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LOCUS NP_001245601 2574 aa linear INV 26-DEC-2023 ACCESSION NP_001245601 VERSION NP_001245601.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 DBSOURCE REFSEQ: accession NM_001258672.2 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (residues 1 to 2574) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (residues 1 to 2574) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (residues 1 to 2574) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (residues 1 to 2574) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (residues 1 to 2574) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (residues 1 to 2574) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (residues 1 to 2574) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (residues 1 to 2574) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (residues 1 to 2574) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (residues 1 to 2574) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (residues 1 to 2574) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (residues 1 to 2574) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (residues 1 to 2574) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (residues 1 to 2574) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (residues 1 to 2574) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (residues 1 to 2574) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (residues 1 to 2574) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (residues 1 to 2574) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (residues 1 to 2574) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (residues 1 to 2574) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (residues 1 to 2574) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (residues 1 to 2574) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (residues 1 to 2574) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. The reference sequence is identical to AFH07315. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## Method: conceptual translation. FEATURES Location/Qualifiers source 1..2574 /organism="Drosophila melanogaster" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" Protein 1..2574 /product="chitinase 6, isoform I" /EC_number="3.2.1.-" /EC_number="3.2.1.14" /name="CG43374 gene product from transcript CG43374-RI" /note="CG43374-PI; Cht6-PI" /calculated_mol_wt=281465 Region 32..404 /region_name="GH18_chitolectin_chitotriosidase" /note="This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active...; cd02872" /db_xref="CDD:119351" Site order(35,39,111..112,150,152..153,199..200,223,225..226, 231,282,284,312,378) /site_type="active" /db_xref="CDD:119351" Region 506..562 /region_name="CBM_14" /note="Chitin binding Peritrophin-A domain; pfam01607" /db_xref="CDD:426342" Region <1738..1845 /region_name="PHA03247" /note="large tegument protein UL36; Provisional" /db_xref="CDD:223021" Region 2251..>2452 /region_name="MSCRAMM_ClfA" /note="MSCRAMM family adhesin clumping factor ClfA; NF033609" /db_xref="CDD:468110" CDS 1..2574 /gene="Cht6" /locus_tag="Dmel_CG43374" /old_locus_tag="Dmel_CG15313" /old_locus_tag="Dmel_CG15314" /old_locus_tag="Dmel_CG2989" /gene_synonym="CG15313; CG15314; CG2989; CG43374; Cht; cht6; CT5624; DmCht6; Dmel\CG43374" /coded_by="NM_001258672.2:187..7911" /db_xref="FLYBASE:FBpp0298362" /db_xref="GeneID:31935" /db_xref="FLYBASE:FBgn0263132" ORIGIN 1 mlpfrrgaaw qtlfllcala ycineasseg rvvcyytnws vyrpgtakfn pqninpylct 61 hlvyafggft kdnqmkpfdk yqdieqggya kftglktynk qlktmiaigg wneassrfsp 121 lvasnerrqq fiknilkflr qnhfdgidld weypahregg ksrdrdnyaq fvqelraefe 181 reaektgrtr llltmavpag ieyidkgydv pklnkyldwf nvltydfhss hepsvnhhap 241 lysleedsey nydaelnidy sikyylkaga drdklvlgip tygrsytlin eestelgapa 301 egpgeqgdat rekgylayye icqtlkddpe wtvvqpnanv mgpyayrrnq wvgyddeaiv 361 rkkaeyvvaq glggimfwai dnddfrgtcn gkpyplieaa keamvealgl ginevakpsg 421 pqkpsrsrsr dnasnrnrln gkteaplssr rpsatrrpav sstqapppst tfklteaegs 481 slyiggrast tppppttpdp gsdfkceeeg ffqhprdckk yywcldsgps glgivahmft 541 cpsglyfnpa adscdfarnv pcktkkstta apvtsttpat ttvrsnrvta aptsrpvypr 601 tttttstttt ttttpstvde dleyeedtde lspskstdae edpqvikeli dlirkvggve 661 qlekhllrnk dgsitlkens atgaattpst iskslydrvl srpgtlnsfs rnrfkiseas 721 etstepttss sssrgsstlt sntnskyssv lrgnsrqgpq negieklaef dgflkerkqy 781 vtinrhrsas qgdeeehadq qeeeenlaev etttrrplss itpsytslrr srpttvappa 841 eesheeaeqq tqtqvksyat lsrtrgrtts spevteaaps sttnrykyfe rtrptksata 901 edsedptede eeeyedeqkd ivtvqskqst ntrkyasigr rttttttatp ettttttttt 961 agtetakast ttnnnnnnns hynssnnnnn vklnnqlpte enitttpstt aqsetttttn 1021 ettepnests ttttsitnnl htttttptpi vastvpttta ngissdslla telseaspth 1081 lspspdsets tptttstttt eqpeldtttt tpkttttttt gnnelndvnn vdedsevtkt 1141 ktqykyattn rrritttttt atknsnnnnn aeaandaspt tnglsslnsi rtnpgrrqpq 1201 peqtqtttse pnlssprpfg yprrrtrptv stttttisqt dndnntdnnd netdavaqvv 1261 kktrlspgdr pknryqlsrt rgstttntnp tttqqpqtts tarrlafggr qraqvtkltl 1321 vdeqteetet kgdsreeeke eeeeedsnat ttttttttsr ptpkrirvlk frrplnsnsn 1381 stinvdsttn satdtnpdtt tatpttagqs ttsnsnnnnn nttsttgnkr frkivrklrp 1441 vdsstaasvd nsdettrkpf vpshtrfadq dndlvnlrqr ikeqqargep qdgvisnrfk 1501 tlgqkddqdv selqklrdkv kaeqargege qgvindrlkk llaekgssis sqreesstdd 1561 dsssvssarp ffkrklvarr pytppsasgg ttkapltfst srptakfvrr kngrfdpfns 1621 svrnrgegfv rsdprgsrlp gtdrfksqgn sedddeveer heqplqnqfa ttlrrpfvpk 1681 trpvldkskp eqedgaeese eedeeedsee egdeeedeee edvkpggeed naqednkpkf 1741 nspykpkdnr appgsrptfg ttgsgsppta sgnvpynprn rpsnsangns tpsnrfgttk 1801 rprvvnrppg vaspnltlkp vasdyerttp ltplkpapfi psnnrsyerk ysgpsteaae 1861 tasenslied lnidalnarn kkifdkhskk hpalkpkvvk vesetgleve agtevavede 1921 tteeqqqeqg fvtttpstpp spappstqsd tatttdtppe tetetetete tetetenvte 1981 ietatnanea tsinsqdqti ssttqapppa ttllhvftll egegqeeept trkptvrlyp 2041 tiqtevvpkh klieinrive inskqakaaq rkskanhdfs tlmveslphv eqlgeisvvk 2101 yvhlvdgsdi qindghstva dytpteptsa aerpvslpvr nslpetegad tdrsgkslvp 2161 evltaalets tisleglfds arkgkqlssn tiigeteest tigsssslas etgetttpap 2221 tyvrpivpll rpesnesspl visianldqv ilskvqksla ensqttvape aasdsnsafs 2281 vrqplvvqap isngaqeidq dtlntqdqti ngaisvktnp iiqtttnrpn ddqvaeetti 2341 fsietatepe lntqttipkt eansetvtam pigavimgqf glntqsttav dndnqlnaqt 2401 tstissgavs svaiggntqt anadnarqen tqstgtitse issgaissdn hnhigtqtta 2461 tidsssettp tqisttissg aisghidgsi nlntqtntti stnntttstt dvgskvseav 2521 sfssethvvh rkkmgrkgrg rrlrnrkttt tttttetptt teatfddttt vvpe