Unfortunately due to lack of commercial feasibility, the SkyBLAST service has been suspended from December 1st, 2025.
All subscriptions for paid accounts have been paused. For further information or enquiries, please email [email protected]
LOCUS NP_001162740 2313 aa linear INV 26-DEC-2023 ACCESSION NP_001162740 VERSION NP_001162740.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 DBSOURCE REFSEQ: accession NM_001169269.2 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (residues 1 to 2313) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (residues 1 to 2313) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (residues 1 to 2313) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (residues 1 to 2313) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (residues 1 to 2313) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (residues 1 to 2313) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (residues 1 to 2313) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (residues 1 to 2313) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (residues 1 to 2313) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (residues 1 to 2313) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (residues 1 to 2313) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (residues 1 to 2313) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (residues 1 to 2313) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (residues 1 to 2313) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (residues 1 to 2313) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (residues 1 to 2313) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (residues 1 to 2313) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (residues 1 to 2313) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (residues 1 to 2313) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (residues 1 to 2313) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (residues 1 to 2313) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (residues 1 to 2313) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (residues 1 to 2313) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. The reference sequence is identical to ACZ95275. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## Method: conceptual translation. FEATURES Location/Qualifiers source 1..2313 /organism="Drosophila melanogaster" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" Protein 1..2313 /product="SET domain containing 2, isoform B" /EC_number="2.1.1.370" /name="CG1716 gene product from transcript CG1716-RB" /note="CG1716-PB; Set2-PB; drosophila hypb" /calculated_mol_wt=256661 Region <660..783 /region_name="valS" /note="valyl-tRNA synthetase; Provisional; PRK14900" /db_xref="CDD:237855" Region 1309..1361 /region_name="AWS" /note="associated with SET domains; smart00570" /db_xref="CDD:197795" Region 1361..1502 /region_name="SET_SETD2" /note="SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; cd19172" /db_xref="CDD:380949" Site order(1372..1374,1391,1401,1405,1409,1414..1420, 1437..1441,1448..1450,1465,1476..1480,1482..1486, 1488..1492,1501) /site_type="active" /db_xref="CDD:380949" Site order(1372..1374,1414..1417,1437..1441,1478,1488..1492, 1501) /site_type="other" /note="SAM binding site" /db_xref="CDD:380949" Site order(1391,1401,1405,1416..1420,1448..1450,1465, 1476..1480) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:380949" Site order(1443,1490,1492,1497) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:380949" Region 1965..1994 /region_name="WW" /note="WW domain; pfam00397" /db_xref="CDD:459800" Region 2217..2306 /region_name="SRI" /note="SRI (Set2 Rpb1 interacting) domain; pfam08236" /db_xref="CDD:462404" CDS 1..2313 /gene="Set2" /locus_tag="Dmel_CG1716" /gene_synonym="CG1716; dHypb; Dmel\CG1716; dSet2; Hypb; SET-2; set2; SET2" /coded_by="NM_001169269.2:162..7103" /db_xref="FLYBASE:FBpp0290774" /db_xref="GeneID:32301" /db_xref="FLYBASE:FBgn0030486" ORIGIN 1 meesgppsnp spvasrgrgr grppkvalsa lgntpphinp slkhadaeas ptapedqdsg 61 qsecrrssrk kiikfdvrdl lnknrkahki qiearidsnp stghsqsgtt aastsmstat 121 asaasassaa tvsrlfsmfe mshqslpppp ppptaleifa kprptqsliv aqvtsepsav 181 ggahpvqtma glppvtprkr grprksqlad aaiiptvivp scsdsdtnst stttsnmssd 241 sgelpgfpiq kpksklrvsl krlklggrle ssdsgnspss sspeveppal qdenamderp 301 kqeqnlsrmv daeensdsds qiifieiete spkgeeeqee grpvevepqd lididmelak 361 qeptpdpeed ldeimvevls gppslwsadd eaeeeedatv qratppgkep aadscssapr 421 rsrrsaplsg ssrqgktlee tfaeiaaess kqileaeesq dqeeqhilid liedtlksdn 481 iaaslnkdif epkvetkatc gevvprpemv tedvyitegi aatleksavv tkpttemiae 541 tklsdevvie pplkdesdpk qtevelpesk pavnipkser ilsaevetts splvppecct 601 lesvsgpvll etslsteeks nenvettplk teaakedspp aapeeeasns seepnflled 661 yesnqeqvae demmkcnnqk gqkqtplpem kepekpvaet vskkekamen parsspaivd 721 kkvragemek kvvkstkgtv pekkmdskks caavtpakqk esgksakeai lkketekeks 781 sakldssspn tldkkgkdta qwspqlqtlp ksstkppqes apsvisktts nqpapkeeqh 841 aakkglsdns ppsvlkakek avsgfvecda mfkamdlana qlrldeknkk klkkvptkve 901 appkveppta vpvpgqkksl sgktslrrnt vyedspnler nsspssdsaq antsagklkp 961 skvkkkinpr rsticeaakd lrsssssstp trevaasspv stssdssskr ngskrttsdl 1021 dggskldqrr yticedrqpe taipvpltkr rfsmhpkasa nplhdtllqt agkkrgrkeg 1081 keslsrqnsl dssssasqga pkkkalksae ilsaallete ssestssgsk msrwdvqtsp 1141 eleaanpfgd iakfiedgvn llkrdkvded qrkegqdevk readpeedef aqrvanmetp 1201 attptpsptq snpedsastt tvlkeletgg gvrrshrikq kpqgprasqg rgvasvalap 1261 ismdeqlael anieaineqf lrseglntfq llkenfyrca rqvsqenaem qcdcfltgde 1321 eaqghlscga gcinrmlmie cgplcsngar ctnkrfqqhq cwpcrvfrte kkgcgitael 1381 lippgefime yvgevidsee ferrqhlysk drnrhyyfma lrgeavidat skgnisryin 1441 hscdpnaetq kwtvngelri gffsvkpiqp geeitfdyqy lrygrdaqrc yceaancrgw 1501 iggepdsdeg eqldeesdsd aemdeeelea epeegqprks akakaksklk aklplatgrk 1561 rkeqtkpkdr eykagrwlkp satgssssae kppkkpkvnk fqamledpdv veelsllrrg 1621 glknqqdtlr fsrclvrakl lktrlallrv lthgelpcrr lfldyhglrl lhawisengn 1681 ddqlrealld tleslpipnr tmlsdsrvyq svqlwsnsle qqlavvpqek qaalhkrmva 1741 llqkwqalpe ifripkreri eqmkeherea drqqkhvhas taledqrere ssndrfrqdr 1801 frrdttssri gkpirmsgnn tictittqqk gsngapdgmt rndnrrrsdi gppseqrrtl 1861 skelrrslfe rkvaldeaer rvctedrleh elrceffgad intdpkqlpf yqktdtnewf 1921 nsddvpvpap prtelltkal lspdidvgqg atdveyklpp gvdplppawn wqvtsdgdiy 1981 yynlrerisq weppspeqrl qtlleenttq qplhelqidp avleneliqv dtdyvgslsa 2041 kslaqyieak vrerrdlrrs klvsirlisp rrdedrlynq lesrkykenk ekirrrkely 2101 rrrkievlpd avdeipvpgk alpiqpylfs sdeeetkvaa ieqpaaeeeq dslnmapsts 2161 haamaalgka vaqptglgtv gkrklpmpps vtvkkhrqeq rskkvkssqs pltatsarea 2221 hekfrfeisg hvanflrpyr kesctlgrit sdedykflvn rlsyhittke mrycevsgnp 2281 lsctesvkhk sydfinqymr qkgpvykkpa end