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Drosophila melanogaster uncharacterized protein, transcript variant


LOCUS       NM_206649               5254 bp    mRNA    linear   INV 26-DEC-2023
            B (CG2258), mRNA.
ACCESSION   NM_206649
VERSION     NM_206649.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5254)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5254)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5254)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5254)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5254)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5254)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5254)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5254)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5254)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5254)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5254)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5254)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5254)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5254)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5254)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5254)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5254)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5254)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5254)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5254)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5254)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5254)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5254)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_206649.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5254
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5254
                     /gene="CG2258"
                     /locus_tag="Dmel_CG2258"
                     /gene_synonym="Dmel\CG2258"
                     /map="7D6-7D6"
                     /db_xref="FLYBASE:FBgn0029997"
                     /db_xref="GeneID:31729"
     CDS             456..2861
                     /gene="CG2258"
                     /locus_tag="Dmel_CG2258"
                     /gene_synonym="Dmel\CG2258"
                     /note="CG2258 gene product from transcript CG2258-RB;
                     CG2258-PB"
                     /codon_start=1
                     /product="uncharacterized protein, isoform B"
                     /protein_id="NP_996372.1"
                     /db_xref="FLYBASE:FBpp0071065"
                     /db_xref="GeneID:31729"
                     /db_xref="FLYBASE:FBgn0029997"
                     /translation="MLKALYDFQAVYPKTISFDEGEYFILYQTSARQRNWWQVVSMKG
                     NIGFVPSNYVMKIKVEHDFLISFLNSSIESLEKCTDHEINGIMSKDELLDRLREKKHT
                     MERLYAESSERDGDSSLSYSHSYSDKGSHRHSHPHPTQSQTQLHSQHRQHSPPPSGGS
                     VGSQRLDMSKKSMSSPAVGSSCGLPQNQGMIESPSMGSMQFQGSSCTIQTPQQQQPLP
                     APPAPAPSPSAASATPTAASTSKAATGGDVAQDNSITSEPSETTTTTTTTSEDVVTTY
                     KETSQMSTSQQHKPQNGSTASASISASASASALRSNGGNGKANGSATALHQELQQEEA
                     DSAPDKSDDASAVQSDDGCPANGDSADNSQALDSIDSPSHRQRGLSLGRIEEGATGGG
                     QLKVESSDVYQIVDALRRNTNLSFDLSCEALRVVLTSLEQLYNGAINPYLEAVAVHVT
                     GKVATPKELLGITHDAKRLQYLFAQLADCKNDTEQRTWMLYEDEEDIIQFLEELVEIL
                     INADESISCYEMSCDQYQMFINLVQYYQMETRWSIKRLLLKTFTAACHLDYIIVDILL
                     TSVLPLEIVEDMKTHFSNLDRFKQLVKMLTIIFSLGQPMPVNHQDYLGVHFASFLLEI
                     VEGNNPEVLVDMVIALILAFNQQFSEHTYNVIIEGMQNLPSAKVFTEKLLLLLNREDD
                     PTRLLKHPNEHMNTVLRMFIDIFSHPDTAGMFYTNDIKVLIDIVVRQLSDLDAGSTTR
                     PCYLELCRRILRNTNYQEHQHRKHDLMKIFTRIFCEETECSASDQQLVREIANEFPQL
                     FKA"
     misc_feature    456..620
                     /gene="CG2258"
                     /locus_tag="Dmel_CG2258"
                     /gene_synonym="Dmel\CG2258"
                     /note="Src homology 3 domain of SH3 protein interacting
                     with Nck, 90 kDa (SPIN90); Region: SH3_SPIN90; cd11849"
                     /db_xref="CDD:212783"
     misc_feature    order(471..473,477..479,486..488,498..500,558..563,
                     603..605,609..614)
                     /gene="CG2258"
                     /locus_tag="Dmel_CG2258"
                     /gene_synonym="Dmel\CG2258"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212783"
     misc_feature    2346..2753
                     /gene="CG2258"
                     /locus_tag="Dmel_CG2258"
                     /gene_synonym="Dmel\CG2258"
                     /note="SPIN90/Ldb17, leucine-rich domain; Region:
                     SPIN90_LRD; pfam09431"
                     /db_xref="CDD:462796"
ORIGIN      
        1 aaaggatcaa aagcgcaagg cgttgttgca ggacctaaaa gcagcgcaca aagcagaaac
       61 gggaaaggca ggaagagcga gcgagtgagc gagcgcaagt gaaatatgaa aattgcattt
      121 tcctcttcct gtgtgggggt gctccattaa aaattccacc agcacgagga gtatcctctt
      181 tgacggctcc gtgcgaatcc tgcggaactc agcagttcgc tgcagtccag tttagtggca
      241 cgaaaaaaca ttttggagca tcaataagag tgtagccagt gccgtcagtc cgcagtttgg
      301 ccctcggcag tgaacttaac tttttttttt agcgcctgct gcagtttttc cccgtgtgct
      361 tgtcagaggc agcggcagga ggtggccctg gtggaggagc aagtgttccc agtggaggag
      421 gtggcaacga catcggttta ggcatcggca tcgagatgct caaggctctg tacgacttcc
      481 aggcggtcta tccgaagacc atcagcttcg atgagggcga gtacttcatc ctttaccaga
      541 cgtccgcccg ccagcgcaat tggtggcagg ttgtcagcat gaaaggcaac attggctttg
      601 tgccctccaa ttacgtaatg aagattaagg tggagcacga ctttctcatc agctttctga
      661 actcctcgat agaatcgctg gagaagtgca cggaccatga gatcaatggc atcatgtcca
      721 aggacgaact gctggacagg ctgcgcgaga agaagcacac catggagcgt ctgtatgcgg
      781 agagttccga gcgcgacggt gactcctcgc tttcctattc acacagctac agtgacaagg
      841 gtagccaccg gcactcgcat ccccatccca cccaatccca gacgcagctt cattcccagc
      901 acaggcagca cagtccgccg cccagcggcg gcagcgttgg ctcccagcgt ttggacatga
      961 gcaagaagag catgtcaagt ccagcggtgg gctcatcgtg cggcctgccc cagaatcagg
     1021 gcatgatcga atcgcccagc atgggcagca tgcagttcca gggcagcagc tgcaccatcc
     1081 agacgccgca gcagcaacag ccgctcccag caccgccagc accagctccc tcgccatcgg
     1141 cagcatcggc cacacccact gcggcatcaa cgagcaaagc ggccaccggc ggtgatgtcg
     1201 cgcaggacaa tagcattacg tcggagccct cggagacgac aacgaccact acgacgacca
     1261 gcgaagatgt ggtcaccaca tacaaggaga ccagccaaat gagcaccagc cagcagcata
     1321 agccgcaaaa tgggagcact gcctcggcgt ccatttccgc atctgcctcg gcctcagctt
     1381 tgcgcagcaa cggcggcaac ggcaaggcca acggtagtgc cacagccctg catcaggagc
     1441 tgcagcagga ggaagcggac agtgcgccgg acaagtcgga tgatgccagc gccgtgcaaa
     1501 gtgacgacgg ttgcccggcc aacggagata gtgcggataa tagccaggcg ctggacagca
     1561 tcgacagtcc gtcgcatcga cagcgcggcc tgagcctggg cagaatcgag gagggtgcca
     1621 caggaggagg ccagttgaag gttgagtcat cggatgtata tcagattgtg gacgccctgc
     1681 ggcggaacac caacctcagc ttcgatctct cctgtgaagc attgcgcgtg gtgctgacca
     1741 gcctggagca gctgtacaac ggtgccatca atccgtacct ggaggcggtg gccgttcatg
     1801 tcactggcaa agtggccacg cccaaggagc tgctgggcat tacgcacgac gccaagcgct
     1861 tgcagtatct ctttgcccag ctggcggact gcaagaacga tacggagcaa cgcacttgga
     1921 tgctctacga ggatgaggag gacatcattc agttccttga ggagcttgtt gagattttga
     1981 tcaatgctga tgagagcatc agttgctacg agatgtcctg cgatcagtac cagatgttta
     2041 tcaatctggt gcagtactat cagatggaga cgcgctggtc catcaagcga ctgctgctta
     2101 agacctttac ggccgcttgc catctggact atatcattgt ggacatattg ctgacctcgg
     2161 tgctgccatt ggagattgtc gaggacatga agacgcactt ctccaatctg gatcgcttca
     2221 agcagctggt caagatgctc actattatct tctcacttgg acagcccatg ccggttaatc
     2281 atcaggatta tttgggcgta cattttgcca gcttcctact ggaaatcgtc gagggcaata
     2341 atccggaggt cttggtggac atggtcattg ccttgatctt ggccttcaat cagcaattta
     2401 gcgaacatac ctataatgtc atcatcgaag gtatgcagaa tctgccatcc gccaaagtgt
     2461 ttacggagaa gttgctactt ttgctcaatc gagaggatga tcccacacgc ttgctcaagc
     2521 atcccaacga gcatatgaac acggtgctgc gaatgtttat cgacatattc agccatccgg
     2581 atacggcggg catgttctac acgaatgaca tcaaggtgct tatcgatata gtggttcgcc
     2641 agctatccga tttggatgcc ggcagtacga cgcgaccatg ctacttggag ctttgccgac
     2701 gcatcctgcg caatacgaac tatcaggagc accagcatcg caagcatgat ctcatgaaga
     2761 tcttcacgcg catcttctgc gaggagaccg agtgcagtgc ctccgatcag cagctggtgc
     2821 gggaaatagc gaacgaattt ccgcagctgt tcaaggccta aggattattg gatacgtata
     2881 ccaaaacaac aacaaaagcc caaaccaaaa aaaaaaagaa caaaaaacac ggagggaaac
     2941 caaaattgta aagcgttgct agtgaggcga gccgttgaaa gcgagccaaa ccttaaaatc
     3001 tcaaataatt tcaagtttga tcagtgcatt tgttatgcgt ttgttttagc gtttcggtct
     3061 aggatagccc tcgtcaaaaa aaaaagtcaa atattgaaaa gaatgcattt cgatccatgc
     3121 cggatcgaaa gggagcacac acgcgactct acatatatct tatgaacata gtctgtaagc
     3181 aggacaaatg tactagttgc atgtggagta gatgcaacct catagagatg ataacccaat
     3241 ctagcgatct aggcgaaaga aatgaagcta tagcctatag cccatatagt ctaacactaa
     3301 attatcccct gtttaggatg atttcactaa tttagaattt agccagggac aattttagcc
     3361 agaagcagag tcagagatta gcctcacttt taaattttta tagttccaat tgcccatttg
     3421 tttggaattc aaaattttga caaaacaaaa gaagatggaa gcataagaaa gaatgaaatc
     3481 tttcgaggaa tataatattt atagcctaat tatacaccta taatgaaaat atacattcat
     3541 ggcgaatgcg aatgaaacgt taattgcaat ctacaagtaa acaattgata tattaacgat
     3601 gtatgatcgc agtatttgca gctagcaaaa tccaaatcga ttcgaatgta acgagcatat
     3661 aatgttaaat ttgtttatat aatctatgag atggagaact aagccgaaca ggaaatcatt
     3721 gacaattgtt aaagctcaaa tacttattaa ttggaggcta aggaggctgg aaattgaaaa
     3781 taattaacta tgcaagagca ttgaaagtta ggacaaccat ttgcatttct cactcactaa
     3841 aagacacgaa cacactgtgg cacttgcatt ttgaaggtat acagaattcc gaattatatt
     3901 aaaacaaatt attgcagtac cagttttatt tttttttgta atacttgtta ataccttttc
     3961 tttctgaact atagggtttt aacctccagc aaaccagcca cattttctct atatatctct
     4021 cactatttat caagaaaaaa taacaacaca aaattcccag cggatccaac gaaaagatcc
     4081 ataattttaa attttaattt taaggcaact ctattgtatt tgttatgtta tttagtagtt
     4141 agattcgaag aggcctagga cctctcaatc tagtttcaaa gcaggaatat tgtatttatt
     4201 tctgatagca cgatccgctg ggataagtta tatctatctc tatataaaca catacagcca
     4261 acaagataac aacataaaga gttttggaca gatttcaatg gcctatcttt gttattgtta
     4321 cgtcacagtt ataaatctta aaagttaaaa caacgaagct caaatgaaaa ttaacatttt
     4381 agaccagatt agtaatgaaa caaaattaga gggcggaaac cacatatgat atatattctt
     4441 cattggattt ggttacctta aacgtagtat agaaatcttg atatcattcc actttaaaaa
     4501 agcaataccc ttttaagttt tcaccccctt cagttaacga aaagtggttt agaaaacact
     4561 gcctatagct taggaaaaaa ttgaaaattc gcctcagcct gaattgaagt aaaagttaac
     4621 gtaattataa aattcaacat tttgccataa atttctattg tggtttcccc ccttaaaacc
     4681 attgcgatcc aatttgattt aagttttaga gattcccatt gttatattgt ttaagaaacc
     4741 aattttaatc aaaacgcatg agcataatat taaaagatct atttaaaaac ccctgtatgg
     4801 atctaatttt taaattaata ttaaaattga gacaagctgc gctgattcat gaacgaattt
     4861 aatttgccaa gtttcataac gaataggagt atttacaaac agttaaaaac taaactaaat
     4921 cagaaactaa aaccaatatt agccacgaat tgtacctttc gattttgaat ttaaataaca
     4981 ctctcggtat ttgcaagaaa aataaaagaa ataaataaaa acaataaggc aaagagtaaa
     5041 cgaagctgca ataaaaacaa ttgatgttta aaagtactac gttaacaaaa acaaacacgt
     5101 tttacgtcaa gcaaatagag ctaatttaaa agattgttat cctctcattt tttaacacga
     5161 aatagagatc ctaaatacag aaaaccaaac aaattacaag ttttaataaa cgcattcaaa
     5221 atgtaacgga acgaaattac aattgtaaga gatg