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LOCUS NP_001245495 4176 aa linear INV 26-DEC-2023 ACCESSION NP_001245495 VERSION NP_001245495.2 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 DBSOURCE REFSEQ: accession NM_001258566.4 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (residues 1 to 4176) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (residues 1 to 4176) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (residues 1 to 4176) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (residues 1 to 4176) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (residues 1 to 4176) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (residues 1 to 4176) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (residues 1 to 4176) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (residues 1 to 4176) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (residues 1 to 4176) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (residues 1 to 4176) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (residues 1 to 4176) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (residues 1 to 4176) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (residues 1 to 4176) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (residues 1 to 4176) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (residues 1 to 4176) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (residues 1 to 4176) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (residues 1 to 4176) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (residues 1 to 4176) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (residues 1 to 4176) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (residues 1 to 4176) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (residues 1 to 4176) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (residues 1 to 4176) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (residues 1 to 4176) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. The reference sequence is identical to AFH07209. On Jul 15, 2014 this sequence version replaced NP_001245495.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## Method: conceptual translation. FEATURES Location/Qualifiers source 1..4176 /organism="Drosophila melanogaster" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" Protein 1..4176 /product="terribly reduced optic lobes, isoform AK" /name="CG33950 gene product from transcript CG33950-RAK" /note="CG33950-PAK; trol-PAK; lethal (1) G0271; Trol/perlecan; mRNA-like ncRNA in embryogenesis 7; lethal (1) G0211; lethal (1) G0181; lethal (1) G0412; terribly reduced optic lobes; dPerlecan; lethal (1) G0023; lethal (1) G0374; lethal (1) G0019; lethal (1) G0021" /calculated_mol_wt=461025 Region 36..68 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(41,49,60..61) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(53,56,60,66..67) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 63..67 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 75..110 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(80,89,100..101) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(93,96,100,106..107) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 103..107 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 121..156 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(126,134,145..146) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(138,141,145,152..153) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 149..153 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 158..193 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(163,171,182..183) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(175,178,182,189..190) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 186..190 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 202..236 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(207,215,226..227) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(219,222,226,232..233) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 229..233 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 290..325 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(295,304,315..316) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(308,311,315,321..322) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 318..322 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 399..433 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(405,413,424..425) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(417,420,424,430..431) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 427..431 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 438..473 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(443,452,463..464) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(456,459,463,469..470) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 466..470 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 488..522 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(493,501,512..513) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(505,508,512,518..519) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 515..519 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 542..576 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(547,555,566..567) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(559,562,566,572..573) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 569..573 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 583..616 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(588,595,606..607) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(599,602,606,612..613) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 609..613 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 619..653 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(624,632,643..644) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(636,639,643,649..650) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 646..650 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 658..691 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(663,670,681..682) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(674,677,681,687..688) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 684..688 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 719..751 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(724,732,743..744) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(736,739,743,749..750) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 746..750 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 768..801 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(773,780,791..792) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(784,787,791,797..798) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 794..798 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 807..837 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(808,816,827..828) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(820,823,827,833..834) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 830..834 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 838..872 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(843,851,862..863) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(855,858,862,868..869) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 865..869 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 878..912 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(883,891,902..903) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(895,898,902,908..909) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 905..909 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 946..981 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(951,959,970..971) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(963,966,970,977..978) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 974..978 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1007..1068 /region_name="Ig" /note="Immunoglobulin domain; cl11960" /db_xref="CDD:472250" Region 1018..1022 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 1032..1035 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 1051..1055 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 1102..1136 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1107,1115,1126..1127) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1119,1122,1126,1132..1133) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1129..1133 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1142..1176 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1147,1155,1166..1167) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1159,1162,1166,1172..1173) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1169..1173 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1185..1219 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1190,1198,1209..1210) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1202,1205,1209,1215..1216) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1212..1216 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1237..1312 /region_name="Ig_Perlecan_like" /note="Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins; cd05743" /db_xref="CDD:143220" Region 1240..1246 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:143220" Region 1253..1258 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:143220" Region 1276..1280 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:143220" Region 1289..1295 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:143220" Region 1304..1310 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:143220" Region 1411..1541 /region_name="Laminin_B" /note="Laminin B (Domain IV); pfam00052" /db_xref="CDD:459652" Region 1598..1652 /region_name="EGF_Lam" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055" /db_xref="CDD:238012" Site order(1598,1600,1612,1622,1624,1633) /site_type="active" /note="EGF-like motif [active]" /db_xref="CDD:238012" Region 1776..1912 /region_name="Laminin_B" /note="Laminin B (Domain IV); pfam00052" /db_xref="CDD:459652" Region <1913..1939 /region_name="EGF_Lam" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055" /db_xref="CDD:238012" Region 1947..1996 /region_name="EGF_Lam" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055" /db_xref="CDD:238012" Site order(1948,1950,1957,1964,1967,1976) /site_type="active" /note="EGF-like motif [active]" /db_xref="CDD:238012" Region <2032..2062 /region_name="Laminin_EGF" /note="Laminin EGF domain; pfam00053" /db_xref="CDD:395007" Region 2128..2262 /region_name="Laminin_B" /note="Laminin B (Domain IV); pfam00052" /db_xref="CDD:459652" Region 2414..2482 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 2425..2429 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 2441..2445 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 2460..2464 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 2474..2479 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 2506..2576 /region_name="Ig_3" /note="Immunoglobulin domain; pfam13927" /db_xref="CDD:464046" Region 2605..2673 /region_name="Ig_3" /note="Immunoglobulin domain; pfam13927" /db_xref="CDD:464046" Region 2702..2786 /region_name="Ig" /note="Immunoglobulin domain; cl11960" /db_xref="CDD:472250" Region 2719..2723 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:143259" Region 2732..2736 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:143259" Region 2751..2755 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:143259" Region 2765..2770 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:143259" Region 2778..2781 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:143259" Region 2804..2877 /region_name="I-set" /note="Immunoglobulin I-set domain; pfam07679" /db_xref="CDD:400151" Region 2809..2813 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 2822..2826 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 2843..2847 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 2857..2862 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 2870..2873 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:409353" Region 2880..2968 /region_name="Ig" /note="Immunoglobulin domain; cl11960" /db_xref="CDD:472250" Region 2900..2904 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 2913..2917 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 2934..2938 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 2948..2953 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 2961..2964 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:409353" Region 3013..3070 /region_name="Ig" /note="Immunoglobulin domain; cl11960" /db_xref="CDD:472250" Region 3016..3020 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3028..3031 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3048..3051 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3096..3172 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 3105..3109 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3118..3122 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3152..3157 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 3190..>3251 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 3195..3199 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3206..3218 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3234..3238 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3300..3362 /region_name="Ig" /note="Immunoglobulin domain; cl11960" /db_xref="CDD:472250" Region 3312..3316 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3324..3329 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3345..3349 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3393..3459 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 3401..3405 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3414..3418 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3433..3437 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3447..3452 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 3461..3464 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:409353" Region 3481..3626 /region_name="LamG" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110" /db_xref="CDD:238058" Region 3649..3681 /region_name="EGF" /note="EGF-like domain; pfam00008" /db_xref="CDD:394967" Region 3729..3882 /region_name="LamG" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110" /db_xref="CDD:238058" Region 3982..4135 /region_name="LamG" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110" /db_xref="CDD:238058" CDS 1..4176 /gene="trol" /locus_tag="Dmel_CG33950" /gene_synonym="anon-WO0153538.72; BcDNA:GM02481; CG12497; CG33675; CG33950; CG7981; CT23996; Dmel\CG33950; EG:BACR25B3.1; EG:BACR25B3.10; EG:BACR25B3.11; EG:BACR25B3.2; GC7891; l(1)3Ac; l(1)9-96; l(1)G0019; l(1)G0021; l(1)G0023; l(1)G0181; l(1)G0211; l(1)G0271; l(1)G0374; l(1)G0412; l(1)trol; l(1)VA51; l(1)zw1; l(1)zwl; MRE7; pcan; Pcan; Pcn; Perl; Perlecan; Trol; TROL; Trol-A; Trol-B; troll; Troll; zw-1; ZW-1; zw1" /coded_by="NM_001258566.4:192..12722" /db_xref="FLYBASE:FBpp0309646" /db_xref="GeneID:45320" /db_xref="FLYBASE:FBgn0284408" ORIGIN 1 mgrrlraafw llavliviek pqksvargty lsygecqane frcnngdcid arkrcnnvsd 61 csegedenee cpaacsgmey qcrdgtrcis vsqqcdghsd csdgddeehc dgivpklryt 121 cpkgkftcrd lscisivhrc dgradcpndr sdeegcpcly dkwqcddgtc iakellcngn 181 idcpedisde ryceggydse ecrfdefhcg tgecipmrqv cdniydcndy sdevncvege 241 eedrvgipig hqpwrpaskh ddwlhemdts eyqvyqpsnv yekansqnpc asnqfrctts 301 nvciplhlrc dgfyhcndms deksceqyqr htttrrpltl atptsrittq gpgllerrnt 361 ttateasrwp watktttiat ttsnpittvg vansppqtcl eniefachnr dcisiesvcd 421 gipdcgrned eddalckcsg dkykcqrggg cipksqvcdg kpqchdrsde sachlhgrln 481 ktrlgvkcle sqyqcgdgsc isgykrcngi hdcadasdey nciydyedty dtdpnnnpln 541 ecdilefecd ysqclplekk cdgyadcedm sdelecqsyt dhclesefec dsyclprdql 601 cngipncqdg sdernctfcr edaylcntge cvadnqrcng iadcadgsde rhcariycpp 661 nklacngtcv srrikcdgir dcldgydemy cpetnnhypt qnvnvirpkl gpnpipkscr 721 phewqcanle cidsslqcne ikdcsdgsde elsvcfgtat trlkpsdcsp eqfycdescy 781 nrsvrcnghv dcsdgsdevg cslpcpqhqc psgrcytese rcdrhrhced gsdeanccya 841 nqfrcnngdc vsgsapcngy secsdhsdel ncggtqeclp nqfrcnsgqc vsssvrcngr 901 tdcqdssdeq ncghrhtevs qglettgvft tsttsttamt plriicppts fkcengpcis 961 lglkcngrvd cpydgsdead cgqisndidp adsndrrpnq lnlktypdsq iikesrevif 1021 rcrdegpara kvkwsrpggr plppgftdrn grleipnirv edagtyvcea vgyasyipgq 1081 qvtvnlnver yndvgsrpes acteyqatcm ngecidkssi cdgnpdcsda sdeqscslgl 1141 kcqpnqfmcs nskcvdrtwr cdgendcgdn sdetscdpep sgapcrynef qcrsghcipk 1201 sfqcdnvpdc tdgtdevgcm aplpirpppq svslleyevl eltcvatgtp tptivwrlnw 1261 ghvpdkcesk syggtgtlrc pdmrpqdsga ysceiintrg thfvnpdtiv tvrpvrtdvc 1321 eagffnmlar kaeecvqcfc fgvakacdsa nlftyaihpp ilshrvvsve lsplrqivin 1381 eaapgqdllt llhgvqfrat nvhfsgretp ylalpadymg nqlksyggnl ryevnyrgsg 1441 rpvngpdvii tgnrftltyr vrtqpgqnnr vsipfvpggw qkpdgrkasr eeimmilanv 1501 dnilirlgyl dstarevdli nialdsagta dkglgsaslv ekcqcppgyv gdscescasg 1561 yvrqpggpwl ghcvpfipds cpsgtygdpr rgvpckecpc pltgsnnfas gcqqspdgdv 1621 vcrcnegytg rrceqcaagy qgnplaaggi crripdtscn vdgtysvhsn gtcqckdsvi 1681 geqcdtcksk sfhlnsftyt gciecfcsgv gldcdsstwy rdqvtstfgr srvdhgfvlv 1741 tnymqptpdt vpvsmaaepn alsfigsadq sgntlywslp aaflgnklss yggkltytls 1801 ysplpngims rnsapdvvik sgedlrlihy rksqvvpsva ntysveikes awqrgdevva 1861 nrehvlmals ditaiyikat yttstkeasl rqvtldvatp tnlgtprave veqcrcpegy 1921 lglsceqcap gyardpeggi ylglcrpcec nghskycnsd tgdceecsdn tegpscerca 1981 agyvgdatrg tiydcqpdeg ypipsppapg nqtlectayc qiegiydcrg neclckrnvi 2041 gdqcdqcrpg tyglsaqnqd gckecycsgl asqcrsaaly rqlipvdfil naplitdesg 2101 avqdtenlip disrnmytyt htsylpkyws lrgsvlgnql fsyggrlsys livesygnye 2161 rghdivlign glkliwsrpd gnenqeeynv rlhedeqwtr qdresarpas rsdfmtvlsd 2221 lqhiliratp rvptqstsig nvilesavtt rtpgathasd ielcqcpsgy vgtscescap 2281 lhyrdasgsc slcpcdvsnt escdlvsggy vecrckarwk gdrcreidts piiedppqic 2341 dlsrgfccsg fqfdiapnet isfndtlqiy kgnriignmt klrygcpsrd tndptdigte 2401 dpvltqiivs iqkpeitivp vggsmtlscs grmrwsnspv ivnwykensr lpenvevqgg 2461 nlylydlqvs dsgvyicqav nnetasvfkd tvsititkkd qlspaeivnl pshvtfeeyv 2521 nneiicevlg npaprvtwar vdghadaqst rtydnrlifd sprksdegry rcqaendqnr 2581 dekyvivyvq snppqpppqq drlyitpeei nglagesfql ncqftsvasl rydwshngrs 2641 lsssparnve irgntlevrd asesdsgvyt cvaydvrtrr nftesarvni drreeqpfgn 2701 kpiiesleqn iliiqgedys itceasgspy psikwakvhd fmpenvhisg nvltiygarf 2761 enrgvyscva endhgsdlss tsidieprer psvkivsapl qtfsvgapas lyctvegipd 2821 ptvewvrvdg qplsprhkiq spgymviddi qledsgdyec raknivgeat gvatitvqep 2881 tlvqiipdnr dlrltegdel sltcvgsgvp npevewvnem alkrdlyspp sntailkiyr 2941 vtkadagiyt chgkneagsd eahvrvevqe rrgdiggvdd dsdrdpinyn ppqqqnpgih 3001 qpgsnqllat digdnvtltc dmfqplntrw ervdgaplpr naytiknrle ivrveqqnlg 3061 qyrcngigrd gnvktyfvke lvlmplprir fypnipltve agqnldvhcq venvrpedvh 3121 wstdnnrplp ssvrivgsvl rfvsitqaaa geyrcsafnq ygnrsqiarv avkkpadfhq 3181 vpqsqlqrhr egeniqlqct vtdqygvraq dnvefnwfrd drrplpnnar tdsqilvltn 3241 lrpedagryi cnsydvdrgq qlpevsidlq vltatpppns piylppqlpa ksrdyslkld 3301 dqssnlrage stdvecyssd dtytdvvwer sdgaplsnnv rqvgnrlvis nvspsdagny 3361 vckcktdegd lyttsyklev edqphelkss kivyakvgan adlqcgades rqptyrwsrq 3421 ygqlqagrsl mneklsldsv qandagtyic taqyadgeta dfpnilvvtg aipqfrqepr 3481 symsfptlpn ssfkfnfelt frpengdgll lfngqtrgsg dyialslkdr yaefrfdfgg 3541 kpmlvraeep lalnewhtvr vsrfkrdgyi qvdeqhpvaf ptlqqipqld liedlyiggv 3601 pnwellpada vsqqvgfvgc isrltlqgrt velireakyk egitdcrpca qgpcqnkgvc 3661 lesqteqayt cicqpgwtgr dcaiegtqct pgvcgagrce ntendmeclc plnrsgdrcq 3721 yneilnehsl nfkgnsfaay gtpkvtkvni tlsvrpasle dsvilytaes tlpsgdylal 3781 vlrgghaell intaarldpv vvrsaeplpl nrwtrieirr rlgegilrvg dgperkakap 3841 gsdrilslkt hlyvggydrs tvkvnrdvni tkgfdgcisr lynfqkpvnl ladikdaani 3901 qscgetnmig gdedsdnepp vppptpdvhe nelqpyamap casdpcengg scseqedvav 3961 cscpfgfsgk hcqehlqlgf nasfrgdgyv elnrshfqpa leqsytsmgi vfttnkpngl 4021 lfwwgqeage eytgqdfiaa avvdgyveys mrldgeeavi rnsdirvdng erhiviakrd 4081 entailevdr mlhsgetrpt skksmklpgn vfvggapdle vftgfrykhn lngcivvveg 4141 etvgqinlss aavngvnanv cpanddplgg teppvv