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Drosophila melanogaster alpha-Mannosidase class I a (alpha-Man-Ia),


LOCUS       NM_206675               3961 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant M, mRNA.
ACCESSION   NM_206675
VERSION     NM_206675.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3961)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3961)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3961)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3961)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3961)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3961)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3961)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3961)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3961)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3961)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3961)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3961)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3961)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3961)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3961)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3961)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3961)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3961)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3961)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3961)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3961)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3961)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3961)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_206675.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3961
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3961
                     /gene="alpha-Man-Ia"
                     /locus_tag="Dmel_CG42275"
                     /old_locus_tag="Dmel_CG32682"
                     /old_locus_tag="Dmel_CG32684"
                     /gene_synonym="a-Man-Ia; alpha-Man-1; alpha-Man-I;
                     alpha-Man-l; alpha-Man-la; alphaMan1a; CG17809; CG18799;
                     CG32682; CG32684; CG42275; DM-GI; dManI; dMas-1;
                     Dmel\CG42275; MA12; Man'ase; MAN-1; ManI; mas-1; mas1"
                     /note="alpha-Mannosidase class I a"
                     /map="9B5-9B7"
                     /db_xref="FLYBASE:FBgn0259170"
                     /db_xref="GeneID:31957"
     CDS             457..2460
                     /gene="alpha-Man-Ia"
                     /locus_tag="Dmel_CG42275"
                     /old_locus_tag="Dmel_CG32682"
                     /old_locus_tag="Dmel_CG32684"
                     /gene_synonym="a-Man-Ia; alpha-Man-1; alpha-Man-I;
                     alpha-Man-l; alpha-Man-la; alphaMan1a; CG17809; CG18799;
                     CG32682; CG32684; CG42275; DM-GI; dManI; dMas-1;
                     Dmel\CG42275; MA12; Man'ase; MAN-1; ManI; mas-1; mas1"
                     /EC_number="3.2.1.113"
                     /note="CG42275 gene product from transcript CG42275-RM;
                     CG42275-PM; alpha-Man-Ia-PM; alpha mannosidase I;
                     alpha-D-mannosidase; alpha 1,2 mannosidase; mannosidase 1;
                     alpha-1,2-mannosidase I; alpha1,2-,mannosidase;
                     alpha-mannosidase"
                     /codon_start=1
                     /product="alpha-Mannosidase class I a, isoform M"
                     /protein_id="NP_996398.1"
                     /db_xref="FLYBASE:FBpp0289741"
                     /db_xref="GeneID:31957"
                     /db_xref="FLYBASE:FBgn0259170"
                     /translation="MYRISPIGRKSNFHSREKCLIGLVLVTLCFLCFGGIFLLPDNFG
                     SDRVLRVYKHFRKAGPEIFIPAPPLAAHAPHRSEDPHFIGDRQRLEQKIRAELGDMLD
                     EPPAAGGGEPGQFQVLAQQAQAPAPVAALADQPLDQDEGHAAIPVLAAPVQGDNAASQ
                     ASSHPQSSAQQHNQQQPQLPLGGGGNDQAPDTLDATLEERRQKVKEMMEHAWHNYKLY
                     AWGKNELRPLSQRPHSASIFGSYDLGATIVDGLDTLYIMGLEKEYREGRDWIERKFSL
                     DNISAELSVFETNIRFVGGMLTLYAFTGDPLYKEKAQHVADKLLPAFQTPTGIPYALV
                     NTKTGVAKNYGWASGGSSILSEFGTLHLEFAYLSDITGNPLYRERVQTIRQVLKEIEK
                     PKGLYPNFLNPKTGKWGQLHMSLGALGDSYYEYLLKAWLQSGQTDEEAREMFDEAMLA
                     ILDKMVRTSPGGLTYVSDLKFDRLEHKMDHLACFSGGLFALGAATRQNDYTDKYMEVG
                     KGITNTCHESYIRAPTQLGPEAFRFSEAVEARALRSQEKYYILRPETFESYFVLWRLT
                     HDQKYRDWGWEAVLALEKHCRTAHGYCGLRNVYQQEPQKDDVQQSFFLAETLKYLYLL
                     FSDDSVLPLDEWVFNTEAHPLPIKGANAYYRQAPVTLPVSNAS"
     misc_feature    1048..2397
                     /gene="alpha-Man-Ia"
                     /locus_tag="Dmel_CG42275"
                     /old_locus_tag="Dmel_CG32682"
                     /old_locus_tag="Dmel_CG32684"
                     /gene_synonym="a-Man-Ia; alpha-Man-1; alpha-Man-I;
                     alpha-Man-l; alpha-Man-la; alphaMan1a; CG17809; CG18799;
                     CG32682; CG32684; CG42275; DM-GI; dManI; dMas-1;
                     Dmel\CG42275; MA12; Man'ase; MAN-1; ManI; mas-1; mas1"
                     /note="Cyclases involved in the biosynthesis of
                     lantibiotics, and similar proteins; Region: LanC_like;
                     cl04955"
                     /db_xref="CDD:471159"
ORIGIN      
        1 tggaaaaagc ggcgggcaca ttgtggatcg gatccaagct gtttttggtc gtctcgaact
       61 caaaaaaaga aacgtaaatc cagcggaatt aaacgcgatt gtggaaggcg tctcgttctt
      121 gtgatacctc tgccgtgaat cgatggtcgg tttgcggaaa ataataaggt ggcaggtgaa
      181 acgcgcattc ccctctctct cgcacaaaca cacctcctgc caggaacgga aagtaacaac
      241 aaaaacaact ggaagaagcg gctaaggtgg aagcgagata gaggcgacca taaataatct
      301 ttaaccgttt caccaaatca gagaaactga gaaaacataa acataactta aattaaaaag
      361 tccaccgcca atgcccgaga agactacagt gaaacaataa tacaaataac ccaaaacaat
      421 cagttaaatc gaattgaagc aaataaacaa tcgatcatgt atcgcatcag tccaattgga
      481 cgcaaatcga acttccactc gcgcgaaaaa tgtctgattg gactcgtcct ggtaacgttg
      541 tgcttcctct gcttcggcgg catcttcctt ctgccggaca atttcggcag cgatcgtgtc
      601 ctgcgcgtct acaagcactt ccgaaaggcc ggaccggaga tctttatccc agccccgccc
      661 ctcgccgcac acgcccccca tcgcagcgag gatccacatt tcattggcga tcgccaacgt
      721 ttggagcaaa agattcgcgc cgaattgggc gatatgctcg atgagccacc ggctgcgggt
      781 ggaggcgaac ctggacaatt ccaggtgctc gcccaacagg ctcaggctcc agcacccgtc
      841 gccgctctgg cggatcagcc gctggatcag gacgagggac acgccgccat tcccgttctg
      901 gccgccccag ttcaggggga caatgccgcc agccaggcct cgtcccatcc acaaagttcc
      961 gcccagcagc acaaccagca gcaaccacaa ctgccattgg gtggcggtgg caatgatcag
     1021 gcgccggaca cactggacgc cacactggaa gaacggcgtc agaaggtcaa agagatgatg
     1081 gaacatgcgt ggcacaatta caaattgtat gcgtggggca aaaacgagct gcgtccgctt
     1141 tcgcagcgac cccattcggc cagtattttt ggatcatacg atctgggtgc tacaatcgtc
     1201 gacggtctgg ataccctgta cattatggga ctggagaagg aatatcgcga gggtcgcgat
     1261 tggatcgagc gaaaattctc actggacaat atcagcgcag agttgagtgt tttcgaaacg
     1321 aacattcgtt ttgttggcgg catgctgacg ctgtacgcct ttacgggcga tccactgtac
     1381 aaggagaagg cccagcacgt tgccgacaag ctgctgcccg ccttccaaac accaacgggt
     1441 attccctacg cgctggtcaa caccaagacc ggtgtggcca agaactacgg ctgggcatcc
     1501 ggcggcagtt ctatcctatc cgaatttggc acactgcatc tggaatttgc ctatctgagc
     1561 gacattaccg ggaatccact gtatcgggaa cgagtccaga ccattcgcca agtgctcaag
     1621 gagatcgaga aaccaaaggg cctctatccc aacttcctta atcccaagac aggcaaatgg
     1681 gggcaacttc acatgtcatt gggcgctctg ggcgacagct actacgagta cttgctgaag
     1741 gcctggctgc aatccggcca aacggatgag gaagcccgcg agatgttcga cgaggcaatg
     1801 ctggccattc tggataagat ggtccgcaca agtcccggcg gactgacata cgtctctgat
     1861 ctcaagttcg acaggctgga gcataagatg gaccatttgg cttgcttctc gggtggcctc
     1921 ttcgctttgg gagcggctac acgtcaaaat gactatacgg acaagtacat ggaggtgggc
     1981 aagggcatta cgaatacctg ccacgagagc tacatcagag cacccactca gctgggaccc
     2041 gaggccttta gattcagcga agctgtggag gcgcgagcac tgagatcgca ggagaagtac
     2101 tacattctac ggccagagac tttcgagagc tactttgtgc tgtggcgact cacgcacgac
     2161 cagaaatacc gcgactgggg ctgggaggcg gtcctcgccc tggagaagca ctgccgcacg
     2221 gcgcacggat attgtggcct gcgcaacgtc taccagcagg agccgcaaaa ggacgacgtt
     2281 cagcaaagct tcttcctcgc cgaaacgctt aagtacctgt acttgctgtt ctcggacgat
     2341 tcggtgctgc cgctggacga atgggtgttc aacacggagg cccatccgct gccgatcaag
     2401 ggtgcgaatg cgtactatag acaggcgccc gtaacgcttc cggtttcgaa cgcatcgtaa
     2461 acgggcgcca tgttgcgccg ctggctattc ggcctgtccc tagcaatgca ccttacttag
     2521 ctcgcgatat ttggatatct acacatgtgt gtaccagatc gtaacatttt tttttttttt
     2581 tgttttgttt aagttattag ttagattacg tgaggatgac aactgcgtac gaaagatatt
     2641 gtatgtttac aatcaatcca ggcacacaca cacacacact cgagaaactg tcaatgtaac
     2701 atatttataa agcttgcaca tatataggaa cgtaaactta aacggatata tcgtagttta
     2761 gttcttaact gtttgcacaa gtttctccaa gtctctcttc ttgatttatc ttatggaatt
     2821 aatagcaatc caaatagttg acagaggtgg atggtgggaa gacctcaatt tccatttaaa
     2881 tgcgaatgac gtagacgtag gcaaaaactc ttgatattaa ttatgatatg atatataata
     2941 tgatatacgt gtaaatgtaa aactcaggtg ttcttattat gattttcctt gcgctcacac
     3001 aaggcacttt ttcaactaaa ccagctacgt aactatctct acaagcattc tatacgcaat
     3061 tctcgatctg cgactatatc tctgtgtgga tttatggcca cttggcgggc atttcgttag
     3121 atctactctg ctaatttcca attcgaatct ttgaccactt tattttgtat ataatttcta
     3181 ctgactttcc tcgcaaaatg aaggcagaag aaaatcgaat tgatatttat acaaatatat
     3241 tcttacacaa tattgtttac tttgtagcct aaatatttaa atataaatct aatatagagt
     3301 ctagcttact gtatgtgacg aaagaaatgt aacgcaaatt accttaaatc gagaacatca
     3361 agcgaaaaga acgcaaatga atatatataa agtaaaataa ataaatatat atttgtattt
     3421 aattaaatca aataaaacgt aggcaattgt taaaataaat taattatacg atggcacgag
     3481 ccgagcgaat ggtaatttaa tttttaacaa ctgtaaaggt tttttataat aataatacca
     3541 gcagtaatca tatttataat tctatttgtt cacacatgaa cacgaatata tttaaagact
     3601 tacaattttg ggctccgttc atatcttatg taaatgaatc gagagcgata aattatattt
     3661 aggattttgt tatctaaggc gacatgggtg cattgctcaa aaacatgtaa tttaagtgca
     3721 cactacatga gtcagtcact tgagatcgtt ccccgcctcc taaaatagtc ccttagtggg
     3781 agaccacaga taaggtcctc gccgctcaag ataggcagat gtgcccgagc gtgggacctc
     3841 gataaggcgg ggactattta cgtaggcctc tgcgtaggcc atttacttta agatgcgatt
     3901 ctcatgtcac ctatttaaac cgaagatatt tccaaataaa accagtttct tacaaaaact
     3961 c