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Drosophila melanogaster topoisomerase related function 4-1,


LOCUS       NM_206659               4205 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant C (Trf4-1), mRNA.
ACCESSION   NM_206659
VERSION     NM_206659.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4205)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4205)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4205)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4205)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4205)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4205)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4205)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4205)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4205)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4205)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4205)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4205)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4205)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4205)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4205)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4205)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4205)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4205)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4205)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4205)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4205)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4205)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4205)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_206659.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4205
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4205
                     /gene="Trf4-1"
                     /locus_tag="Dmel_CG11265"
                     /gene_synonym="AAF46390; CG11265; Dmel\CG11265; DmTRF4-1;
                     dTrf4-1; Trf4"
                     /note="Topoisomerase related function 4-1"
                     /map="7F4-7F4"
                     /db_xref="FLYBASE:FBgn0030049"
                     /db_xref="GeneID:31795"
     CDS             518..3523
                     /gene="Trf4-1"
                     /locus_tag="Dmel_CG11265"
                     /gene_synonym="AAF46390; CG11265; Dmel\CG11265; DmTRF4-1;
                     dTrf4-1; Trf4"
                     /EC_number="2.7.7.-"
                     /EC_number="2.7.7.19"
                     /note="CG11265 gene product from transcript CG11265-RC;
                     CG11265-PC; Trf4-1-PC"
                     /codon_start=1
                     /product="topoisomerase related function 4-1, isoform C"
                     /protein_id="NP_996382.2"
                     /db_xref="FLYBASE:FBpp0071158"
                     /db_xref="GeneID:31795"
                     /db_xref="FLYBASE:FBgn0030049"
                     /translation="MDPFVGWFQKEQEGPSLCTWLKIWETNAQEMGALLNQQLQQATT
                     INGSTSSSSSSSNSGNNNNNNNNNIINNTITNTTNNTGNNSSAKPYLSRPYSSLNRVL
                     NFRADSLEILQQQQQQQQLNGTTQRNSTNINTTSGGSTSSSADSTTNRDNNSPANSSS
                     TNGPGAGTGTSTGAGGTGTNSPATTASSTAATTTGPATSMSDTSNNPPQSTTTPASRT
                     NSIYYNPSRKKRPENKAGGAHYYMNNHMEMIAKYKGEPWRKPDYPYGEGVIGLHEEIE
                     HFYQYVLPTPCEHAIRNEVVKRIEAVVHSIWPQAVVEIFGSFRTGLFLPTSDIDLVVL
                     GLWEKLPLRTLEFELVSRGIAEACTVRVLDKASVPIIKLTDRETQVKVDISFNMQSGV
                     QSAELIKKFKRDYPVLEKLVLVLKQFLLLRDLNEVFTGGISSYSLILMCISFLQMHPR
                     GIYHDTANLGVLLLEFFELYGRRFNYMKIGISIKNGGRYMPKDELQRDMVDGHRPSLL
                     CIEDPLTPGNDIGRSSYGVFQVQQAFKCAYRVLALAVSPLNLLGIDPRVNSILGRIIH
                     ITDDVIDYREWIRENFEHLVVVDRISPLPTAAPTAYATANGAPKYVIMPSGAVVQQLY
                     HHPVQVPTAHGHSHAHSHSHGHAHPGAHLCQPYVTGTTVSAVTTTTTMAVVTVGVSAG
                     GVQQQQQQQNATAHTHSQQQTQNQSQSRHRRGSTSSGDDSEDSKDGDVVETTSSAQEV
                     VDIALSTPNGLANMSMPMPVHAVGMPASNSWSGNGNGNGNSSSSTGSSPEIAHIAAQE
                     MDPELEDQQQQQQHQETSGGNGFIRPGDVGTGSNRGGGDGSGGRNYNQRNNHNSSGYY
                     HQQYYVPPPMQQQLSKSNSSSNYHQQHHHSHSHGNHSHRQQHHHQQQHHHQQRPQHLR
                     VGGGNRYQKSLGGSPIISAGNASNSSSNCSNSSSSSGSNNSRLPPLRGTLVNSSSAIS
                     IISISSESSIASSSSSSSRSGQDQQRDER"
     misc_feature    1328..>2266
                     /gene="Trf4-1"
                     /locus_tag="Dmel_CG11265"
                     /gene_synonym="AAF46390; CG11265; Dmel\CG11265; DmTRF4-1;
                     dTrf4-1; Trf4"
                     /note="DNA polymerase sigma [Replication, recombination
                     and repair]; Region: TRF4; COG5260"
                     /db_xref="CDD:227585"
ORIGIN      
        1 gtgcataaaa ggcatagagg cagcaaggag tgaaagagag agctccatcg gcagcgcaac
       61 gaaagtgagc gagaagcaga aattgttagt gcttataagg atatgtgaga agggagagtg
      121 agacagtaag aaagaacgga agaagcagca gcgacgccga ccgacaacaa ctgtaatttt
      181 ccattaattt ttgggcgggt tttgtgctgc acaataatac aactggcata atataacttg
      241 gcttattttt tataaccaac atgtgtattt tgttcacgtt ttgctgcgtg tgtaggtcac
      301 ttgaatgctg acagcattca aagaggttta gtcccggcag cgactttaat taatttttcc
      361 ctgtggagca caaagatcac atcggatcta tatagagtca cgtctatata ttcagaccac
      421 caggacgcag aggatagagg tgaaaggacg aagcgaagga gagacgcgcg cccccctcgt
      481 ttcccgccca gccaacagcc gtgtgaaccc gtcttgaatg gatccatttg ttggctggtt
      541 tcagaaggaa caggagggac catcgctgtg cacatggtta aagatttggg agacgaatgc
      601 ccaagagatg ggcgcattgc ttaatcaaca gctacagcag gcgacgacga tcaacgggag
      661 cacgagcagc agcagcagca gcagcaatag tggtaacaac aacaacaaca acaacaataa
      721 catcatcaat aacactatca ccaacacgac caataacact ggtaacaatt catcggccaa
      781 accctactta tcgcgaccct acagctcgct aaatcgggtg ctcaatttcc gagcggattc
      841 cctggagatc ctgcagcagc aacaacaaca gcagcagctc aacgggacca ctcagcgcaa
      901 cagcaccaac atcaatacca caagcggcgg cagcactagc tcgtcggcag attccaccac
      961 gaatcgggac aataactcac ccgccaatag cagttcaacc aacggacccg gagcaggaac
     1021 gggaacgtca acaggagcag gaggtaccgg tacaaatagt ccggcgacga cagcgtcaag
     1081 cacagctgcg accacgactg gtccagccac tagtatgagc gacaccagca acaacccgcc
     1141 acaatcaacg accacgcccg ccagccgcac gaacagcatc tactacaatc catcgcggaa
     1201 gaaacgaccg gagaacaagg ctggcggagc ccactactat atgaacaacc atatggagat
     1261 gatcgccaag tacaagggcg aaccgtggcg caagccggac tatccgtatg gcgagggcgt
     1321 tatcgggctg cacgaggaga tcgagcattt ctatcagtac gtcctgccca cgccctgcga
     1381 acacgccatc cgcaacgagg tggtcaagcg tatcgaggcc gttgtccatt ccatctggcc
     1441 acaggcagta gtcgagatct ttggctcctt tcgcactggc ctctttttgc ccacctccga
     1501 catagatctc gttgtgttag gtttgtggga gaagctgccg ctgagaacgc tggagttcga
     1561 gctagtgagc cgtggtatcg ccgaggcttg tacggtgcgt gttctggaca aggcatcagt
     1621 gcccatcatc aagctgacgg accgggaaac gcaagtgaag gtagacatat cgttcaacat
     1681 gcagagtggt gttcagtcgg cggagctgat taagaagttt aagcgcgact atccagtgct
     1741 ggagaagcta gtgcttgtgc tgaagcagtt cttactactt cgcgatctca acgaggtgtt
     1801 cacgggcggc atctcctcct actcgctgat ccttatgtgc atcagcttcc tgcagatgca
     1861 tccgcgcggt atctaccacg atacagccaa tctgggggtg cttctcctcg agttcttcga
     1921 actttatgga cgtcgcttca actacatgaa gatcggcatc tccataaaga acggtggccg
     1981 ctacatgccc aaggatgagc tgcagcgtga catggtcgat ggccatcgac cctcgctcct
     2041 gtgcatcgag gatccgctga cgccaggcaa tgatatcggt cgaagcagct acggcgtctt
     2101 ccaggtgcaa caggcattca agtgcgccta ccgcgtgctc gcccttgccg tcagtccgct
     2161 caaccttctc ggcatcgatc cgcgcgtcaa ctcgatactg ggtcgaatca ttcacatcac
     2221 cgacgacgtg atcgattatc gcgaatggat ccgcgagaac ttcgaacatc tggtggtggt
     2281 ggatcgtatc tcgccgctgc ccactgccgc tcccactgcg tacgccaccg ccaatggggc
     2341 gccaaaatat gtgattatgc cctcgggcgc cgttgtccag cagctgtacc atcatccggt
     2401 gcaggtgccc accgctcacg ggcacagcca tgcgcacagc cacagtcacg ggcacgcgca
     2461 tcctggcgcc catctgtgcc agccgtatgt gaccgggacc actgtatctg ctgtaacgac
     2521 gactacaacg atggcggtgg tgaccgtggg cgtgtcagcc ggcggagtcc aacagcagca
     2581 acagcaacag aatgcgacgg cccataccca ctcgcaacag cagacacaga accaatcgca
     2641 gtcgcgccat agacgcggca gcacctcgtc gggcgatgac tccgaggata gcaaggacgg
     2701 cgatgttgtc gagacgacgt cgagtgctca ggaggtcgtt gacatcgcgc tatcgacgcc
     2761 aaatggcctg gccaacatgt ccatgcccat gccagtgcat gctgtcggaa tgcctgcgtc
     2821 gaacagttgg agcggtaatg gcaatggaaa cggaaacagc agctcatcca cgggctcgtc
     2881 gccggaaatc gcacacatcg ctgcccagga aatggacccc gagcttgagg atcaacagca
     2941 acaacagcag caccaagaga cttctggagg taatggcttc atccgaccgg gtgacgtcgg
     3001 caccggttcc aacaggggag gcggtgacgg cagtggcggc cgcaattaca accagcggaa
     3061 caaccacaac tccagcggct actaccacca gcagtactac gtgccaccgc cgatgcaaca
     3121 gcagctgagc aagtccaact cctcctccaa ctatcaccag caacaccatc acagccacag
     3181 ccatggcaat catagtcacc gacaacagca tcaccaccag cagcagcacc accaccagca
     3241 gcggccgcag catctgcgtg tgggcggcgg caatcgatac cagaaatcgt tgggcggatc
     3301 gcccatcatc agtgctggca atgcgtcgaa cagcagcagt aattgcagca acagcagcag
     3361 cagcagcggc agcaacaaca gccgactgcc gccgctaagg ggcacgctgg tcaactcatc
     3421 gtcagcaata tcaatcattt ccatatcctc agaatcatcc attgctagca gcagctccag
     3481 ttcgtcaaga tccggtcagg atcagcagcg tgacgagcga taggaatagg atgtaggaag
     3541 atattgtgta tgtctatgac acagagagaa agagagtgcg acacagaggg acagagaatg
     3601 agagagaaag agatagttac ggtgttagca atatttatgg gttacatttc tttctcaggt
     3661 taattgtaaa ctacgctgca tttttctaat aaatatcatt gacccccccg cccccccgcc
     3721 tctacctaat ccgaaagcat ctcctcaacc aatgtaactg cgatcagatt ttcttttaca
     3781 ctgctgtctt gcttaaattg ggagagcgac gcagacctac taagcctagt gttaggaact
     3841 ttgcctctga tcgcgctaaa tgtatttcag tttgtttcta aaataaacat gaaagcaaag
     3901 aatatatata tatatatata tatatattta tatatataga tatatattaa attaaattaa
     3961 attgtaccat aagcataact gttagctcat aagtagattg taagggttta aaagatcgat
     4021 aaactgaagt atgaaattat gctaatctct tttcccatac cccccccccc ccctttttat
     4081 ccatcatcat gcgcattcaa gcttctaaag tattttgtag tttctgaaat gctctccgtc
     4141 tagtgcaatg gtaaacattt ttgcaaacgt aactaattcc ctatccaccc catttcctgc
     4201 catac