similar proteins; cd19673"
                     /db_xref="CDD:439071"
     Site            order(224,240,249,252,258,274,276,288)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:439071"
     Region          <1410..1477
                     /region_name="FliJ"
                     /note="Flagellar FliJ protein; pfam02050"
                     /db_xref="CDD:426581"
     Region          1601..1651
                     /region_name="RING-H2_UBR3"
                     /note="RING finger, H2 subclass, found in
                     ubiquitin-protein ligase E3-alpha-3 (UBR3) and similar
                     proteins; cd16483"
                     /db_xref="CDD:438146"
     Region          1721..2201
                     /region_name="PRT6_C"
                     /note="Proteolysis_6 C-terminal; pfam18995"
                     /db_xref="CDD:465944"
     CDS             1..2218
                     /gene="Ubr3"
                     /locus_tag="Dmel_CG42593"
                     /old_locus_tag="Dmel_CG1530"
                     /old_locus_tag="Dmel_CG1531"
                     /gene_synonym="CG1530; CG1531; CG42593; Dmel\CG42593;
                     ubr3; UBR3"
                     /coded_by="NM_001272389.1:1014..7670"
                     /db_xref="FLYBASE:FBpp0303731"
                     /db_xref="GeneID:31713"
                     /db_xref="FLYBASE:FBgn0260970"
ORIGIN      
        1 mdeddnlsna disiddeevv reqthhppmq edqeldnedg ssdvdlssvy vvppivsaps
       61 pasvriaggs tiggggvaag avptttdnsh spfhdwdssv aaaaappppp prtgptttts
      121 sgtaaesgaa salsddagak psfffgassf slrsrkevaa linteccrgs ptpdldsimd
      181 tlfnpgtpid nldniewirw liaggrtpqe fvkivrsydn hakcglvwvp hvvayrcrtc
      241 gispcmsicr dcfkkgnhtn hdfnmflsqa ggacdcgdts vmkaegfcsd hginnrvnrd
      301 pvpnnllava eaimpkllfr llqhfrehsd tplevqaits ysceefanml idlnnmgeim
      361 rkvmtrtlin pevyaffmea pcqdtrngrf lkanrekyed avnrfpnpep pdeyrdlpal
      421 gdklvhttll eefifwtfkf efpqtlvcfl lnmlpdqdyk ehltrtfvmh ysripsvlem
      481 srdpdtlsnr vvhmsvqlfs neslalkmvn elsllhvmii slklmmskil iqntlhdpnk
      541 nfhfvidctr qvmkdhcywp lvsdfnnvls hesvalvflr ddnlidmwfq flqmlqgmnv
      601 nvretashve fepnsyyaaf sceleasayp mwsiishlqd gthahlakki inycvttlhe
      661 wldsiyfmea rlsmeemmqa sfhfplhryl aafvcqavtk mgislndvlp srpyllpllm
      721 ihplrvqsff yeilagkwvr nglqikgqam tyiqanfcns madmdlfflq icatnlpqyf
      781 flqntielfd vgqwletapl kqpqkaeqss mlegfltfla tlvtsrtnlg ndeatqciie
      841 isallatenk thsqllelmp ersgnvhtkn fetflkklsv ykapssgsen leqglftpid
      901 evwekhydpl hvllravhrr dfqssldrft nyvkskdkmp asgnlwppfr lphalpatss
      961 fsdpckilns rifhstilsi ffravhtrdv sehllalavf lleiavetsd dvgsgtgdra
     1021 ppalaavves ssgpgyhgyg tgrheppklf hcyptdnlsc nlrhvvkkvs lksrdpqvit
     1081 ssyrsnpfys dldfeveadp eqsmrmigqg dpegdeatgg aglgmgahsr rnvsqalvpm
     1141 rvpgmevalp pdlsvvaetg vvirqdsned dllregnham dmsppaaldf hfplqqitlp
     1201 esgmevairr dlllaetnnm gaiaggaggg anasatppag asnemfsptt ptgsgmllpf
     1261 qrvqpvavps sgnmdivpsn amgaggsfts gvsgsgtgrr mnyetggark rsvdiaiggs
     1321 nkdelhldes ilslllklhs qlsgtldsfs lsdgedqssd ddstmdvdcn eastsmaaae
     1381 stalaergrs krnyknihvs ssrigdgpff ignllrkiak qdeqcaqsid dirarlwpnq
     1441 rekqaeakar eakekeerrk karerqqkmm qdfankqklf mqsaaasssg mgygpededd
     1501 eelyeeqpre keydciicnc ttpstesnpi glvvlvessg ivghrrriae rlplpinaed
     1561 esrlahttrl aaefnrrtel lslkfgdesw ylsnnmaydn gvhvqscghh vhlscleayl
     1621 ktlyttqrqp vqdrgefycp vcrqlsnsvl plspqldrpt hlvrsgnqpf erlvadltdl
     1681 ikenetippt klteamgham evmtniaqrk vkcssitfrk lfifvtsiar tnleaeiiqr
     1741 ggslctanat rykpkreciv pllhvlsvhv rvlvewplws swaslaglpv tateplpahc
     1801 lelipsilad pialllkfil laplqldqdy ftcmvkvmyn llyyqivvql cvtltdlecd
     1861 hivkvygsts vgsdnsaaes qqqesaagtt nnrrragqqq qsssqlgkam alvlsqtndl
     1921 vhlrrdcips tsssaaasaa gsssttstnh gasaatassa ttievnlksm elqlqalclp
     1981 flrvaallrq hlyrhempei sapglefvrl vyylelvtds mdwdcfnask glcfipgtet
     2041 tlpqfwcqql mevrppadtv relvlinqhs lwqqprllel preyerlfty yherpclncy
     2101 kvpkessicl lcgtivclkq nccaendcce avrhtlscgg gigiflvvts tyiivirgrr
     2161 aclwgslyld dfdeedrdlk rgkplylskd rfnllesqwl shkfahtkht wvfhrdll