Unfortunately due to lack of commercial feasibility, the SkyBLAST service has been suspended from December 1st, 2025.
All subscriptions for paid accounts have been paused. For further information or enquiries, please email [email protected]

phosphatidylinositol 4-kinase III alpha, isoform D [Drosophila


LOCUS       NP_001259191            2154 aa            linear   INV 26-DEC-2023
            melanogaster].
ACCESSION   NP_001259191
VERSION     NP_001259191.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
DBSOURCE    REFSEQ: accession NM_001272262.2
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (residues 1 to 2154)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 2154)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 2154)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (residues 1 to 2154)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (residues 1 to 2154)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (residues 1 to 2154)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (residues 1 to 2154)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (residues 1 to 2154)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (residues 1 to 2154)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (residues 1 to 2154)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (residues 1 to 2154)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (residues 1 to 2154)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (residues 1 to 2154)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (residues 1 to 2154)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (residues 1 to 2154)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (residues 1 to 2154)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (residues 1 to 2154)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (residues 1 to 2154)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (residues 1 to 2154)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (residues 1 to 2154)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (residues 1 to 2154)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (residues 1 to 2154)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (residues 1 to 2154)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. The
            reference sequence is identical to AGB95037.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..2154
                     /organism="Drosophila melanogaster"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     Protein         1..2154
                     /product="phosphatidylinositol 4-kinase III alpha, isoform
                     D"
                     /EC_number="2.7.1.67"
                     /name="CG10260 gene product from transcript CG10260-RD"
                     /note="CG10260-PD; Pi4KIIIalpha-PD; lethal (1) 3Ah;
                     phosphatidylinositol 4-kinase IIIalpha; PI4KIIIalpha;
                     zeste-white 2"
                     /calculated_mol_wt=241905
     Region          386..1571
                     /region_name="PI4K_N"
                     /note="PI4-kinase N-terminal region; pfam19274"
                     /db_xref="CDD:437106"
     Region          1600..1775
                     /region_name="PI4Ka"
                     /note="Phosphoinositide 4-kinase(PI4K), accessory domain
                     (PIK domain); PIK domain is conserved in PI3 and
                     PI4-kinases. Its role is unclear but it has been suggested
                     to be involved in substrate presentation. PI4K
                     phosphorylates hydroxylgroup at position 4 on the...;
                     cd00871"
                     /db_xref="CDD:238443"
     Region          1836..2153
                     /region_name="PI4Kc_III_alpha"
                     /note="Catalytic domain of Type III Phosphoinositide
                     4-kinase alpha; cd05167"
                     /db_xref="CDD:270711"
     Site            order(1848,1850..1851,1853,1855,1900,1902,1905,1936,
                     1948..1951,1956,1959,2014,2016,2026..2027)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270711"
     Site            2006..2014
                     /site_type="active"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:270711"
     Site            order(2027..2037,2040..2043,2044..2049)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270711"
     CDS             1..2154
                     /gene="Pi4KIIIalpha"
                     /locus_tag="Dmel_CG10260"
                     /gene_synonym="CG10260; Dmel\CG10260; EG:BACR7C10.2;
                     l(1)17-59; l(1)3Ah; l(1)VA722; l(1)zw2; PI4K; PI4KIIIA;
                     PI4KIIIalpha; PI4KIII[[alpha]]; PI4KinaseIIIalpha; stt4;
                     Stt4; zw-2; ZW-2; zw2"
                     /coded_by="NM_001272262.2:215..6679"
                     /db_xref="FLYBASE:FBpp0303977"
                     /db_xref="GeneID:31247"
                     /db_xref="FLYBASE:FBgn0267350"
ORIGIN      
        1 mtmtasdkyt yqrtvlclar vlagiqptpw dkvqtlfryc pqenaagvfc ldtraqdavi
       61 algiyflegg cqhegqivpy llrlakclpk avwiddarsn kvervripsa ekfsfclntl
      121 lsdiaakcpd sreeiilnqv etlsalaniv kssrdsssap ppiilckatv pllfglarsm
      181 gryasndppl lcrifppell piqkgggrdg tgssssasgt cggsfssser laathhfrpi
      241 iprsmsgsla qaqnasyddg rqrcaggkps kpslhsyfsv pydprthfft rygssfnqfp
      301 nmrvcesptk ggprplyrvp pfpiqhlqti favskklltk dtlehldeqa sdifslhqik
      361 gycyksfset lnlvlvtllr ellqhqvdlp tpftkdvqef vkrlflngqt elqnkqqdqe
      421 rerreengia vvnkykvnvm anaacvdllv wairdetvdv dynvpslqng lqfllkkead
      481 klcgrlsqkl nlelshkivm dhmpllmvcl eglgklahkf pniagtsisy lrdflvapsp
      541 ilgklhdham qslaqqkkek eltpfkiavq hsdsrtavvi ygdnqkppgs gtgrsghaaf
      601 eslrdaaien lsialraaht ldqfcvpalv anvsnrlfta eksgsesqge chksnlvsln
      661 iivmlghvav alkdtskttq nilqffiqrf ckvpseqnal ivdqlgcmii sqcethvfde
      721 imkmfsrvtv qsaslaytsd pehrkqfhhv sdavvnalgn iaaniqgdae mlellgklle
      781 lfvqigldge rsydntpgaq kassragnlg mlipviavlv rrlppiknpr qrlhklfkdf
      841 waycvvmgft narlwpadwy qgvqqiaaks pllisqtahk sdmrelnytl aiksdsvnel
      901 rsqilvlleh ssdnvatain klsfaqctyl lsvywlemlr venadepsle pimsylcdta
      961 lqrdktgiwq cvkcvadqvf ekfrnvlyah deirekvles qatlllvyfn hihkpiqmva
     1021 dqylsflvdr fphllwnrrv lwcmldilql layslsldpn eetptlrvvs tpytlqlmds
     1081 lparelrlkd fadrcqgivn eamkwaprst rshlqeypnq iptpvlahhs glalafdsvv
     1141 sssaqhtgtm skrpscvnsd tprfvsvlcl rskyageisg llsvlsekdk agladrlvsd
     1201 vweacaeksd arhrgalwra tayliicsei srkllhavas sqlelftesa metavecwqw
     1261 vltarqdlel cfiqemvsaw qttfekrmgl fawetevthp laayegcklv skpiliaphl
     1321 iwlqllsemv dtakycnrdk vemfclllhr clpvlksskq nrqvstvgcr fkllqcglsl
     1381 lqgntipksl srnilreriy snaldyfcgp ptcpnqsreq lledimillk fwqtmrsekk
     1441 hlvtsevgdy dltnasvsst qmlavrnnpe taslisgggl vndytrsmsa sgnavgmgmg
     1501 vagggsssgw yntiphstst lskrsnrskr lqyqkdsydk dymkkrnlil ellavelefl
     1561 itwynpnslp dlivpgeeqi tewrnrpyks tvwrdyarla wcynpalavf lpqriknaei
     1621 ideevsrlvc sdpiavchip ealkylcttk nllqespdlv yilswspvtp iqalayfsrq
     1681 ypshpltaqy avktlssypa esvlpyipql vqalrhdtmg yvvefiknis rrsqivahql
     1741 iwnmqtnmym dedqqhkdpn lyealdqlsq siiasfsgaa krfyerefdf fgkitavsge
     1801 irsfakgier knaclaalsr ikvqggcylp snpeamvldi dyssgtpmqs aakapylarf
     1861 rvyrcgitel etramevsnn pnsqedakmt lgveswqaai fkvgddvrqd mlalqvitif
     1921 knifqqvgld lflfpyrvva tapgcgviec vpnaksrdql grqtdsglse yfqhqygdes
     1981 skefqaaran fvksmaaysl igyllqikdr hngnimidkd ghiihidfgf mfesspggni
     2041 gfepdmkltd emvmimggkm dspafkwfce lcvqaflavr pyqdaivslv slmldtglpc
     2101 frgqtinllk qrfvatknnk eaaahmlavi rnsyqnfrtr tydmiqyyqn qipy