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Drosophila melanogaster topoisomerase related function 4-1,


LOCUS       NM_206658               4400 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant E (Trf4-1), mRNA.
ACCESSION   NM_206658
VERSION     NM_206658.4
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4400)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4400)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4400)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4400)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4400)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4400)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4400)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4400)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4400)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4400)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4400)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4400)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4400)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4400)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4400)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4400)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4400)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4400)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4400)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4400)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4400)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4400)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4400)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_206658.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4400
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4400
                     /gene="Trf4-1"
                     /locus_tag="Dmel_CG11265"
                     /gene_synonym="AAF46390; CG11265; Dmel\CG11265; DmTRF4-1;
                     dTrf4-1; Trf4"
                     /note="Topoisomerase related function 4-1"
                     /map="7F4-7F4"
                     /db_xref="FLYBASE:FBgn0030049"
                     /db_xref="GeneID:31795"
     CDS             713..3718
                     /gene="Trf4-1"
                     /locus_tag="Dmel_CG11265"
                     /gene_synonym="AAF46390; CG11265; Dmel\CG11265; DmTRF4-1;
                     dTrf4-1; Trf4"
                     /EC_number="2.7.7.-"
                     /EC_number="2.7.7.19"
                     /note="CG11265 gene product from transcript CG11265-RE;
                     CG11265-PE; Trf4-1-PE"
                     /codon_start=1
                     /product="topoisomerase related function 4-1, isoform E"
                     /protein_id="NP_996381.1"
                     /db_xref="FLYBASE:FBpp0071159"
                     /db_xref="GeneID:31795"
                     /db_xref="FLYBASE:FBgn0030049"
                     /translation="MDPFVGWFQKEQEGPSLCTWLKIWETNAQEMGALLNQQLQQATT
                     INGSTSSSSSSSNSGNNNNNNNNNIINNTITNTTNNTGNNSSAKPYLSRPYSSLNRVL
                     NFRADSLEILQQQQQQQQLNGTTQRNSTNINTTSGGSTSSSADSTTNRDNNSPANSSS
                     TNGPGAGTGTSTGAGGTGTNSPATTASSTAATTTGPATSMSDTSNNPPQSTTTPASRT
                     NSIYYNPSRKKRPENKAGGAHYYMNNHMEMIAKYKGEPWRKPDYPYGEGVIGLHEEIE
                     HFYQYVLPTPCEHAIRNEVVKRIEAVVHSIWPQAVVEIFGSFRTGLFLPTSDIDLVVL
                     GLWEKLPLRTLEFELVSRGIAEACTVRVLDKASVPIIKLTDRETQVKVDISFNMQSGV
                     QSAELIKKFKRDYPVLEKLVLVLKQFLLLRDLNEVFTGGISSYSLILMCISFLQMHPR
                     GIYHDTANLGVLLLEFFELYGRRFNYMKIGISIKNGGRYMPKDELQRDMVDGHRPSLL
                     CIEDPLTPGNDIGRSSYGVFQVQQAFKCAYRVLALAVSPLNLLGIDPRVNSILGRIIH
                     ITDDVIDYREWIRENFEHLVVVDRISPLPTAAPTAYATANGAPKYVIMPSGAVVQQLY
                     HHPVQVPTAHGHSHAHSHSHGHAHPGAHLCQPYVTGTTVSAVTTTTTMAVVTVGVSAG
                     GVQQQQQQQNATAHTHSQQQTQNQSQSRHRRGSTSSGDDSEDSKDGDVVETTSSAQEV
                     VDIALSTPNGLANMSMPMPVHAVGMPASNSWSGNGNGNGNSSSSTGSSPEIAHIAAQE
                     MDPELEDQQQQQQHQETSGGNGFIRPGDVGTGSNRGGGDGSGGRNYNQRNNHNSSGYY
                     HQQYYVPPPMQQQLSKSNSSSNYHQQHHHSHSHGNHSHRQQHHHQQQHHHQQRPQHLR
                     VGGGNRYQKSLGGSPIISAGNASNSSSNCSNSSSSSGSNNSRLPPLRGTLVNSSSAIS
                     IISISSESSIASSSSSSSRSGQDQQRDER"
     misc_feature    1523..>2461
                     /gene="Trf4-1"
                     /locus_tag="Dmel_CG11265"
                     /gene_synonym="AAF46390; CG11265; Dmel\CG11265; DmTRF4-1;
                     dTrf4-1; Trf4"
                     /note="DNA polymerase sigma [Replication, recombination
                     and repair]; Region: TRF4; COG5260"
                     /db_xref="CDD:227585"
ORIGIN      
        1 taaataatac taattgttta taataatcac aatgttttta acgaatttag ttggtgatgc
       61 gtcctgtcag ttgagtaggt gggaatagca tggactttcc ccaaataaca aatgctaagt
      121 tgggtttttt taaaattgat ttaatacatt ttttttatgt tacagttaaa tttgaaacta
      181 tatttaacaa gcaatttgga tgtcatcgat attttgtaat aggaccattc acttagcgga
      241 gtcatcaacc ttggcgaatc tagcgagcac atccacctct cgcttatcag gtctatcgat
      301 aacatcgctc atcaatcgat tcgtgaacca gctctatcgc gaaacggtcg cgtgttcgca
      361 cgcaaattgc aatataaatc cacagaaatt gacagggaac gttgctaaag ggcgaaaaac
      421 aatcgtgccg cgattgaggc ctgcgatctg cacaggaaat gcacaattgc gaagcgcaat
      481 ttgataaatt cgcacttgaa tgctgacagc attcaaagag gtttagtccc ggcagcgact
      541 ttaattaatt tttccctgtg gagcacaaag atcacatcgg atctatatag agtcacgtct
      601 atatattcag accaccagga cgcagaggat agaggtgaaa ggacgaagcg aaggagagac
      661 gcgcgccccc ctcgtttccc gcccagccaa cagccgtgtg aacccgtctt gaatggatcc
      721 atttgttggc tggtttcaga aggaacagga gggaccatcg ctgtgcacat ggttaaagat
      781 ttgggagacg aatgcccaag agatgggcgc attgcttaat caacagctac agcaggcgac
      841 gacgatcaac gggagcacga gcagcagcag cagcagcagc aatagtggta acaacaacaa
      901 caacaacaac aataacatca tcaataacac tatcaccaac acgaccaata acactggtaa
      961 caattcatcg gccaaaccct acttatcgcg accctacagc tcgctaaatc gggtgctcaa
     1021 tttccgagcg gattccctgg agatcctgca gcagcaacaa caacagcagc agctcaacgg
     1081 gaccactcag cgcaacagca ccaacatcaa taccacaagc ggcggcagca ctagctcgtc
     1141 ggcagattcc accacgaatc gggacaataa ctcacccgcc aatagcagtt caaccaacgg
     1201 acccggagca ggaacgggaa cgtcaacagg agcaggaggt accggtacaa atagtccggc
     1261 gacgacagcg tcaagcacag ctgcgaccac gactggtcca gccactagta tgagcgacac
     1321 cagcaacaac ccgccacaat caacgaccac gcccgccagc cgcacgaaca gcatctacta
     1381 caatccatcg cggaagaaac gaccggagaa caaggctggc ggagcccact actatatgaa
     1441 caaccatatg gagatgatcg ccaagtacaa gggcgaaccg tggcgcaagc cggactatcc
     1501 gtatggcgag ggcgttatcg ggctgcacga ggagatcgag catttctatc agtacgtcct
     1561 gcccacgccc tgcgaacacg ccatccgcaa cgaggtggtc aagcgtatcg aggccgttgt
     1621 ccattccatc tggccacagg cagtagtcga gatctttggc tcctttcgca ctggcctctt
     1681 tttgcccacc tccgacatag atctcgttgt gttaggtttg tgggagaagc tgccgctgag
     1741 aacgctggag ttcgagctag tgagccgtgg tatcgccgag gcttgtacgg tgcgtgttct
     1801 ggacaaggca tcagtgccca tcatcaagct gacggaccgg gaaacgcaag tgaaggtaga
     1861 catatcgttc aacatgcaga gtggtgttca gtcggcggag ctgattaaga agtttaagcg
     1921 cgactatcca gtgctggaga agctagtgct tgtgctgaag cagttcttac tacttcgcga
     1981 tctcaacgag gtgttcacgg gcggcatctc ctcctactcg ctgatcctta tgtgcatcag
     2041 cttcctgcag atgcatccgc gcggtatcta ccacgataca gccaatctgg gggtgcttct
     2101 cctcgagttc ttcgaacttt atggacgtcg cttcaactac atgaagatcg gcatctccat
     2161 aaagaacggt ggccgctaca tgcccaagga tgagctgcag cgtgacatgg tcgatggcca
     2221 tcgaccctcg ctcctgtgca tcgaggatcc gctgacgcca ggcaatgata tcggtcgaag
     2281 cagctacggc gtcttccagg tgcaacaggc attcaagtgc gcctaccgcg tgctcgccct
     2341 tgccgtcagt ccgctcaacc ttctcggcat cgatccgcgc gtcaactcga tactgggtcg
     2401 aatcattcac atcaccgacg acgtgatcga ttatcgcgaa tggatccgcg agaacttcga
     2461 acatctggtg gtggtggatc gtatctcgcc gctgcccact gccgctccca ctgcgtacgc
     2521 caccgccaat ggggcgccaa aatatgtgat tatgccctcg ggcgccgttg tccagcagct
     2581 gtaccatcat ccggtgcagg tgcccaccgc tcacgggcac agccatgcgc acagccacag
     2641 tcacgggcac gcgcatcctg gcgcccatct gtgccagccg tatgtgaccg ggaccactgt
     2701 atctgctgta acgacgacta caacgatggc ggtggtgacc gtgggcgtgt cagccggcgg
     2761 agtccaacag cagcaacagc aacagaatgc gacggcccat acccactcgc aacagcagac
     2821 acagaaccaa tcgcagtcgc gccatagacg cggcagcacc tcgtcgggcg atgactccga
     2881 ggatagcaag gacggcgatg ttgtcgagac gacgtcgagt gctcaggagg tcgttgacat
     2941 cgcgctatcg acgccaaatg gcctggccaa catgtccatg cccatgccag tgcatgctgt
     3001 cggaatgcct gcgtcgaaca gttggagcgg taatggcaat ggaaacggaa acagcagctc
     3061 atccacgggc tcgtcgccgg aaatcgcaca catcgctgcc caggaaatgg accccgagct
     3121 tgaggatcaa cagcaacaac agcagcacca agagacttct ggaggtaatg gcttcatccg
     3181 accgggtgac gtcggcaccg gttccaacag gggaggcggt gacggcagtg gcggccgcaa
     3241 ttacaaccag cggaacaacc acaactccag cggctactac caccagcagt actacgtgcc
     3301 accgccgatg caacagcagc tgagcaagtc caactcctcc tccaactatc accagcaaca
     3361 ccatcacagc cacagccatg gcaatcatag tcaccgacaa cagcatcacc accagcagca
     3421 gcaccaccac cagcagcggc cgcagcatct gcgtgtgggc ggcggcaatc gataccagaa
     3481 atcgttgggc ggatcgccca tcatcagtgc tggcaatgcg tcgaacagca gcagtaattg
     3541 cagcaacagc agcagcagca gcggcagcaa caacagccga ctgccgccgc taaggggcac
     3601 gctggtcaac tcatcgtcag caatatcaat catttccata tcctcagaat catccattgc
     3661 tagcagcagc tccagttcgt caagatccgg tcaggatcag cagcgtgacg agcgatagga
     3721 ataggatgta ggaagatatt gtgtatgtct atgacacaga gagaaagaga gtgcgacaca
     3781 gagggacaga gaatgagaga gaaagagata gttacggtgt tagcaatatt tatgggttac
     3841 atttctttct caggttaatt gtaaactacg ctgcattttt ctaataaata tcattgaccc
     3901 ccccgccccc ccgcctctac ctaatccgaa agcatctcct caaccaatgt aactgcgatc
     3961 agattttctt ttacactgct gtcttgctta aattgggaga gcgacgcaga cctactaagc
     4021 ctagtgttag gaactttgcc tctgatcgcg ctaaatgtat ttcagtttgt ttctaaaata
     4081 aacatgaaag caaagaatat atatatatat atatatatat atttatatat atagatatat
     4141 attaaattaa attaaattgt accataagca taactgttag ctcataagta gattgtaagg
     4201 gtttaaaaga tcgataaact gaagtatgaa attatgctaa tctcttttcc catacccccc
     4261 cccccccctt tttatccatc atcatgcgca ttcaagcttc taaagtattt tgtagtttct
     4321 gaaatgctct ccgtctagtg caatggtaaa catttttgca aacgtaacta attccctatc
     4381 caccccattt cctgccatac