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LOCUS NM_206620 5537 bp mRNA linear INV 26-DEC-2023 variant E, mRNA. ACCESSION NM_206620 VERSION NM_206620.6 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 5537) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 5537) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 5537) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 5537) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 5537) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 5537) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 5537) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 5537) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 5537) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 5537) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 5537) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 5537) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 5537) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 5537) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 5537) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 5537) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 5537) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 5537) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 5537) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 5537) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 5537) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 5537) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 5537) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jan 26, 2009 this sequence version replaced NM_206620.5. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..5537 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..5537 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="Tousled-like kinase" /map="3E6-3F1" /db_xref="FLYBASE:FBgn0283657" /db_xref="GeneID:318206" CDS 197..3964 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /EC_number="2.7.11.1" /note="CG34412 gene product from transcript CG34412-RE; CG34412-PE; Tlk-PE; BEST:GH17330; tousled-like kinase; tousled like kinase" /codon_start=1 /product="Tousled-like kinase, isoform E" /protein_id="NP_996343.5" /db_xref="FLYBASE:FBpp0288854" /db_xref="GeneID:318206" /db_xref="FLYBASE:FBgn0283657" /translation="MPVVKQRKMSRFKMSPGAHLQMSPQNTSSLSQHHPHQQQQLQPP QQQQQHFPNHHSAQQQSQQQQQQEQQNPQQQAQQQQQILPHQHLQHLHKHPHQLQLHQ QQQQQLHQQQQQHFHQQSLQGLHQGSSNPDSNMSTGSSHSEKDVNDMLSGGAATPGAA AAAIQQQHPAFAPTLGMQQPPPPPPQHSNNGGEMGYLSAGTTTTTSVLTVGKPRTPAE RKRKRKMPPCATSADEAGSGGGSGGAGATVVNNSSLKGKSLAFRDMPKVNMSLNLGDR LGGSAGSGVGAGGAGSGGGGAGSGSGSGGGKSARLMLPVSDNKKINDYFNKQQTGVGV GVPGGAGGNTAGLRGSHTGGGSKSPSSAQQQQTAAQQQGSGVATGGSAGGSAGNQVQV QTSSAYALYPPASPQTQTSQQQQQQQPGSDFHYVNSSKAQQQQQRQQQQTSNQMVPPH VVVGLGGHPLSLASIQQQTPLSQQQQQQQQQQQQQQLGPPTTSTASVVPTHPHQLGSL GVVGMVGVGVGVGVGVNVGVGPPLPPPPPMAMPAAIITYSKATQTEVSLHELQEREAE HESGKVKLDEMTRLSDEQKSQIVGNQKTIDQHKCHIAKCIDVVKKLLKEKSSIEKKEA RQKCMQNRLRLGQFVTQRVGATFQENWTDGYAFQELSRRQEEITAEREEIDRQKKQLM KKRPAESGRKRNNNSNQNNQQQQQQQHQQQQQQQNSNSNDSTQLTSGVVTGPGSDRVS VSVDSGLGGNNAGAIGGGTVGGGVGGGGVGGGGVGGGGGRGLSRSNSTQANQAQLLHN GGGGSGGNVGNSGGVGDRLSDRGGGGGGIGGNDSGSCSDSGTFLKPDPVSGAYTAQEY YEYDEILKLRQNALKKEDADLQLEMEKLERERNLHIRELKRILNEDQSRFNNHPVLND RYLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANYIKHALREYNIH KALDHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQVVS ALKYLNEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNPDHGMDLT SQGAGTYWYLPPECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILE ENTILKATEVQFSNKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPIPKHGR GSLNQQQQAQQQQQQQQQQQQQQSSTSQANSTGQTSFSAHMFGNMNQSSSS" misc_feature <1841..>2251 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="Family of unknown function (DUF5401); Region: DUF5401; pfam17380" /db_xref="CDD:375164" misc_feature 2975..3778 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase; Region: STKc_TLK; cd13990" /db_xref="CDD:270892" misc_feature order(2984..2986,3023..3025,3029..3031,3137..3139, 3188..3199,3209..3211,3215..3217,3332..3334,3338..3340, 3344..3349,3353..3355,3395..3397,3404..3406,3473..3484) /gene="Tlk" /locus_tag="Dmel_CG34412" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="active site" /db_xref="CDD:270892" misc_feature order(3209..3211,3215..3217,3332..3334,3338..3340, 3344..3346,3404..3406,3473..3484) /gene="Tlk" /locus_tag="Dmel_CG34412" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:270892" misc_feature order(3392..3430,3443..3484) /gene="Tlk" /locus_tag="Dmel_CG34412" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="activation loop (A-loop); other site" /db_xref="CDD:270892" ORIGIN 1 tacaaattgt taagatcccc acataagtag taaataaagt aaagatcaca agttcgtgtt 61 aaataaatac attaaaatag ggaatccaag aaaagctgga atctcaaaat caaaagcaga 121 aagcacaaac caaaaaacaa acaaaaccag agaaagaaat aaaaagaggc ggcgagaaaa 181 ggaaagaaac aacgagatgc ctgtggtaaa acagcggaaa atgagccgct ttaagatgtc 241 ccccggcgcc catttgcaga tgtccccgca gaacacttcg tccctaagtc aacaccatcc 301 acatcaacag caacagttac aacccccaca gcagcaacaa cagcatttcc ctaaccatca 361 cagcgcccag caacagtcgc agcagcagca gcaacaggag caacagaatc cccagcagca 421 ggcgcaacag cagcagcaga tactcccaca tcaacatttg cagcacctgc acaagcatcc 481 gcatcagctg caactgcatc agcagcagca acaacaactc caccagcaac agcagcaaca 541 cttccaccag cagtcgctgc aagggctgca tcagggtagc agcaatccgg attcgaatat 601 gagcactggc tcctcgcata gcgagaagga tgtcaatgat atgctgagtg gcggtgcagc 661 aacgccagga gctgcagcag cagcgattca acagcaacat cccgcctttg cgcccacact 721 gggaatgcag caaccaccgc cgcccccacc tcaacactcc aataatggag gcgagatggg 781 ctacttgtcg gcaggcacga ccacgacgac gtcggtgtta acggtaggca agcctcggac 841 gccagcggag cggaaacgga agcgaaaaat gcctccatgt gccactagtg cggatgaggc 901 ggggagtggc ggtggctctg gcggagcagg agcaaccgtt gttaacaaca gcagcctgaa 961 gggcaaatca ttggcctttc gtgatatgcc caaggtaaac atgagcctga atctgggcga 1021 tcgtctggga ggatctgcag gaagcggagt aggagccggt ggcgccggaa gcgggggagg 1081 tggcgctggt tccggttctg gaagcggtgg cggcaaaagc gcccgcctga tgctgccagt 1141 cagcgacaac aagaagatca acgactattt caataagcag caaacgggcg tgggcgtcgg 1201 tgtgccaggt ggtgcgggag gcaataccgc tggccttcga ggatcacata cgggaggtgg 1261 cagcaagtca ccctcatccg cccagcagca gcaaacggcg gcacagcagc agggaagcgg 1321 tgttgcgacg ggaggcagtg caggcggttc cgctggcaac caggtgcaag tgcaaacgag 1381 cagcgcttac gccctttacc caccagctag tccccaaacc cagacgtcac agcaacagca 1441 gcagcagcaa ccgggatcag actttcacta tgtcaactcc agcaaggcgc agcaacaaca 1501 gcagcgtcaa cagcaacaga cttccaatca aatggttcct ccacacgtgg tcgttggcct 1561 tggtggtcat ccactgagcc tcgcgtccat tcagcagcag acgcccttat cccagcagca 1621 acagcagcaa caacagcagc agcaacagca gcaactggga ccaccgacca catcgacggc 1681 ctccgtcgtg ccaacgcatc cgcatcaact cggatccctg ggagttgttg ggatggtcgg 1741 tgtgggtgtt ggcgtgggcg ttggagtaaa tgtgggtgtg ggaccaccac tgccaccacc 1801 accgccgatg gccatgccag cggccattat cacttatagt aaggccactc aaacggaggt 1861 gtcgctgcat gaattgcagg agcgcgaagc ggagcacgaa tcgggcaagg tgaagctaga 1921 cgagatgaca cggctgtccg atgaacaaaa gtcccaaatt gttggcaacc agaagacgat 1981 tgaccagcac aagtgccaca tagccaagtg tattgatgtg gtcaagaagc tgttgaagga 2041 gaagagcagc atcgagaaga aggaggcgcg acagaagtgc atgcagaatc gcctcaggct 2101 cggacagttt gttacccaac gagtgggcgc cacattccag gagaactgga cggacggcta 2161 tgcgttccag gagctgagtc ggcggcaaga agaaataacc gctgagcgtg aagagataga 2221 tcggcagaaa aagcagctga tgaaaaagcg tccggcggag tccggacgca agcgcaacaa 2281 caacagtaac cagaacaacc agcagcagca gcaacagcaa caccagcaac agcagcagca 2341 acaaaattcc aactcgaacg attccacgca gctgacgagc ggagttgtta ccggtccagg 2401 cagtgatcgt gtgagcgtaa gcgtcgacag cggattgggt ggcaataatg cgggcgcgat 2461 cggtggcgga accgttggtg gtggcgttgg aggtggtggt gttggaggcg gtggtgtcgg 2521 aggcggcggt ggacgtggac tttctcgcag caattcgacg caggccaatc aggctcaatt 2581 gctgcacaac ggcggtggtg gttcgggcgg caatgtcggc aactcgggcg gcgttggcga 2641 ccgcttgtca gatcgaggag gaggaggtgg cggcatcggc ggaaacgata gcggcagctg 2701 ctcggactcg ggcactttcc tgaagccaga ccccgtatcg ggtgcctaca cagcgcagga 2761 gtattacgag tacgatgaga tcctcaagtt gcgacaaaat gccctcaaaa aggaggacgc 2821 cgacctgcag ctggagatgg agaagctgga gcgggagcgc aatctgcaca tccgagagct 2881 caagcggatt cttaacgagg atcagtcccg ctttaacaat catcccgtgc tgaatgatcg 2941 ctatcttctg ttgatgctcc tgggcaaggg cggcttctca gaggtccaca aggccttcga 3001 cctgaaggag caacgctatg tcgcatgtaa ggtgcaccaa ttaaacaagg attggaagga 3061 ggataagaaa gctaattata tcaaacacgc tttgcgggaa tacaacattc acaaggcact 3121 ggatcatccg cgggtcgtca agctatacga tgtcttcgag atcgatgcga attccttttg 3181 cacagtgctc gaatactgtg atggccacga tctggacttc tatttgaagc aacataagac 3241 tatacccgag cgtgaagcgc gctcgataat aatgcaggtt gtatctgcac tcaagtatct 3301 aaatgagatt aagcctccag ttatccacta cgatctgaag cccggcaaca ttctgcttac 3361 cgagggcaac gtctgcggcg agattaagat caccgacttc ggtctgtcaa aggtgatgga 3421 cgacgagaat tacaatcccg atcacggcat ggatctgacc tctcaggggg cgggaaccta 3481 ctggtatctg ccacccgagt gctttgtcgt gggcaaaaat ccgccgaaaa tctcctccaa 3541 agtggacgta tggagtgtgg gtgttatctt ctaccagtgt ctgtacggca aaaagccctt 3601 cggtcacaat cagtcgcagg ccacgattct cgaggagaat acgatcctga aggccaccga 3661 agtgcagttc tccaacaagc caaccgtttc taacgaggcc aagagtttca ttcggggatg 3721 cttggcctat cgcaaggagg atcgcatgga tgtgttcgca ctggccaggc acgagtacat 3781 tcagccaccg ataccgaaac atgggcgcgg ttcgctcaat cagcaacagc aggcgcaaca 3841 acagcagcag caacaacagc aacagcagca gcaacagtcg tcgacgtcac aggccaattc 3901 tacaggccag acatctttct ctgcccacat gtttggcaat atgaatcagt cgagttcgtc 3961 ctagctgcca accaagcgca attcgaactc ataattcgcc gccgccgcag tagcagcagc 4021 tacattagct gccagtagtc aacagcaact tcaacaccag caacagcaac tccaaatcca 4081 gcaataccag cagaatcagc aacttcattt gcaaaacagc agtagcaatt atgcggccac 4141 gcttctagat gcagcggcct tttgctacga aaccgtgatg gatgcagccc acttccaaaa 4201 caacaataat aacagcacca tcatcaagaa caatatgcag acaatgccgg caaacgctgc 4261 caatgctgct gcagctgcag ggggaggggg aacaccgacc tatcagggga aatacaagcg 4321 ctggcagcag caacagttac aacagcaggc gcaactccaa cagcagcagc acaagctgct 4381 gttgcagcaa gagctgctct aaaatatgaa gggaatgatg acaagcgagt ttaagagaac 4441 gaggagctgc ctgccacact gccgccgtca gcaataacaa catcccaaga aaattcacag 4501 cgagtcgcaa aagcatcaac aaacaaagca aaaaacgcaa aaaaggatta caaagacgca 4561 gagaataggg gacatttgca atgggaaata acaaattatt gcattatctg ctggattgtg 4621 attgtggttc aaacattaaa aatacactta ctcatacaca caaggtagac actgcagact 4681 aattttgcct taaaagaaac aaaacgaata atgttaactg taaattttca ctttgtgtcc 4741 atgcatagtt actagtaatg atgatataaa tatataaata tatataaaat ataaaaatta 4801 tataaatgta taaatttata tttatatata tatatatata tatatatata tatctgcata 4861 aacattgaag catactagta aatctttata aatatattta tatatatatt tatctcttcc 4921 ttttaacgct tttaatcgga aaaaacatcc caattatatt ttaattcaat ttgaaatata 4981 aaagtcattt ttgtttgttt tgtatcaaaa tccaaaaaaa attgatttaa atataaaaat 5041 accataaaca ttaacaccac acacacacac acacacacat atatatatat atatatatat 5101 atatatatat atacatatat atatacattt gtatatagtc gtatctgaac cacaaacaaa 5161 tccacagata aaaaaaactg aaaaattcat agaatcaaac cattttttta tatgccacaa 5221 agaaaagaaa ataagtagaa atgcaagaaa aatcgagaaa aagcgtaatt catgagatca 5281 gatcggatca gaaaaatcaa cagaaaataa acctatttga agtaaaatac ttctaaatac 5341 atagtaaact aatgtaatag tttttattaa aattacacat atatgtatcg atatatatac 5401 atgttttttt ttttttaatt ttaaaattat aattgtaatg cactatgcgt aaattgtatt 5461 aaatattaat atccaaggca tattaataga aatatatata catatataaa acctgcaaaa 5521 aaaaaacatg aactacc