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LOCUS NP_001245493 4434 aa linear INV 26-DEC-2023 ACCESSION NP_001245493 VERSION NP_001245493.2 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 DBSOURCE REFSEQ: accession NM_001258564.3 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (residues 1 to 4434) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (residues 1 to 4434) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (residues 1 to 4434) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (residues 1 to 4434) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (residues 1 to 4434) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (residues 1 to 4434) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (residues 1 to 4434) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (residues 1 to 4434) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (residues 1 to 4434) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (residues 1 to 4434) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (residues 1 to 4434) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (residues 1 to 4434) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (residues 1 to 4434) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (residues 1 to 4434) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (residues 1 to 4434) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (residues 1 to 4434) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (residues 1 to 4434) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (residues 1 to 4434) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (residues 1 to 4434) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (residues 1 to 4434) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (residues 1 to 4434) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (residues 1 to 4434) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (residues 1 to 4434) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. The reference sequence is identical to AFH07207. On Jul 15, 2014 this sequence version replaced NP_001245493.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## Method: conceptual translation. FEATURES Location/Qualifiers source 1..4434 /organism="Drosophila melanogaster" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" Protein 1..4434 /product="terribly reduced optic lobes, isoform AF" /name="CG33950 gene product from transcript CG33950-RAF" /note="CG33950-PAF; trol-PAF; lethal (1) G0271; Trol/perlecan; mRNA-like ncRNA in embryogenesis 7; lethal (1) G0211; lethal (1) G0181; lethal (1) G0412; terribly reduced optic lobes; dPerlecan; lethal (1) G0023; lethal (1) G0374; lethal (1) G0019; lethal (1) G0021" /calculated_mol_wt=491546 Region 407..440 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(412,419,430..431) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(423,426,430,436..437) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 433..437 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 492..524 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(497,505,516..517) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(509,512,516,522..523) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 519..523 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 531..566 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(536,545,556..557) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(549,552,556,562..563) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 559..563 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 576..610 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(581,589,600..601) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(593,596,600,606..607) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 603..607 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 664..699 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(669,678,689..690) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(682,685,689,695..696) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 692..696 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 773..807 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(779,787,798..799) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(791,794,798,804..805) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 801..805 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 812..847 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(817,826,837..838) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(830,833,837,843..844) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 840..844 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 862..896 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(867,875,886..887) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(879,882,886,892..893) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 889..893 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 916..950 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(921,929,940..941) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(933,936,940,946..947) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 943..947 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 957..990 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(962,969,980..981) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(973,976,980,986..987) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 983..987 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 993..1027 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(998,1006,1017..1018) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1010,1013,1017,1023..1024) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1020..1024 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1054..1086 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1059,1067,1078..1079) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1071,1074,1078,1084..1085) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1081..1085 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1103..1136 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1108,1115,1126..1127) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1119,1122,1126,1132..1133) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1129..1133 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1142..1172 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1143,1151,1162..1163) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1155,1158,1162,1168..1169) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1165..1169 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1173..1207 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1178,1186,1197..1198) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1190,1193,1197,1203..1204) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1200..1204 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1213..1247 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1218,1226,1237..1238) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1230,1233,1237,1243..1244) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1240..1244 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1265..1326 /region_name="Ig" /note="Immunoglobulin domain; cl11960" /db_xref="CDD:472250" Region 1276..1280 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 1290..1293 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 1309..1313 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 1360..1394 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1365,1373,1384..1385) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1377,1380,1384,1390..1391) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1387..1391 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1400..1434 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1405,1413,1424..1425) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1417,1420,1424,1430..1431) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1427..1431 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1443..1477 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1448,1456,1467..1468) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1460,1463,1467,1473..1474) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1470..1474 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1495..1570 /region_name="Ig_Perlecan_like" /note="Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins; cd05743" /db_xref="CDD:143220" Region 1498..1504 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:143220" Region 1511..1516 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:143220" Region 1534..1538 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:143220" Region 1547..1553 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:143220" Region 1562..1568 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:143220" Region 1669..1799 /region_name="Laminin_B" /note="Laminin B (Domain IV); pfam00052" /db_xref="CDD:459652" Region 1856..1910 /region_name="EGF_Lam" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055" /db_xref="CDD:238012" Site order(1856,1858,1870,1880,1882,1891) /site_type="active" /note="EGF-like motif [active]" /db_xref="CDD:238012" Region 2034..2170 /region_name="Laminin_B" /note="Laminin B (Domain IV); pfam00052" /db_xref="CDD:459652" Region <2171..2197 /region_name="EGF_Lam" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055" /db_xref="CDD:238012" Region 2205..2254 /region_name="EGF_Lam" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055" /db_xref="CDD:238012" Site order(2206,2208,2215,2222,2225,2234) /site_type="active" /note="EGF-like motif [active]" /db_xref="CDD:238012" Region <2290..2320 /region_name="Laminin_EGF" /note="Laminin EGF domain; pfam00053" /db_xref="CDD:395007" Region 2386..2520 /region_name="Laminin_B" /note="Laminin B (Domain IV); pfam00052" /db_xref="CDD:459652" Region 2671..2739 /region_name="Ig_3" /note="Immunoglobulin domain; pfam13927" /db_xref="CDD:464046" Region 2764..2834 /region_name="Ig_3" /note="Immunoglobulin domain; pfam13927" /db_xref="CDD:464046" Region 2863..2931 /region_name="Ig_3" /note="Immunoglobulin domain; pfam13927" /db_xref="CDD:464046" Region 2960..3044 /region_name="Ig" /note="Immunoglobulin domain; cl11960" /db_xref="CDD:472250" Region 2977..2981 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:143259" Region 2990..2994 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:143259" Region 3009..3013 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:143259" Region 3023..3028 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:143259" Region 3036..3039 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:143259" Region 3062..3135 /region_name="I-set" /note="Immunoglobulin I-set domain; pfam07679" /db_xref="CDD:400151" Region 3067..3071 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3080..3084 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3101..3105 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3115..3120 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 3128..3131 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:409353" Region 3138..3226 /region_name="Ig" /note="Immunoglobulin domain; cl11960" /db_xref="CDD:472250" Region 3158..3162 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3171..3175 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3192..3196 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3206..3211 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 3219..3222 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:409353" Region 3271..3328 /region_name="Ig" /note="Immunoglobulin domain; cl11960" /db_xref="CDD:472250" Region 3274..3278 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3286..3289 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3306..3309 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3354..3430 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 3363..3367 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3376..3380 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3410..3415 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 3448..>3509 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 3453..3457 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3464..3476 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3492..3496 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3558..3620 /region_name="Ig" /note="Immunoglobulin domain; cl11960" /db_xref="CDD:472250" Region 3570..3574 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3582..3587 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3603..3607 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3651..3717 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 3659..3663 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3672..3676 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3691..3695 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3705..3710 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 3719..3722 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:409353" Region 3739..3884 /region_name="LamG" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110" /db_xref="CDD:238058" Region 3907..3939 /region_name="EGF" /note="EGF-like domain; pfam00008" /db_xref="CDD:394967" Region 3987..4140 /region_name="LamG" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110" /db_xref="CDD:238058" Region 4199..4231 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Region 4240..4393 /region_name="LamG" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110" /db_xref="CDD:238058" CDS 1..4434 /gene="trol" /locus_tag="Dmel_CG33950" /gene_synonym="anon-WO0153538.72; BcDNA:GM02481; CG12497; CG33675; CG33950; CG7981; CT23996; Dmel\CG33950; EG:BACR25B3.1; EG:BACR25B3.10; EG:BACR25B3.11; EG:BACR25B3.2; GC7891; l(1)3Ac; l(1)9-96; l(1)G0019; l(1)G0021; l(1)G0023; l(1)G0181; l(1)G0211; l(1)G0271; l(1)G0374; l(1)G0412; l(1)trol; l(1)VA51; l(1)zw1; l(1)zwl; MRE7; pcan; Pcan; Pcn; Perl; Perlecan; Trol; TROL; Trol-A; Trol-B; troll; Troll; zw-1; ZW-1; zw1" /coded_by="NM_001258564.3:185..13489" /db_xref="FLYBASE:FBpp0309642" /db_xref="GeneID:45320" /db_xref="FLYBASE:FBgn0284408" ORIGIN 1 mmgspgsqas aiatsvgirs grrgqaggsl llrllavtfv laachapllt nakqisnlgd 61 dqdfmladde slqgindsew qlmgddiddg llddvdetlk pmetkseeed lptgnwfsqs 121 vhrvrrsinr lfgsddnqer grrqqrersq rnrdainrqk elrrrqkedh nrwkqmrmer 181 qlekqrlvkr tnhvvfnrat dprkrasdly deneasgyhe edttlyrtyf vvnepydney 241 rdresvqfqn lqklldddlr nffhsnyegn ddeeqeirst lerveptndn fkirvqlrie 301 lptsvndfgs klqqqlnvyn rienlsaatd gvfsftessd ieeeaidvtl pqeevegsgs 361 ddsscrgdat ftcprsgkti cdemrcdrei qcpdgedeey cnypnvcted qfkcddkcle 421 lkkrcdgsid cldqtdeagc inapepepep epepepepes epeaepepep epepesepeq 481 epepqvpean ecqanefrcn ngdcidarkr cnnvsdcseg edeneecpaa csgmeyqcrd 541 gtrcisvsqq cdghsdcsdg ddeehcdgsg ydseecrfde fhcgtgecip mrqvcdniyd 601 cndysdevnc vegeeedrvg ipighqpwrp askhddwlhe mdtseyqvyq psnvyekans 661 qnpcasnqfr cttsnvcipl hlrcdgfyhc ndmsdeksce qyqrhtttrr pltlatptsr 721 ittqgpglle rrntttatea srwpwatktt tiatttsnpi ttvgvanspp qtcleniefa 781 chnrdcisie svcdgipdcg rnededdalc kcsgdkykcq rgggcipksq vcdgkpqchd 841 rsdesachlh grlnktrlgv kclesqyqcg dgscisgykr cngihdcada sdeynciydy 901 edtydtdpnn nplnecdile fecdysqclp lekkcdgyad cedmsdelec qsytdhcles 961 efecdsyclp rdqlcngipn cqdgsdernc tfcredaylc ntgecvadnq rcngiadcad 1021 gsderhcetn nhyptqnvnv irpklgpnpi pkscrphewq canlecidss lqcneikdcs 1081 dgsdeelsvc fgtattrlkp sdcspeqfyc descynrsvr cnghvdcsdg sdevgcslpc 1141 pqhqcpsgrc ytesercdrh rhcedgsdea nccyanqfrc nngdcvsgsa pcngysecsd 1201 hsdelncggt qeclpnqfrc nsgqcvsssv rcngrtdcqd ssdeqncaad sndrrpnqln 1261 lktypdsqii kesrevifrc rdegparakv kwsrpggrpl ppgftdrngr leipnirved 1321 agtyvceavg yasyipgqqv tvnlnveryn dvgsrpesac teyqatcmng ecidkssicd 1381 gnpdcsdasd eqscslglkc qpnqfmcsns kcvdrtwrcd gendcgdnsd etscdpepsg 1441 apcrynefqc rsghcipksf qcdnvpdctd gtdevgcmap lpirpppqsv slleyevlel 1501 tcvatgtptp tivwrlnwgh vpdkcesksy ggtgtlrcpd mrpqdsgays ceiintrgth 1561 fvnpdtivtv rpvrtdvcea gffnmlarka eecvqcfcfg vakacdsanl ftyaihppil 1621 shrvvsvels plrqivinea apgqdlltll hgvqfratnv hfsgretpyl alpadymgnq 1681 lksyggnlry evnyrgsgrp vngpdviitg nrftltyrvr tqpgqnnrvs ipfvpggwqk 1741 pdgrkasree immilanvdn ilirlgylds tarevdlini aldsagtadk glgsaslvek 1801 cqcppgyvgd scescasgyv rqpggpwlgh cvpfipdscp sgtygdprrg vpckecpcpl 1861 tgsnnfasgc qqspdgdvvc rcnegytgrr ceqcaagyqg nplaaggicr ripdtscnvd 1921 gtysvhsngt cqckdsvige qcdtcksksf hlnsftytgc iecfcsgvgl dcdsstwyrd 1981 qvtstfgrsr vdhgfvlvtn ymqptpdtvp vsmaaepnal sfigsadqsg ntlywslpaa 2041 flgnklssyg gkltytlsys plpngimsrn sapdvviksg edlrlihyrk sqvvpsvant 2101 ysveikesaw qrgdevvanr ehvlmalsdi taiyikatyt tstkeaslrq vtldvatptn 2161 lgtpraveve qcrcpegylg lsceqcapgy ardpeggiyl glcrpcecng hskycnsdtg 2221 dceecsdnte gpscercaag yvgdatrgti ydcqpdegyp ipsppapgnq tlectaycqi 2281 egiydcrgne clckrnvigd qcdqcrpgty glsaqnqdgc kecycsglas qcrsaalyrq 2341 lipvdfilna plitdesgav qdtenlipdi srnmytytht sylpkywslr gsvlgnqlfs 2401 yggrlsysli vesygnyerg hdivligngl kliwsrpdgn enqeeynvrl hedeqwtrqd 2461 resarpasrs dfmtvlsdlq hiliratprv ptqstsignv ilesavttrt pgathasdie 2521 lcqcpsgyvg tscescaplh yrdasgscsl cpcdvsntes cdlvsggyve crckarwkgd 2581 rcreidtspi iedppqicdl srgfccsgfq fdiapnetis fndtlqiykg nriignmtkl 2641 rygcpsrdtn dptdigtedp vltqiivsiq kpeitivpvg gsmtlscsgr mrwsnspviv 2701 nwykensrlp envevqggnl ylydlqvsds gvyicqavnn etasvfkdtv sititkkdql 2761 spaeivnlps hvtfeeyvnn eiicevlgnp aprvtwarvd ghadaqstrt ydnrlifdsp 2821 rksdegryrc qaendqnrde kyvivyvqsn ppqpppqqdr lyitpeeing lagesfqlnc 2881 qftsvaslry dwshngrsls ssparnveir gntlevrdas esdsgvytcv aydvrtrrnf 2941 tesarvnidr reeqpfgnkp iiesleqnil iiqgedysit ceasgspyps ikwakvhdfm 3001 penvhisgnv ltiygarfen rgvyscvaen dhgsdlssts idieprerps vkivsaplqt 3061 fsvgapasly ctvegipdpt vewvrvdgqp lsprhkiqsp gymviddiql edsgdyecra 3121 knivgeatgv atitvqeptl vqiipdnrdl rltegdelsl tcvgsgvpnp evewvnemal 3181 krdlysppsn tailkiyrvt kadagiytch gkneagsdea hvrvevqerr gdiggvddds 3241 drdpinynpp qqqnpgihqp gsnqllatdi gdnvtltcdm fqplntrwer vdgaplprna 3301 ytiknrleiv rveqqnlgqy rcngigrdgn vktyfvkelv lmplprirfy pnipltveag 3361 qnldvhcqve nvrpedvhws tdnnrplpss vrivgsvlrf vsitqaaage yrcsafnqyg 3421 nrsqiarvav kkpadfhqvp qsqlqrhreg eniqlqctvt dqygvraqdn vefnwfrddr 3481 rplpnnartd sqilvltnlr pedagryicn sydvdrgqql pevsidlqvl tatpppnspi 3541 ylppqlpaks rdyslklddq ssnlragest dvecyssddt ytdvvwersd gaplsnnvrq 3601 vgnrlvisnv spsdagnyvc kcktdegdly ttsykleved qphelksski vyakvganad 3661 lqcgadesrq ptyrwsrqyg qlqagrslmn eklsldsvqa ndagtyicta qyadgetadf 3721 pnilvvtgai pqfrqeprsy msfptlpnss fkfnfeltfr pengdglllf ngqtrgsgdy 3781 ialslkdrya efrfdfggkp mlvraeepla lnewhtvrvs rfkrdgyiqv deqhpvafpt 3841 lqqipqldli edlyiggvpn wellpadavs qqvgfvgcis rltlqgrtve lireakykeg 3901 itdcrpcaqg pcqnkgvcle sqteqaytci cqpgwtgrdc aiegtqctpg vcgagrcent 3961 endmeclcpl nrsgdrcqyn eilnehslnf kgnsfaaygt pkvtkvnitl svrpasleds 4021 vilytaestl psgdylalvl rgghaellin taarldpvvv rsaeplplnr wtrieirrrl 4081 gegilrvgdg perkakapgs drilslkthl yvggydrstv kvnrdvnitk gfdgcisrly 4141 nfqkpvnlla dikdaaniqs cgetnmiggd edsdneppvp pptpdvhene lqpyamapca 4201 sdpcenggsc seqedvavcs cpfgfsgkhc qehlqlgfna sfrgdgyvel nrshfqpale 4261 qsytsmgivf ttnkpngllf wwgqeageey tgqdfiaaav vdgyveysmr ldgeeavirn 4321 sdirvdnger hiviakrden tailevdrml hsgetrptsk ksmklpgnvf vggapdlevf 4381 tgfrykhnln gcivvveget vgqinlssaa vngvnanvcp anddplggte ppvv