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Drosophila melanogaster Death-associated protein kinase related


LOCUS       NM_206688               4163 bp    mRNA    linear   INV 26-DEC-2023
            (Drak), transcript variant E, mRNA.
ACCESSION   NM_206688
VERSION     NM_206688.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4163)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4163)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4163)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4163)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4163)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4163)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4163)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4163)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4163)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4163)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4163)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4163)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4163)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4163)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4163)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4163)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4163)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4163)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4163)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4163)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4163)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4163)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4163)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_206688.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4163
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4163
                     /gene="Drak"
                     /locus_tag="Dmel_CG32666"
                     /gene_synonym="CG11713; CG1760; CG32666; Dmel\CG32666;
                     drak; DRak; EP(X)1452; EP1452"
                     /note="Death-associated protein kinase related"
                     /map="10C1-10C5"
                     /db_xref="FLYBASE:FBgn0052666"
                     /db_xref="GeneID:32097"
     CDS             48..2072
                     /gene="Drak"
                     /locus_tag="Dmel_CG32666"
                     /gene_synonym="CG11713; CG1760; CG32666; Dmel\CG32666;
                     drak; DRak; EP(X)1452; EP1452"
                     /EC_number="2.7.11.1"
                     /note="CG32666 gene product from transcript CG32666-RE;
                     CG32666-PE; Drak-PE"
                     /codon_start=1
                     /product="Death-associated protein kinase related, isoform
                     E"
                     /protein_id="NP_996411.2"
                     /db_xref="FLYBASE:FBpp0309256"
                     /db_xref="GeneID:32097"
                     /db_xref="FLYBASE:FBgn0052666"
                     /translation="MFTEKGIFPIGDGLLDVDADRLKGLLVSCPDINEIYEVEQTPFA
                     RGKFAAVRRAIHKNTGSHFAAKFLKRRRRAQSSDKEIKHEIAVLMLCEGEDNIVNLNA
                     VHETRSDTALLLELATGGELQTILDNEECLTEAQARHCMREVLKALKFLHDRSIAHLD
                     LKPQNILLAGERIEDGLKLCDFGISRVVCEGINVREMAGTPDYVAPEVLQYEPLSLLT
                     DIWSVGVLTYVLLSGFSPFGGDTKQETFLNISQCALTFPDNLFGGVSPVAIDFIRRAL
                     RIKPNDRMNATGCLDHIWLKDDCSLDRQIYLQPQSDAEEEEEEDVDDDVEDEEEEEQV
                     EEEEEETQNVEEPTTEAPQQQQQPVQQHQLAKSGQIHSKPTHNGHHRANSGGSISKIP
                     IATSKLQSTPSSETTTAIHTLTSNSNGHVHKPTQIVTPTRRASDSDKENTYTATFVKK
                     PVATIQLGSSNGIEDATVVATLTLFPDAPTTPKVIRKTPTGESNGSATSVKALVKKFQ
                     LEDSSGSAVARRSGGAVTSSSGLHSPTTTSVRLNSIRRASEPLTTVYKKQTSQNGCSS
                     TSNPSSSPGSSPTTSGSTATLLIHSQRLGNSTAPASHCVAVPATATATSSASSSNSSS
                     GKSTSAAHHLHHHHMHHHHHHHHHHVVIAAKNAAAVAATNNLSLDQGIIC"
     misc_feature    129..932
                     /gene="Drak"
                     /locus_tag="Dmel_CG32666"
                     /gene_synonym="CG11713; CG1760; CG32666; Dmel\CG32666;
                     drak; DRak; EP(X)1452; EP1452"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Death-associated protein kinase-Related Apoptosis-inducing
                     protein Kinase; Region: STKc_DRAK; cd14106"
                     /db_xref="CDD:271008"
     misc_feature    order(174..188,192..194,198..200,237..239,243..245,
                     339..341,387..392,396..398,408..410,414..416,525..527,
                     531..533,537..542,546..548,585..590,597..599,642..653)
                     /gene="Drak"
                     /locus_tag="Dmel_CG32666"
                     /gene_synonym="CG11713; CG1760; CG32666; Dmel\CG32666;
                     drak; DRak; EP(X)1452; EP1452"
                     /note="active site"
                     /db_xref="CDD:271008"
     misc_feature    order(174..188,192..194,198..200,237..239,243..245,
                     339..341,387..392,396..398,408..410,537..542,546..548,
                     585..590)
                     /gene="Drak"
                     /locus_tag="Dmel_CG32666"
                     /gene_synonym="CG11713; CG1760; CG32666; Dmel\CG32666;
                     drak; DRak; EP(X)1452; EP1452"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:271008"
     misc_feature    order(186..188,408..410,414..416,525..527,531..533,
                     537..539,597..599,642..653)
                     /gene="Drak"
                     /locus_tag="Dmel_CG32666"
                     /gene_synonym="CG11713; CG1760; CG32666; Dmel\CG32666;
                     drak; DRak; EP(X)1452; EP1452"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:271008"
     misc_feature    585..653
                     /gene="Drak"
                     /locus_tag="Dmel_CG32666"
                     /gene_synonym="CG11713; CG1760; CG32666; Dmel\CG32666;
                     drak; DRak; EP(X)1452; EP1452"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:271008"
     misc_feature    1182..>1709
                     /gene="Drak"
                     /locus_tag="Dmel_CG32666"
                     /gene_synonym="CG11713; CG1760; CG32666; Dmel\CG32666;
                     drak; DRak; EP(X)1452; EP1452"
                     /note="BDLF3; Provisional; Region: PHA03255"
                     /db_xref="CDD:165513"
ORIGIN      
        1 cactacacac acacaaacac cacaatcccc ccccacacac acacaaaatg ttcaccgaaa
       61 agggaatttt tcccattggc gacggacttt tggatgtgga cgccgatcgg ctgaagggac
      121 tcctcgtctc atgtcccgac atcaacgaga tctacgaagt ggaacagacg ccgtttgcca
      181 ggggcaaatt cgccgccgtt cgacgcgcca ttcacaagaa cacgggctcg cactttgcgg
      241 caaagttcct gaagcggagg cgccgggcgc agagtagcga caaggagatc aagcacgaga
      301 tcgcggtgct gatgctctgc gagggcgagg acaacatcgt caacctcaat gccgttcacg
      361 agacgcgctc ggacacagca ctcctcctcg agctagccac tggtggcgag ctgcagacga
      421 tcctggacaa cgaggagtgc ctgacggagg cgcaggcccg ccactgcatg cgcgaggtgc
      481 tcaaggcgct gaagttcctg cacgatcgct ccattgccca tttggacctc aagccgcaga
      541 acatcctgct cgccggcgag cgcatagaag atggattgaa gctgtgcgac tttgggatct
      601 cgcgggtggt gtgcgagggc atcaatgtgc gggaaatggc cggaacacca gactacgtgg
      661 cccccgaggt gctgcaatac gagccgctgt ccctgctgac ggacatctgg tcggtgggcg
      721 tgctcaccta cgtgctgcta tccggattct cgccctttgg cggcgacacc aaacaggaga
      781 ccttcctcaa catctcgcag tgcgccctca cctttccgga caacctcttc ggcggcgtct
      841 cgccggtggc catcgacttc atccgtcgcg cattgcgaat taagccaaac gatcgcatga
      901 atgccactgg ctgcttggat cacatttggt tgaaggacga ctgctcgctg gacagacaga
      961 tttatctgca gccccagagc gatgccgaag aggaggaaga ggaggatgtc gacgacgatg
     1021 tggaggacga ggaagaggag gagcaggtgg aggaggagga ggaggagaca cagaacgtgg
     1081 aggagccaac gacagaagcg ccacaacaac agcaacaacc tgtccagcag catcagctag
     1141 ccaaatccgg ccaaattcac agcaaaccga cgcacaatgg ccaccatcgg gcaaacagtg
     1201 gcggcagcat ctccaagata cccattgcga caagcaaact gcagagcact cccagctccg
     1261 agaccaccac ggccatccac acgctgacca gcaacagcaa tggacacgtc cacaagccca
     1321 ctcagattgt gacgccaacg cgaagagcct cggattcgga caaggagaac acgtatacgg
     1381 ccacgtttgt aaagaagcca gtcgccacca tccagctggg cagctccaat ggcatcgagg
     1441 atgccacggt tgtggccaca ctcactctgt ttcccgacgc acccaccaca ccaaaggtga
     1501 ttcgcaagac gccgacgggt gagtcgaatg gctcggcaac gtctgtcaag gctctggtga
     1561 agaaatttca actggaggac tcgagcggtt cggcggtggc acgacgcagt ggaggagcgg
     1621 tgaccagcag cagtggactg cattcgccaa cgacgacatc ggtcaggttg aatagcattc
     1681 gtcgcgcctc ggagccgctg accacggtct acaagaagca gacgtcacag aatggatgca
     1741 gcagcacttc gaatccgagc tcaagtcccg gcagcagtcc caccacatcc ggcagcaccg
     1801 ccactctgct gatccacagt cagcgtttgg gcaacagcac agcgccggcg agccactgcg
     1861 tcgccgttcc agcaacagcc acagccacct cctccgccag cagcagcaac agcagctcag
     1921 ggaagtcaac aagtgccgcc caccatttgc accatcatca tatgcaccac catcatcatc
     1981 accaccacca tcatgtggtg attgcggcaa agaatgccgc tgccgtggcc gccaccaaca
     2041 acttgagcct ggatcagggt atcatctgtt agctaagggc cagccgggcc agccgcaatg
     2101 ccaaaagttt ctttcatcgc tttctgtgct gcatgtaacc accagctgcc atggctacca
     2161 ctacgaccac taatacgaca ccacctcctc ccccgaccag cgcccactgg cagaaggcga
     2221 agaggagtgg ctgcgaatca cctagctgca ggatcactag gtggcaaagt ggcgatttga
     2281 ggagctatgg ctacggcaaa ggatcagcgt tgggaagccg gtggagttgg aacggaatag
     2341 gaaacgggaa cgggaactta aacttgaact ggaattggaa gtggagctgg aattggtgct
     2401 gcagcgggag atggaagtgg aagtggaagt ggagagggga tcatccgcca gactggcacg
     2461 aagacgatga tgcattgatt ttgatttgag cttagtttag ataatttttt tacggcctta
     2521 gcatctgaaa ggagtgccac actatatcac ggttgccaca tgagaacatc ttcttattca
     2581 acggaaaatt gaaagttttc atattcatac caaactttac agttttataa gttaaagaaa
     2641 tgtatgtttt tttttttaat atttgttaaa acgaatgttg tgttagacta cactattgga
     2701 ccttttcgat ggcaaccgtg cgttggcgac ccccaacata ccccccactc acacacacac
     2761 atacacaccc acacacacta gaaaaacgaa aaacaactta gctaaagtca cgagaaaaaa
     2821 aattaagcta aacgaaagga gatgaatgaa aaagattaag gaatcgagga gagcgttagg
     2881 tgtattagag tagagtaagc tgatttcaac ggaatttttg gtagacatat catccatgtt
     2941 tgttacgcgt tttgaggaaa acactagaag ctgctgaagg gaggggatag tgttcattgt
     3001 ttcaacgaat atataaatgt caatttttgg cccacaaggc atgcaagtaa gccctttggc
     3061 ctagcataaa ttatacaact aaatacatta tctatatata cacatatgca tacacatata
     3121 cactatacat agcatatata tgtaccaaaa agtgaagtga aacgacattt gagagccagc
     3181 ccgccattgg ttatgtagtg tgtttgttaa tcggccaatc agtgagtgca tcaatcagat
     3241 gataatcaat catatagcat agcatacagt gttattcgcc tagggggaat cagaatttag
     3301 agaatgttac cagccaagca aaattgttaa tcgtgtgtct cggtgtgtgt tcaatcgttc
     3361 aatcgttcaa atcgttgcat aaatgttgcc tagaatacat tacattactt gaaggaaggc
     3421 aggaagccgc atggatcata ttggaggaca tctagaggga cataactaat tgcttagccc
     3481 acataggcga cccatcgacc atctatccga tccttaaccc gattccgatt ccaatgccga
     3541 cccaaatcca catccagttt ccagttccca gctcccagct cccccagtcg tttgctcctc
     3601 gttttaagtc ggtttttgta tatatttcca gccagcagaa tgcaaaatgc agccagcagc
     3661 gaatataatt aaatgtaatt cttttttttt tcgataatca tatcttaatg cttgatatac
     3721 gagttgtatt tattaggcga aacgtttgtg tggtcggcga tcgaaggagg gtcagttaat
     3781 tgttaaagaa aaatgcttaa tttatcgtaa tcgattaccc ttttctttta tatttaatac
     3841 ttgcgtgtac ttctcttaat tactatgatt ttttttttta atacacctaa accacttatt
     3901 tgtgtttact gtatatgtaa attagtagtt aaaggcgagg gctttatgcc catcaacaga
     3961 taataaaaac tgcgccagag ggagcgagaa gtgtgtttta attattatta gtaattagta
     4021 atttcaattg attttttgtg tttagagaat ctatttctat gagaagacaa acaaagatgc
     4081 aaattctatt atatattata ttatatagta attattttat agataactaa tttaaaatat
     4141 attcaataaa aaccataaaa att