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LOCUS NM_206654 10041 bp mRNA linear INV 26-DEC-2023 (Trf2), transcript variant H, mRNA. ACCESSION NM_206654 VERSION NM_206654.2 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 10041) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 10041) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 10041) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 10041) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 10041) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 10041) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 10041) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 10041) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 10041) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 10041) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 10041) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 10041) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 10041) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 10041) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 10041) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 10041) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 10041) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 10041) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 10041) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 10041) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 10041) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 10041) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 10041) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jan 16, 2013 this sequence version replaced NM_206654.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..10041 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..10041 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="TATA box binding protein-related factor 2" /map="7E7-7E9" /db_xref="FLYBASE:FBgn0261793" /db_xref="GeneID:31773" CDS 4307..6205 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="CG18009 gene product from transcript CG18009-RH; CG18009-PH; Trf2-PH; lethal (1) G0295; lethal (1) G0425; TBP-related factor 2; lethal (1) G0039; TBP related factor 2; lethal (1) G0071; TATA box-binding protein related factor 2; TBP-like factor" /codon_start=1 /product="TATA box binding protein-related factor 2, isoform H" /protein_id="NP_996377.1" /db_xref="FLYBASE:FBpp0303139" /db_xref="GeneID:31773" /db_xref="FLYBASE:FBgn0261793" /translation="MQNDMVSIPVANLNGGLKAASSGSGVGVVTSGGVVSSAVLANAP RVYLTPSSTFMTNRQMAGVASTGRMSGQVVGGSSGTASTAGTVRYFSQFSKMQTAGGP SLQRKLANGDTIVLATGSKNMFLTSSENKANLPTVASNGNGLITAKMDLLEEEVMQSI TVIDDDDEEKKEVAEDEEESSNNAKPIDLHQPIADNEHELDIVINNVVCSFSVGCHLK LREIALQGSNVEYRRENGMVTMKLRHPYTTASIWSSGRITCTGATSESMAKVAARRYA RCLGKLGFPTRFLNFRIVNVLGTCSMPWAIKIVNFSERHRENASYEPELHPGVTYKMR DPDPKATLKIFSTGSVTVTAASVNHVESAIQHIYPLVFDFRKQRSAEELQHLRQKQRL QAGGDPHELEKNVLADNKTASLDNIFVNTTAAHSKSSSNDQTSAPATILSSTVDSMPR LKQMVNYHQMMKQTQEERRHIMFNGEKANPASTSSAAAAPSTSSSSSSSGDNICANAR RRATECWATKLQNKRPRYNDPGTTGTINAASSTASAATSSLASQATHLRNPLKTAALA NARMLGAKVTTCTRNSIIVQQPQRIQMQQQQQQLQPQQQQTSFSPSEFDVDDLIEEEE NNELDMPF" misc_feature 4904..5425 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the...; Region: TLF; cd04517" /db_xref="CDD:239953" misc_feature order(4919..4924,4928..4930,5006..5011,5021..5023, 5027..5029,5048..5050,5054..5056,5066..5068,5072..5074, 5078..5080,5084..5086,5174..5176,5189..5191,5195..5197, 5282..5287,5300..5302,5339..5341,5345..5347,5351..5353, 5363..5365) /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="putative DNA interaction surface [nucleotide binding]; other site" /db_xref="CDD:239953" misc_feature order(4964..4966,4985..4993,4997..4999,5009..5011, 5027..5029,5033..5035) /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="putative TFIIA interaction surface [polypeptide binding]; other site" /db_xref="CDD:239953" misc_feature order(5225..5230,5264..5278,5285..5287,5300..5302) /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="putative TFIIB interaction surface [polypeptide binding]; other site" /db_xref="CDD:239953" ORIGIN 1 gctcaaagtg aaacggccaa acgaagaaga cgtatcgtgt gtgctcagac ttgtgctctc 61 aaaatttttg gtcaactaca ttattcagct ctgtttagag ttttaactaa aaaagatcac 121 aagccaaaaa aaaaaaaaac aaagagaaac ctaaagaaat atcaaccaaa agtgtgcaaa 181 atccaaaaga ttctacaatc cgaatcgaaa acaaaaacat aagaaccaca aaagcagcag 241 cagaaagaga cacagagagc agcgaaaact taactgcgaa ttcagcggct gaagcaaagc 301 agcggagccc aagtgcaagc gagacggcag cagagctccg ctgcaaggca acgggataga 361 aagagagata aatagagaga cagcgcagca gcgatataga gtgagagcag gcgggagagc 421 gagtagcggc agcgacagca acacagccac aaaagagatc gtgagaggga gggagagcta 481 gacgacgacc tactacacaa aaaaaggctc tgtggtcgcg attaccagcg tctacgacaa 541 gctagaaaac aaaaaaaaga aaaaatcatt caaataatta agactgctaa acggaacaac 601 taaaaactac aagcaaattt aaccaggaga aaagaacgga agactagaca taatcataaa 661 catagtagat agaattagag aaccagcaaa cccaacaact agaacactaa gaaaacatta 721 attctaatac aaaatcacac ataaaaaagt attttttggc cttaagtgca aacatactca 781 catacaaaca catacataca catccacatg aacgaaacaa tggaaagaat gtaatacaac 841 accaaggaag aatcaccttt agccttatat acaattaaat ataattaaga agctagcaag 901 aaaacgcaga gcaagagtcc tatcaagaaa cccaaaaaga taacaagaaa tattttttta 961 acgatgggca gtgcgtaagt aggcatacag agaaaaaaaa agaactatta cacgatatac 1021 agtagatata aagagccgca tatccacacc gccacagtca cacaaacacg tcaaaaaggg 1081 ggatggttcc ccgactcgaa tacttgaaga ataccaagta gctagagact taaggaacga 1141 ggatttgttt ccggaacatc cggttgaaca tccggacgaa gattcggata aggagaacca 1201 atcgccgaat caatccccca atccaagagc catcggtgat tgtgagcaag gacctgacat 1261 tggtaaagat actctaaatc ccaacgaagc tgaccagttt tcgagcgaag aagttgagaa 1321 gaacgaagcc aacagcagct gtaacgagtc gggcggggat gctcgcaatt ctagagatcg 1381 tttaagttcc tctcatagcg aggacgaaca gcttaaccaa gaatattcaa cttcatcaag 1441 cggaagcacc atcggaaatc gtgagcaagg ctctgacgtt ggtaaagata cttcaagtcg 1501 caacgaagct gaccagtttt cgaacgaaga agttgagaag aacgaagcca acagcagcgg 1561 taacgagtcg tacggggatg cctgcaattc tagtgatcgc ttaagttctt ctaatagcga 1621 ggacgaacag ctgcaccaag aatattcaac ttcatcaaga ggaagaacaa gggaatatgc 1681 acaatctgac ttgaatcccg ggtaccagga cttgaatatc ggtaaccagg acttgaatca 1741 agttaatcgc gagtaccagg agtctaataa cgagtaccag gtttcaaacc aagagtacca 1801 gcacttgaat accgagtacc aggagttgaa tcacggcgat caggactcaa atgacgagta 1861 ccaggagttg aatcacggca accaggactc aaatgacgag taccaggaat caaatcacgg 1921 caaccaggac tcaaatgacg agtaccagga gttgaatcac agcaaccagg actcaaatga 1981 cgagtaccag gagttgaatc acggcgatca ggactcaagt gacgagtacc aggatttgaa 2041 tcacgtcaac caagactcaa atcacgagta ccaggcttgg aatcacgaat accaggactc 2101 aaatcacgag tatcaggcct tgaatcgaga gtaccaatat cctgaatctg atgaggaaga 2161 ggccgctaga aaaagaaaca tatatacccg tttacgatcc tacgcttgtc aggtacatct 2221 ccctcgttta ggagaatcag aagttgatag cgacgatcgt cgccataacc caatcaatca 2281 gccattcaat cagccaatca ataggccaaa tcaaaaatcg gattcatctt tagagtcatc 2341 ttcgccggag agacaagact ctgaaagcga gtcgcgacaa gcttcagatg aggaatcgtc 2401 ttctggggac tcggactact taatcgatcc agttactggg tggctatcgc gccggcgaga 2461 aacttctacc gaacgcgagg aaaaaagcga ccaaagccaa caggagtcgt cagaggaaat 2521 tacagacgaa cagaaggaag aaagcgacga cgtcgaacaa cagtcgccgg ctgaacatac 2581 ttcttctgat agacgcgatc attcgccaga caagcaacag aataagcgaa aatcgttagg 2641 cactgggaat tcttcgtatt cgaagaaacc attattggac ggtgacaaag gagacccacg 2701 ttcacattta tcgtctctgg gaagtcgcag atccttaaag cgtaaatggc cttttgattg 2761 tacagactct aagaaattta aaccaaactt gcagagtgag gaagacaaat ctgaggagga 2821 aaaacgtgaa gatacggaaa gcgaatgctc tgacgaagaa gactcagata gttcaagttt 2881 cgatacagat tcaaattcag attcagattc aaatttagat ttagattccg attccgattc 2941 ccattccgat ttcgaatcat cttcaagttc tgaggaatct gcccaggatc cagctcctga 3001 aggcgaaacc gatcaagatc cagctcctga aggcgaagcc gatcaagatc cagctcctga 3061 aggcggagtc gatcaagatc cagctcctga aggcggagtc gatcaagatc cagctcctga 3121 aggcgaagtc gatcaagatc cagctcctga aggcgaatcc gatcaagatc tagctcctga 3181 aggcggagtc gatcaagatc cagctcctga attcggaacc gatcaagatc cacatcctta 3241 ttacaacgat caggatccag ctccttatta cgacgatcag gatccagctt cttattacga 3301 cgatcacatt tgtgattctg aggaggatta taaaccattt atcttctcaa aggaaaggaa 3361 gttcttgaaa ttcgtaacaa atcctttagg ggatgataaa tctagtttgg accttagcat 3421 acagctctat aaggtatttg gagcttacaa actggaagac gtatacagca gtattgatga 3481 ggaaggccaa ccagaacagg acctgcaact gaagcagcaa cagaaacatt taaaaaaata 3541 tcaaaagttg caactggtgg tattctggca ccaggagaaa ttcttttcaa aggagcaact 3601 gttgctatat gagtatctga aactactttt gcagaaattc tttccacaag agcaacagga 3661 gaaacggttg caacaggaga aacttttgca acaggagaaa ctcttgcaac aggagaaacg 3721 gttgcaacag gagaaacggt tgcaacagga gaaacggttg caacaggaga aacggttgca 3781 acaggagaaa cggttgcaac agcagaaact cttgcaacag cagaaactct tgcaacagga 3841 gaaactcttg caacagcaga aactcttgca acaggagaaa ctcttgcaac aggagaaact 3901 cttgcaacag gagaaacaat tgcaacagga gaaacacttg ccacaggagc gacagttgca 3961 acaggataaa gtcttcctac agctacgaca gttgcaacag aagaaagaac tggaggagca 4021 gcgagagcga aagcgccacc tctttgagca acagaaacag tttgtcctag aaaaattgcg 4081 ccaacagaag gagcagcatc gtcgtcagca aaatcgcgta aaacgcgaac gtaaattgcg 4141 ccagaaaaag gagaaacagc gcttggaata cgaacgattc ttgaaggaat atagggagga 4201 ctgtaaacgt cagttgcgtt tgcagcgcga gcattatctg atcaagatta agcagctgga 4261 gaaggccagt cagcgctcgt tgaaggggaa tcgaaagcac aagctgatgc aaaacgatat 4321 ggtcagcata ccggtggcca atttgaacgg cggccttaaa gcggccagca gcggttccgg 4381 agttggtgta gtgacctccg gcggcgtcgt atcctcggcg gtgctggcca atgccccacg 4441 tgtataccta acgccctcct ccacattcat gaccaatcgc caaatggcgg gagtggcgtc 4501 caccggaaga atgagcggac aagtcgtcgg tggttcatct ggcacagcct caacagccgg 4561 taccgttcgc tatttttcgc aattcagcaa aatgcaaacg gccggcggac ccagtttgca 4621 aaggaaactt gccaacgggg ataccattgt tctggcaacc ggcagtaaaa atatgttcct 4681 tactagcagc gaaaataagg ctaatctgcc gaccgtcgcc agcaatggca atggtctgat 4741 cacagccaaa atggatctat tggaggagga ggtcatgcag tcgataactg tgattgatga 4801 cgatgacgag gagaaaaagg aagtcgctga agacgaagaa gagagcagca ataatgccaa 4861 acccattgac cttcaccagc caattgctga taatgagcac gagctggaca ttgtgataaa 4921 caatgtggtc tgctcgttta gcgtcggctg tcacctgaag ctgcgcgaaa ttgcgctgca 4981 gggatcaaat gtggagtacc gtcgcgagaa cggaatggtg acaatgaagc tccgccatcc 5041 atacaccact gcctcgattt ggtcgtcggg gaggattacc tgcactggtg ccacttccga 5101 gtcaatggcc aaggtcgctg cacgccgcta tgccagatgc cttggcaagc tgggatttcc 5161 cactcgtttc ctcaactttc gcattgtcaa cgtactgggc acctgcagca tgccgtgggc 5221 catcaagatc gtcaactttt cggagcgcca tcgcgagaac gccagctacg agcccgagct 5281 gcatcctgga gtgacttaca agatgcgcga tcccgatcca aaggccaccc tgaagatctt 5341 ctccaccggc agcgtaacag tcaccgcggc tagcgtaaac cacgttgaat cggctatcca 5401 gcacatatac ccgctggtct ttgatttccg caagcaacgt tcggcggagg agctgcagca 5461 tctgcgtcaa aagcagcgtc tgcaagccgg cggtgatccc cacgaactgg agaaaaatgt 5521 cttggccgat aacaagactg cttcccttga taatatcttt gttaatacaa cagcggcgca 5581 ctctaaatca tcgtcgaatg accaaacatc agcacccgcg accatcttgt ccagcacagt 5641 tgatagtatg cctcgtctga aacagatggt caactatcac cagatgatga agcaaaccca 5701 ggaagagcgc cgccatataa tgtttaatgg ggagaaggcc aatccggcct ccacctcatc 5761 ggcggcagca gctccctcca cctcctcctc atcgtcctca tccggggata atatctgtgc 5821 caatgcccgt cgccgggcca ccgaatgctg ggcaaccaag ctgcagaata agcgtccacg 5881 ttacaatgat cccggtacca cgggcacaat taacgccgca tcgtccacag catcagccgc 5941 cacatcttcg ttagcctccc aggcgacaca tctgcgtaat cctctcaaga cggccgcgtt 6001 ggccaatgca cgtatgttag gcgccaaggt gacaacatgc acacgcaaca gcataatcgt 6061 gcagcagccg caacgtatcc aaatgcagca gcagcagcaa cagctgcaac cgcagcagca 6121 acagaccagc ttctcgccca gcgaattcga tgttgatgac ttgatcgagg aggaggagaa 6181 caacgaattg gatatgccct tctaagctag cgctgcccgt gccaaaaaaa aatttcaact 6241 aaaatggttc aaatcgatga tgaaacacta caacactaaa cacgccacac tcacaaatag 6301 ccacgagctt cttttcgaat ttgttggtta ttcgttcaag tcatttttca tcacatttat 6361 tttcgtgtgc ttgccgcatt taaactaaac tcgagaaagc ctggacaccg aagcgaaaag 6421 cacccacagc gaagcaacaa caacaaacaa caaacaaaac accgcagcaa caacaaaatc 6481 aagagccaaa tatttaaaat ataagattta cgtttaaact actttgtaag ttaagcgagc 6541 acaccagaaa caaacaagca gagatagcga atagatgatt tcgatcccga agtatcccag 6601 aaacctcaat aacatctaga tggtaagcaa gggagcttac cacacggtaa acataagttt 6661 agacttaaag aaaatacgta tgcgacagcg ttttacgtat ataaccgaaa tctgtggata 6721 gcctggatga gtcaccatca atcatcgcaa ttgcaatcaa ttgtggtgaa agtaagagaa 6781 cacacatgta gaactaatca ccaggacagg aagaggacga tacgagcaag gtgcccaggc 6841 ggatcggatc tcgcagcttc ctatcttatt ttaaattttt ttttgaagct gaactccaat 6901 tcagttctgg ccaagcaaac tacaattctc aagtaaaaat ccgtggagag gaggtggggc 6961 cagagaaaag cccactagga tagttatcaa ttatctgaag aacaactgat taatttcttg 7021 tatattcata ggaaattttt tttgttttcg ctataagtcc tacataataa atgctataca 7081 taagtgctgc gtgtgggcgc ataacaaacg aaacgaaatg cgtttgaatg cgattataat 7141 attaatatta ttatgcatat atacaacaca cacaaatacc tatatctggt cacttctaac 7201 caattataaa caaaactgga aaagcagaaa gtaattatgt atgttttaat ttgtgctggc 7261 agtttttgtg ttgcgcagaa actcgaatcg aattaagaat gaactcctgt aagatgatga 7321 caaaaataaa aaaaacattg taataggata gagggaagag gagtcgatta atgcgcgact 7381 tattaacaat aagctgaaac acatatatat atatatatat attgtaatgt tttttttttt 7441 tgtatttcgc ttaagtgtag atttacaaac ttgttcctgt gttgttaaaa tcagaaagta 7501 aatattttag ttaacttaac gaagcatacg catacacaaa cacactcaca cacacacaca 7561 cacatacgta tacatataca taatattaag gcatccaaac aaacaaccaa acaaacaaac 7621 aaacaaacga acgaacgaat cataagcaat aatagaatgt tttcgttgta aaagaggtaa 7681 aaataaaaac aaaaactaat gaaagaaata ctcacgttaa acataaaata acaaactcta 7741 gatgttttgg cgtgccttca cccataaata ggaaaacgaa atgagatacg atagccaatt 7801 gtacaatcat tgaagaaata gtacttccag accacaacag aacccaaaat cattgtacat 7861 acgcaaacaa aattgatgtt ttccaattaa acgtgaattg cctcattcgt acatcaagtt 7921 caattttcat ttgtgcttaa aaacatgaaa ccaactttca tatcgttcaa cttgtgcata 7981 atcaaaatag ctaaaacgaa agtaaaaggg aaattacata taattagtga gaaatatcaa 8041 acttttcttt ccctcgatta tttatacaca tttttggtat acaatttttt ttttgtttat 8101 tttttttttt ttaatgtttt aatttgcata aacaaaatcg agaaatgaaa atgcctttag 8161 ggaacaaata actagcgcgg aaaggaaaga gataggttta ggtataaaaa aaaaaaaaat 8221 gaaagatatt gaacagatcg gagccgaaat gtattttttg tgtatgcgaa tatgtgaata 8281 ggtcgacgat ggccgaagaa cgtgttacaa ttgcaaaatt aacttagcca ctaagcatta 8341 gtcttaagtt agctgacaaa ctgaatacta aattgtaagc cacaatgcat atagcaatgt 8401 aaaaaagaaa atgaaacaaa aaaaaaacaa acaacaaatc aaatctaatg gaacctaacg 8461 agaacattta agtgtaattt aagtgtaaat aaaatagttg ttaacaaatc acaaaacaaa 8521 cgaaagcaag aaaccaacaa tagtgtaatg tcttcacgtc taactgcctt cgaaagattc 8581 aagaattatt gaaatttaag caagcccaca ttttgaatgc gaagttagta ttctcttaaa 8641 acacgactgc aaattgcttc acttcaacct tgtactttca acacattttt ttttttttgt 8701 tagagcaaca acaacaacag caaccaacaa ttaacaatta acaattaaca gacggacgga 8761 gaactggaca aacggacaag ccgacaaacg gacagacaca acggacaaat agatcgaaaa 8821 gcctaaataa gtgtatttgg tttcaagaac tttgaaaaag caaaacttaa tattaatata 8881 gtatacagat atatttttga ttattatgta tttaatgaga aacaatgaaa cgattaatga 8941 taatgatgca agtatcgatg ataactaagt gaaaacaaat tgagaaatca aatagcataa 9001 ttctgttttt gttttgccgt aaagactgca ttataccaac aattaattat atacaaacat 9061 aataaataat taactgataa atggggcgag taagctttgc aactaagctg agaacaaaac 9121 ggatggataa acatttaaag caagcataca aaaaaagaaa aacaaacaaa aaaaaaaaga 9181 agaagcaaac catggaaaat aaaaccaaga aacatttatt tattagatcc taagtgaaga 9241 ctacgatttg ctagcggaga tcaagtcagg ccagagcgga ccttcaaggt accgcatcca 9301 agtacgaaaa gcaagatgaa attaccttac caaaatgtgc tagccctcga aaatccacca 9361 ttatctccat ggtggtaatc aaatgattat tcgcgagggc gagtctacaa gaaaaaagtc 9421 cataataggg cgagtaatcg gagtaattag taacactatc tatcgtatga taaatcaatt 9481 accaactaaa ctgggctaac aaaacacgta tatccactaa gatttatagt tttcccctaa 9541 tcccctgaaa ctaattctaa gtacataagt tgcaagcaaa acgctaagaa aaaaaaaaaa 9601 agaacctaaa agttagttat atacacacaa aagaggatat atgaatgagt gaatggcggt 9661 aagaaggaag gatgtgcgtt tactttggtt ttgagattgt ttgccgcagc ttcacatctc 9721 gagcgaaact gtgcggtttt tttgaaaacg tcagttttga aaaaaaaaaa ccagaactgg 9781 cgatttcaag caccgagcgt cgtttgtctt tcaatattta tcaaaaaaaa aacacacaca 9841 cacacaaata cacacagaaa gaactcattt gatgtattta gtttaacgtt tagccactag 9901 tttcgaggaa cgttaaaaaa tgcctttcct gaactgcagt caacactcaa ataagcgaca 9961 aacaaacaaa atgagaaaag aaaaaaagga aaccaaccaa ccaaatgaaa gcaaattgtt 10021 tgaataaaaa tcaaattaca t