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Drosophila melanogaster alpha-Mannosidase class I a (alpha-Man-Ia),


LOCUS       NM_206674               3853 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant N, mRNA.
ACCESSION   NM_206674
VERSION     NM_206674.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3853)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3853)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3853)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3853)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3853)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3853)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3853)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3853)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3853)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3853)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3853)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3853)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3853)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3853)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3853)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3853)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3853)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3853)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3853)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3853)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3853)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3853)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3853)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_206674.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3853
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3853
                     /gene="alpha-Man-Ia"
                     /locus_tag="Dmel_CG42275"
                     /old_locus_tag="Dmel_CG32682"
                     /old_locus_tag="Dmel_CG32684"
                     /gene_synonym="a-Man-Ia; alpha-Man-1; alpha-Man-I;
                     alpha-Man-l; alpha-Man-la; alphaMan1a; CG17809; CG18799;
                     CG32682; CG32684; CG42275; DM-GI; dManI; dMas-1;
                     Dmel\CG42275; MA12; Man'ase; MAN-1; ManI; mas-1; mas1"
                     /note="alpha-Mannosidase class I a"
                     /map="9B5-9B7"
                     /db_xref="FLYBASE:FBgn0259170"
                     /db_xref="GeneID:31957"
     CDS             349..2352
                     /gene="alpha-Man-Ia"
                     /locus_tag="Dmel_CG42275"
                     /old_locus_tag="Dmel_CG32682"
                     /old_locus_tag="Dmel_CG32684"
                     /gene_synonym="a-Man-Ia; alpha-Man-1; alpha-Man-I;
                     alpha-Man-l; alpha-Man-la; alphaMan1a; CG17809; CG18799;
                     CG32682; CG32684; CG42275; DM-GI; dManI; dMas-1;
                     Dmel\CG42275; MA12; Man'ase; MAN-1; ManI; mas-1; mas1"
                     /EC_number="3.2.1.113"
                     /note="CG42275 gene product from transcript CG42275-RN;
                     CG42275-PN; alpha-Man-Ia-PN; alpha mannosidase I;
                     alpha-D-mannosidase; alpha 1,2 mannosidase; mannosidase 1;
                     alpha-1,2-mannosidase I; alpha1,2-,mannosidase;
                     alpha-mannosidase"
                     /codon_start=1
                     /product="alpha-Mannosidase class I a, isoform N"
                     /protein_id="NP_996397.1"
                     /db_xref="FLYBASE:FBpp0289742"
                     /db_xref="GeneID:31957"
                     /db_xref="FLYBASE:FBgn0259170"
                     /translation="MYRISPIGRKSNFHSREKCLIGLVLVTLCFLCFGGIFLLPDNFG
                     SDRVLRVYKHFRKAGPEIFIPAPPLAAHAPHRSEDPHFIGDRQRLEQKIRAELGDMLD
                     EPPAAGGGEPGQFQVLAQQAQAPAPVAALADQPLDQDEGHAAIPVLAAPVQGDNAASQ
                     ASSHPQSSAQQHNQQQPQLPLGGGGNDQAPDTLDATLEERRQKVKEMMEHAWHNYKLY
                     AWGKNELRPLSQRPHSASIFGSYDLGATIVDGLDTLYIMGLEKEYREGRDWIERKFSL
                     DNISAELSVFETNIRFVGGMLTLYAFTGDPLYKEKAQHVADKLLPAFQTPTGIPYALV
                     NTKTGVAKNYGWASGGSSILSEFGTLHLEFAYLSDITGNPLYRERVQTIRQVLKEIEK
                     PKGLYPNFLNPKTGKWGQLHMSLGALGDSYYEYLLKAWLQSGQTDEEAREMFDEAMLA
                     ILDKMVRTSPGGLTYVSDLKFDRLEHKMDHLACFSGGLFALGAATRQNDYTDKYMEVG
                     KGITNTCHESYIRAPTQLGPEAFRFSEAVEARALRSQEKYYILRPETFESYFVLWRLT
                     HDQKYRDWGWEAVLALEKHCRTAHGYCGLRNVYQQEPQKDDVQQSFFLAETLKYLYLL
                     FSDDSVLPLDEWVFNTEAHPLPIKGANAYYRQAPVTLPVSNAS"
     misc_feature    940..2289
                     /gene="alpha-Man-Ia"
                     /locus_tag="Dmel_CG42275"
                     /old_locus_tag="Dmel_CG32682"
                     /old_locus_tag="Dmel_CG32684"
                     /gene_synonym="a-Man-Ia; alpha-Man-1; alpha-Man-I;
                     alpha-Man-l; alpha-Man-la; alphaMan1a; CG17809; CG18799;
                     CG32682; CG32684; CG42275; DM-GI; dManI; dMas-1;
                     Dmel\CG42275; MA12; Man'ase; MAN-1; ManI; mas-1; mas1"
                     /note="Cyclases involved in the biosynthesis of
                     lantibiotics, and similar proteins; Region: LanC_like;
                     cl04955"
                     /db_xref="CDD:471159"
ORIGIN      
        1 tggaaaaagc ggcgggcaca ttgtggatcg gatccaagct gtttttggtc gtctcgaact
       61 caaaaaaaga aacgtaaatc cagcggaatt aaacgcgatt gtggaaggcg tctcgttctt
      121 gtgatacctc tgccgtgaat cgatggtcgg tttgcggaaa ataataaggt ggcaggcgac
      181 cataaataat ctttaaccgt ttcaccaaat cagagaaact gagaaaacat aaacataact
      241 taaattaaaa agtccaccgc caatgcccga gaagactaca gtgaaacaat aatacaaata
      301 acccaaaaca atcagttaaa tcgaattgaa gcaaataaac aatcgatcat gtatcgcatc
      361 agtccaattg gacgcaaatc gaacttccac tcgcgcgaaa aatgtctgat tggactcgtc
      421 ctggtaacgt tgtgcttcct ctgcttcggc ggcatcttcc ttctgccgga caatttcggc
      481 agcgatcgtg tcctgcgcgt ctacaagcac ttccgaaagg ccggaccgga gatctttatc
      541 ccagccccgc ccctcgccgc acacgccccc catcgcagcg aggatccaca tttcattggc
      601 gatcgccaac gtttggagca aaagattcgc gccgaattgg gcgatatgct cgatgagcca
      661 ccggctgcgg gtggaggcga acctggacaa ttccaggtgc tcgcccaaca ggctcaggct
      721 ccagcacccg tcgccgctct ggcggatcag ccgctggatc aggacgaggg acacgccgcc
      781 attcccgttc tggccgcccc agttcagggg gacaatgccg ccagccaggc ctcgtcccat
      841 ccacaaagtt ccgcccagca gcacaaccag cagcaaccac aactgccatt gggtggcggt
      901 ggcaatgatc aggcgccgga cacactggac gccacactgg aagaacggcg tcagaaggtc
      961 aaagagatga tggaacatgc gtggcacaat tacaaattgt atgcgtgggg caaaaacgag
     1021 ctgcgtccgc tttcgcagcg accccattcg gccagtattt ttggatcata cgatctgggt
     1081 gctacaatcg tcgacggtct ggataccctg tacattatgg gactggagaa ggaatatcgc
     1141 gagggtcgcg attggatcga gcgaaaattc tcactggaca atatcagcgc agagttgagt
     1201 gttttcgaaa cgaacattcg ttttgttggc ggcatgctga cgctgtacgc ctttacgggc
     1261 gatccactgt acaaggagaa ggcccagcac gttgccgaca agctgctgcc cgccttccaa
     1321 acaccaacgg gtattcccta cgcgctggtc aacaccaaga ccggtgtggc caagaactac
     1381 ggctgggcat ccggcggcag ttctatccta tccgaatttg gcacactgca tctggaattt
     1441 gcctatctga gcgacattac cgggaatcca ctgtatcggg aacgagtcca gaccattcgc
     1501 caagtgctca aggagatcga gaaaccaaag ggcctctatc ccaacttcct taatcccaag
     1561 acaggcaaat gggggcaact tcacatgtca ttgggcgctc tgggcgacag ctactacgag
     1621 tacttgctga aggcctggct gcaatccggc caaacggatg aggaagcccg cgagatgttc
     1681 gacgaggcaa tgctggccat tctggataag atggtccgca caagtcccgg cggactgaca
     1741 tacgtctctg atctcaagtt cgacaggctg gagcataaga tggaccattt ggcttgcttc
     1801 tcgggtggcc tcttcgcttt gggagcggct acacgtcaaa atgactatac ggacaagtac
     1861 atggaggtgg gcaagggcat tacgaatacc tgccacgaga gctacatcag agcacccact
     1921 cagctgggac ccgaggcctt tagattcagc gaagctgtgg aggcgcgagc actgagatcg
     1981 caggagaagt actacattct acggccagag actttcgaga gctactttgt gctgtggcga
     2041 ctcacgcacg accagaaata ccgcgactgg ggctgggagg cggtcctcgc cctggagaag
     2101 cactgccgca cggcgcacgg atattgtggc ctgcgcaacg tctaccagca ggagccgcaa
     2161 aaggacgacg ttcagcaaag cttcttcctc gccgaaacgc ttaagtacct gtacttgctg
     2221 ttctcggacg attcggtgct gccgctggac gaatgggtgt tcaacacgga ggcccatccg
     2281 ctgccgatca agggtgcgaa tgcgtactat agacaggcgc ccgtaacgct tccggtttcg
     2341 aacgcatcgt aaacgggcgc catgttgcgc cgctggctat tcggcctgtc cctagcaatg
     2401 caccttactt agctcgcgat atttggatat ctacacatgt gtgtaccaga tcgtaacatt
     2461 tttttttttt tttgttttgt ttaagttatt agttagatta cgtgaggatg acaactgcgt
     2521 acgaaagata ttgtatgttt acaatcaatc caggcacaca cacacacaca ctcgagaaac
     2581 tgtcaatgta acatatttat aaagcttgca catatatagg aacgtaaact taaacggata
     2641 tatcgtagtt tagttcttaa ctgtttgcac aagtttctcc aagtctctct tcttgattta
     2701 tcttatggaa ttaatagcaa tccaaatagt tgacagaggt ggatggtggg aagacctcaa
     2761 tttccattta aatgcgaatg acgtagacgt aggcaaaaac tcttgatatt aattatgata
     2821 tgatatataa tatgatatac gtgtaaatgt aaaactcagg tgttcttatt atgattttcc
     2881 ttgcgctcac acaaggcact ttttcaacta aaccagctac gtaactatct ctacaagcat
     2941 tctatacgca attctcgatc tgcgactata tctctgtgtg gatttatggc cacttggcgg
     3001 gcatttcgtt agatctactc tgctaatttc caattcgaat ctttgaccac tttattttgt
     3061 atataatttc tactgacttt cctcgcaaaa tgaaggcaga agaaaatcga attgatattt
     3121 atacaaatat attcttacac aatattgttt actttgtagc ctaaatattt aaatataaat
     3181 ctaatataga gtctagctta ctgtatgtga cgaaagaaat gtaacgcaaa ttaccttaaa
     3241 tcgagaacat caagcgaaaa gaacgcaaat gaatatatat aaagtaaaat aaataaatat
     3301 atatttgtat ttaattaaat caaataaaac gtaggcaatt gttaaaataa attaattata
     3361 cgatggcacg agccgagcga atggtaattt aatttttaac aactgtaaag gttttttata
     3421 ataataatac cagcagtaat catatttata attctatttg ttcacacatg aacacgaata
     3481 tatttaaaga cttacaattt tgggctccgt tcatatctta tgtaaatgaa tcgagagcga
     3541 taaattatat ttaggatttt gttatctaag gcgacatggg tgcattgctc aaaaacatgt
     3601 aatttaagtg cacactacat gagtcagtca cttgagatcg ttccccgcct cctaaaatag
     3661 tcccttagtg ggagaccaca gataaggtcc tcgccgctca agataggcag atgtgcccga
     3721 gcgtgggacc tcgataaggc ggggactatt tacgtaggcc tctgcgtagg ccatttactt
     3781 taagatgcga ttctcatgtc acctatttaa accgaagata tttccaaata aaaccagttt
     3841 cttacaaaaa ctc