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LOCUS NP_001096869 3989 aa linear INV 26-DEC-2023 ACCESSION NP_001096869 VERSION NP_001096869.3 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 DBSOURCE REFSEQ: accession NM_001103399.4 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (residues 1 to 3989) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (residues 1 to 3989) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (residues 1 to 3989) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (residues 1 to 3989) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (residues 1 to 3989) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (residues 1 to 3989) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (residues 1 to 3989) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (residues 1 to 3989) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (residues 1 to 3989) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (residues 1 to 3989) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (residues 1 to 3989) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (residues 1 to 3989) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (residues 1 to 3989) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (residues 1 to 3989) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (residues 1 to 3989) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (residues 1 to 3989) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (residues 1 to 3989) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (residues 1 to 3989) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (residues 1 to 3989) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (residues 1 to 3989) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (residues 1 to 3989) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (residues 1 to 3989) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (residues 1 to 3989) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. The reference sequence is identical to ABW09330. On Jul 15, 2014 this sequence version replaced NP_001096869.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## Method: conceptual translation. FEATURES Location/Qualifiers source 1..3989 /organism="Drosophila melanogaster" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" Protein 1..3989 /product="terribly reduced optic lobes, isoform AZ" /name="CG33950 gene product from transcript CG33950-RAZ" /note="CG33950-PAZ; trol-PAZ; lethal (1) G0271; Trol/perlecan; mRNA-like ncRNA in embryogenesis 7; lethal (1) G0211; lethal (1) G0181; lethal (1) G0412; terribly reduced optic lobes; dPerlecan; lethal (1) G0023; lethal (1) G0374; lethal (1) G0019; lethal (1) G0021" /calculated_mol_wt=442065 Region 434..467 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(439,446,457..458) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(450,453,457,463..464) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 460..464 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 519..549 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(524,532,543..544) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(536,539,543,549) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 546..549 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 608..643 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(613,622,633..634) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(626,629,633,639..640) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 636..640 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 720..753 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(725,732,743..744) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(736,739,743,749..750) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 746..750 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 759..789 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(760,768,779..780) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(772,775,779,785..786) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 782..786 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 790..824 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(795,803,814..815) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(807,810,814,820..821) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 817..821 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 830..864 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(835,843,854..855) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(847,850,854,860..861) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 857..861 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 882..943 /region_name="Ig" /note="Immunoglobulin domain; cl11960" /db_xref="CDD:472250" Region 893..897 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 907..910 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 926..930 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 977..1011 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(982,990,1001..1002) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(994,997,1001,1007..1008) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1004..1008 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1017..1051 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1022,1030,1041..1042) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1034,1037,1041,1047..1048) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1044..1048 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1060..1094 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1065,1073,1084..1085) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1077,1080,1084,1090..1091) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1087..1091 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1112..1187 /region_name="Ig_Perlecan_like" /note="Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins; cd05743" /db_xref="CDD:143220" Region 1115..1121 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:143220" Region 1128..1133 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:143220" Region 1151..1155 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:143220" Region 1164..1170 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:143220" Region 1179..1185 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:143220" Region 1286..1416 /region_name="Laminin_B" /note="Laminin B (Domain IV); pfam00052" /db_xref="CDD:459652" Region 1473..1527 /region_name="EGF_Lam" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055" /db_xref="CDD:238012" Site order(1473,1475,1487,1497,1499,1508) /site_type="active" /note="EGF-like motif [active]" /db_xref="CDD:238012" Region 1651..1787 /region_name="Laminin_B" /note="Laminin B (Domain IV); pfam00052" /db_xref="CDD:459652" Region <1788..1814 /region_name="EGF_Lam" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055" /db_xref="CDD:238012" Region 1822..1871 /region_name="EGF_Lam" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055" /db_xref="CDD:238012" Site order(1823,1825,1832,1839,1842,1851) /site_type="active" /note="EGF-like motif [active]" /db_xref="CDD:238012" Region <1907..1937 /region_name="Laminin_EGF" /note="Laminin EGF domain; pfam00053" /db_xref="CDD:395007" Region 2003..2137 /region_name="Laminin_B" /note="Laminin B (Domain IV); pfam00052" /db_xref="CDD:459652" Region 2226..2294 /region_name="Ig_3" /note="Immunoglobulin domain; pfam13927" /db_xref="CDD:464046" Region 2319..2389 /region_name="Ig_3" /note="Immunoglobulin domain; pfam13927" /db_xref="CDD:464046" Region 2418..2486 /region_name="Ig_3" /note="Immunoglobulin domain; pfam13927" /db_xref="CDD:464046" Region 2515..2599 /region_name="Ig" /note="Immunoglobulin domain; cl11960" /db_xref="CDD:472250" Region 2532..2536 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:143259" Region 2545..2549 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:143259" Region 2564..2568 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:143259" Region 2578..2583 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:143259" Region 2591..2594 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:143259" Region 2617..2690 /region_name="I-set" /note="Immunoglobulin I-set domain; pfam07679" /db_xref="CDD:400151" Region 2622..2626 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 2635..2639 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 2656..2660 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 2670..2675 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 2683..2686 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:409353" Region 2693..2781 /region_name="Ig" /note="Immunoglobulin domain; cl11960" /db_xref="CDD:472250" Region 2713..2717 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 2726..2730 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 2747..2751 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 2761..2766 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 2774..2777 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:409353" Region 2826..2883 /region_name="Ig" /note="Immunoglobulin domain; cl11960" /db_xref="CDD:472250" Region 2829..2833 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 2841..2844 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 2861..2864 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 2909..2985 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 2918..2922 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 2931..2935 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 2965..2970 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 3003..>3064 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 3008..3012 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3019..3031 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3047..3051 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3113..3175 /region_name="Ig" /note="Immunoglobulin domain; cl11960" /db_xref="CDD:472250" Region 3125..3129 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3137..3142 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3158..3162 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3206..3272 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 3214..3218 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3227..3231 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3246..3250 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3260..3265 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 3274..3277 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:409353" Region 3294..3439 /region_name="LamG" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110" /db_xref="CDD:238058" Region 3462..3494 /region_name="EGF" /note="EGF-like domain; pfam00008" /db_xref="CDD:394967" Region 3542..3695 /region_name="LamG" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110" /db_xref="CDD:238058" Region 3754..3786 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Region 3795..3948 /region_name="LamG" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110" /db_xref="CDD:238058" CDS 1..3989 /gene="trol" /locus_tag="Dmel_CG33950" /gene_synonym="anon-WO0153538.72; BcDNA:GM02481; CG12497; CG33675; CG33950; CG7981; CT23996; Dmel\CG33950; EG:BACR25B3.1; EG:BACR25B3.10; EG:BACR25B3.11; EG:BACR25B3.2; GC7891; l(1)3Ac; l(1)9-96; l(1)G0019; l(1)G0021; l(1)G0023; l(1)G0181; l(1)G0211; l(1)G0271; l(1)G0374; l(1)G0412; l(1)trol; l(1)VA51; l(1)zw1; l(1)zwl; MRE7; pcan; Pcan; Pcn; Perl; Perlecan; Trol; TROL; Trol-A; Trol-B; troll; Troll; zw-1; ZW-1; zw1" /coded_by="NM_001103399.4:185..12154" /db_xref="FLYBASE:FBpp0309661" /db_xref="GeneID:45320" /db_xref="FLYBASE:FBgn0284408" ORIGIN 1 mmgspgsqas aiatsvgirs grrgqaggsl llrllavtfv laachapllt nakqisnlgd 61 dqdfmladde slqgindsew qlmgddiddg llddvdetlk pmetkseeed lptgnwfsqs 121 vhrvrrsinr lfgsddnqer grrqqrersq rnrdainrqk elrrrqkedh nrwkqmrmer 181 qlekqrlvkr tnhvvfnrat dprkrasdly deneasgyhe edttlyrtyf vvnepydney 241 rdresvqfqn lqklldddlr nffhsnyegn ddeeqeirst lerveielpt svndfgsklq 301 qqlnvynrie nlsaatdgvf sftessvtee svrhldvgfv ephitlfheq ntgyddfdrk 361 pttetqdiee eaidvtlpqe evegsgsdds scrgdatftc prsgkticde mrcdreiqcp 421 dgedeeycny pnvctedqfk cddkclelkk rcdgsidcld qtdeagcina pepepepepe 481 pepepesepe aepepepepe pesepeqepe pqvpeanecq anefrcnngd cidarkrcnn 541 vsdcsegede neeclegeee drvgipighq pwrpaskhdd wlhemdtsey qvyqpsnvye 601 kansqnpcas nqfrcttsnv ciplhlrcdg fyhcndmsde ksceqyqrht ttrrpltlat 661 ptsrittqgp gllerrnttt ateasrwpwa tktttiattt snpittvgva tttrlkpsdc 721 speqfycdes cynrsvrcng hvdcsdgsde vgcslpcpqh qcpsgrcyte sercdrhrhc 781 edgsdeancc yanqfrcnng dcvsgsapcn gysecsdhsd elncggtqec lpnqfrcnsg 841 qcvsssvrcn grtdcqdssd eqncaadsnd rrpnqlnlkt ypdsqiikes revifrcrde 901 gparakvkws rpggrplppg ftdrngrlei pnirvedagt yvceavgyas yipgqqvtvn 961 lnveryndvg srpesactey qatcmngeci dkssicdgnp dcsdasdeqs cslglkcqpn 1021 qfmcsnskcv drtwrcdgen dcgdnsdets cdpepsgapc rynefqcrsg hcipksfqcd 1081 nvpdctdgtd evgcmaplpi rpppqsvsll eyevleltcv atgtptptiv wrlnwghvpd 1141 kcesksyggt gtlrcpdmrp qdsgayscei intrgthfvn pdtivtvrpv rtdvceagff 1201 nmlarkaeec vqcfcfgvak acdsanlfty aihppilshr vvsvelsplr qivineaapg 1261 qdlltllhgv qfratnvhfs gretpylalp adymgnqlks yggnlryevn yrgsgrpvng 1321 pdviitgnrf tltyrvrtqp gqnnrvsipf vpggwqkpdg rkasreeimm ilanvdnili 1381 rlgyldstar evdliniald sagtadkglg saslvekcqc ppgyvgdsce scasgyvrqp 1441 ggpwlghcvp fipdscpsgt ygdprrgvpc kecpcpltgs nnfasgcqqs pdgdvvcrcn 1501 egytgrrceq caagyqgnpl aaggicrrip dtscnvdgty svhsngtcqc kdsvigeqcd 1561 tcksksfhln sftytgciec fcsgvgldcd sstwyrdqvt stfgrsrvdh gfvlvtnymq 1621 ptpdtvpvsm aaepnalsfi gsadqsgntl ywslpaaflg nklssyggkl tytlsysplp 1681 ngimsrnsap dvviksgedl rlihyrksqv vpsvantysv eikesawqrg devvanrehv 1741 lmalsditai yikatyttst keaslrqvtl dvatptnlgt praveveqcr cpegylglsc 1801 eqcapgyard peggiylglc rpcecnghsk ycnsdtgdce ecsdntegps cercaagyvg 1861 datrgtiydc qpdegypips ppapgnqtle ctaycqiegi ydcrgneclc krnvigdqcd 1921 qcrpgtygls aqnqdgckec ycsglasqcr saalyrqlip vdfilnapli tdesgavqdt 1981 enlipdisrn mytythtsyl pkywslrgsv lgnqlfsygg rlsyslives ygnyerghdi 2041 vlignglkli wsrpdgnenq eeynvrlhed eqwtrqdres arpasrsdfm tvlsdlqhil 2101 iratprvptq stsignvile savttrtpga thasdielcq cpsgyvgtsc escaplhyrd 2161 asgscslcpc dvsntescdl vsggyvecrc karwkgdrcr eidtndptdi gtedpvltqi 2221 ivsiqkpeit ivpvggsmtl scsgrmrwsn spvivnwyke nsrlpenvev qggnlylydl 2281 qvsdsgvyic qavnnetasv fkdtvsitit kkdqlspaei vnlpshvtfe eyvnneiice 2341 vlgnpaprvt warvdghada qstrtydnrl ifdsprksde gryrcqaend qnrdekyviv 2401 yvqsnppqpp pqqdrlyitp eeinglages fqlncqftsv aslrydwshn grslssspar 2461 nveirgntle vrdasesdsg vytcvaydvr trrnftesar vnidrreeqp fgnkpiiesl 2521 eqniliiqge dysitceasg spypsikwak vhdfmpenvh isgnvltiyg arfenrgvys 2581 cvaendhgsd lsstsidiep rerpsvkivs aplqtfsvga paslyctveg ipdptvewvr 2641 vdgqplsprh kiqspgymvi ddiqledsgd yecraknivg eatgvatitv qeptlvqiip 2701 dnrdlrlteg delsltcvgs gvpnpevewv nemalkrdly sppsntailk iyrvtkadag 2761 iytchgknea gsdeahvrve vqerrgdigg vdddsdrdpi nynppqqqnp gihqpgsnql 2821 latdigdnvt ltcdmfqpln trwervdgap lprnaytikn rleivrveqq nlgqyrcngi 2881 grdgnvktyf vkelvlmplp rirfypnipl tveagqnldv hcqvenvrpe dvhwstdnnr 2941 plpssvrivg svlrfvsitq aaageyrcsa fnqygnrsqi arvavkkpad fhqvpqsqlq 3001 rhregeniql qctvtdqygv raqdnvefnw frddrrplpn nartdsqilv ltnlrpedag 3061 ryicnsydvd rgqqlpevsi dlqvltatpp pnspiylppq lpaksrdysl klddqssnlr 3121 agestdvecy ssddtytdvv wersdgapls nnvrqvgnrl visnvspsda gnyvckcktd 3181 egdlyttsyk levedqphel ksskivyakv ganadlqcga desrqptyrw srqygqlqag 3241 rslmneklsl dsvqandagt yictaqyadg etadfpnilv vtgaipqfrq eprsymsfpt 3301 lpnssfkfnf eltfrpengd glllfngqtr gsgdyialsl kdryaefrfd fggkpmlvra 3361 eeplalnewh tvrvsrfkrd gyiqvdeqhp vafptlqqip qldliedlyi ggvpnwellp 3421 adavsqqvgf vgcisrltlq grtvelirea kykegitdcr pcaqgpcqnk gvclesqteq 3481 aytcicqpgw tgrdcaiegt qctpgvcgag rcentendme clcplnrsgd rcqyneilne 3541 hslnfkgnsf aaygtpkvtk vnitlsvrpa sledsvilyt aestlpsgdy lalvlrggha 3601 ellintaarl dpvvvrsaep lplnrwtrie irrrlgegil rvgdgperka kapgsdrils 3661 lkthlyvggy drstvkvnrd vnitkgfdgc isrlynfqkp vnlladikda aniqscgetn 3721 miggdedsdn eppvppptpd vhenelqpya mapcasdpce nggscseqed vavcscpfgf 3781 sgkhcqehlq lgfnasfrgd gyvelnrshf qpaleqsyts mgivfttnkp ngllfwwgqe 3841 ageeytgqdf iaaavvdgyv eysmrldgee avirnsdirv dngerhivia krdentaile 3901 vdrmlhsget rptskksmkl pgnvfvggap dlevftgfry khnlngcivv vegetvgqin 3961 lssaavngvn anvcpanddp lggteppvv