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LOCUS NM_206596 5828 bp mRNA linear INV 26-DEC-2023 ACCESSION NM_206596 VERSION NM_206596.2 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 5828) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 5828) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 5828) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 5828) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 5828) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 5828) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 5828) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 5828) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 5828) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 5828) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 5828) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 5828) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 5828) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 5828) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 5828) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 5828) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 5828) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 5828) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 5828) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 5828) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 5828) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 5828) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 5828) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jul 15, 2014 this sequence version replaced NM_206596.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..5828 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..5828 /gene="svr" /locus_tag="Dmel_CG4122" /gene_synonym="cc; CG18503; CG32818; CG4122; CP; CPD; CpepE; CypD; Dmel\CG4122; dwp; EG:171D11.3; EP(X)0356; l(1)1Bd; poi; slv" /note="silver" /map="1B5-1B7" /db_xref="FLYBASE:FBgn0004648" /db_xref="GeneID:30998" CDS 475..4794 /gene="svr" /locus_tag="Dmel_CG4122" /gene_synonym="cc; CG18503; CG32818; CG4122; CP; CPD; CpepE; CypD; Dmel\CG4122; dwp; EG:171D11.3; EP(X)0356; l(1)1Bd; poi; slv" /EC_number="3.4.17.-" /note="CG4122 gene product from transcript CG4122-RG; CG4122-PG; svr-PG; carboxypeptidase E; pointed; DmSilver; chlorotic; carboxypeptidase D; silver; dwarp" /codon_start=1 /product="silver, isoform G" /protein_id="NP_996319.1" /db_xref="FLYBASE:FBpp0089126" /db_xref="GeneID:30998" /db_xref="FLYBASE:FBgn0004648" /translation="MPTLGLLFASIGIAVLAMGVPHCRGYTIKEDESFLQQPHYASQE QLEDLFAGLEKAYPNQAKVHFLGRSLEGRNLLALQISRNTRSRNLLTPPVKYIANMHG DETVGRQLLVYMAQYLLGNHERISDLGQLVNSTDIYLVPTMNPDGYALSQEGNCESLP NYVGRGNAANIDLNRDFPDRLEQSHVHQLRAQSRQPETAALVNWIVSKPFVLSANFHG GAVVASYPYDNSLAHNECCEESLTPDDRVFKQLAHTYSDNHPIMRKGNNCNDSFSGGI TNGAHWYELSGGMQDFNYAFSNCFELTIELSCCKYPAASTLPQEWQRNKASLLQLLRQ AHIGIKGLVTDASGFPIADANVYVAGLEEKPMRTSKRGEYWRLLTPGLYSVHASAFGY QTSAPQQVRVTNDNQEALRLDFKLAPVETNFDGNFRKVKVERSEPPQKLKKQFNGFLT PTKYEHHNFTAMESYLRAISSSYPSLTRLYSIGKSVQGRDLWVLEIFATPGSHVPGVP EFKYVANMHGNEVVGKELLLILTKYMLERYGNDDRITKLVNGTRMHFLYSMNPDGYEI SIEGDRTGGVGRANAHGIDLNRNFPDQYGTDRFNKVTEPEVAAVMNWTLSLPFVLSAN LHGGSLVANYPFDDNENDFNDPFMRLRNSSINGRKPNPTEDNALFKHLAGIYSNAHPT MYLGQPCELFQNEFFPDGITNGAQWYSVTGGMQDWNYVRAGCLELTIEMGCDKFPKAA ELSRYWEDHREPLLQFIEQVHCGIHGFVHSTIGTPIAGAVVRLDGANHSTYSQVFGDY WKLALPGRHNLTVLGDNYAPLRMEVEVPDVHPFEMRMDITLMPDDPQHWASANDFRII ENVVNTRYHTNPQVRARLAELENQNGQIASFGYADSEFGTIFNYLKMTSDIGEPEEHK YKLLVVSSLYDTTAPLGREILLNLIRHLVEGFKLQDTSVVELLKRSVIYFLPQTSKFQ NVFDMYNSNTSICDPVLGDELAERILGPETDQAKDVFLQFLRSERFDLMLTFGAGNSD LNYPKGDSVLVKFAHRMQRTEFNYSPLQCPPSATRQLHRETTERLTNMMYRIYNLPVY TLGISCCRMPHQKKIASVWRKNIDKIKNFLALVKTGVSGLVQNDKGQPLREAYVRLLE HDRIINVTKNVARFQLMLPHGLYGLEVTAPNYESQMIKVDVEDGRVTELGIIRMHPFT LIRGVVLELPNNDNRATTSIAGVVLDESNHPVRNAKVSVVGQTQLRNFTGSMGQYRIS AVPLGTITLKVEAPRHLEATRQMHLIQGGLATENVVFHLKVNEHVFGLPRFLFILCAS VLIIVGVIVCVLCAQFWFYRRHRGDKPYYNFSLLPQRGKEQFGLEDDDGGDDGETELF RSPIKRGMTIQPYFDEEQLERILHTDDDDDDGPHMEPELDVADDSEDDIVMLHNNGNK RRH" misc_feature 592..1476 /gene="svr" /locus_tag="Dmel_CG4122" /gene_synonym="cc; CG18503; CG32818; CG4122; CP; CPD; CpepE; CypD; Dmel\CG4122; dwp; EG:171D11.3; EP(X)0356; l(1)1Bd; poi; slv" /note="Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain I subgroup; Region: M14_CPD_I; cd03868" /db_xref="CDD:349440" misc_feature order(775..777,784..786,967..969,994..999,1123..1128, 1144..1146,1156..1158,1309..1311,1321..1323,1327..1329, 1387..1389) /gene="svr" /locus_tag="Dmel_CG4122" /gene_synonym="cc; CG18503; CG32818; CG4122; CP; CPD; CpepE; CypD; Dmel\CG4122; dwp; EG:171D11.3; EP(X)0356; l(1)1Bd; poi; slv" /note="active site" /db_xref="CDD:349440" misc_feature 1486..1722 /gene="svr" /locus_tag="Dmel_CG4122" /gene_synonym="cc; CG18503; CG32818; CG4122; CP; CPD; CpepE; CypD; Dmel\CG4122; dwp; EG:171D11.3; EP(X)0356; l(1)1Bd; poi; slv" /note="Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cd11308" /db_xref="CDD:200604" misc_feature 1840..2751 /gene="svr" /locus_tag="Dmel_CG4122" /gene_synonym="cc; CG18503; CG32818; CG4122; CP; CPD; CpepE; CypD; Dmel\CG4122; dwp; EG:171D11.3; EP(X)0356; l(1)1Bd; poi; slv" /note="Peptidase M14 carboxypeptidase subfamily N/E-like; Region: M14_CP_N-E_like; cd03858" /db_xref="CDD:349431" misc_feature order(2023..2025,2032..2034,2206..2208,2233..2238, 2350..2355,2371..2373,2383..2385,2584..2586,2596..2598, 2602..2604,2662..2664) /gene="svr" /locus_tag="Dmel_CG4122" /gene_synonym="cc; CG18503; CG32818; CG4122; CP; CPD; CpepE; CypD; Dmel\CG4122; dwp; EG:171D11.3; EP(X)0356; l(1)1Bd; poi; slv" /note="active site" /db_xref="CDD:349431" misc_feature 2761..2991 /gene="svr" /locus_tag="Dmel_CG4122" /gene_synonym="cc; CG18503; CG32818; CG4122; CP; CPD; CpepE; CypD; Dmel\CG4122; dwp; EG:171D11.3; EP(X)0356; l(1)1Bd; poi; slv" /note="Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cd11308" /db_xref="CDD:200604" misc_feature 3844..4044 /gene="svr" /locus_tag="Dmel_CG4122" /gene_synonym="cc; CG18503; CG32818; CG4122; CP; CPD; CpepE; CypD; Dmel\CG4122; dwp; EG:171D11.3; EP(X)0356; l(1)1Bd; poi; slv" /note="Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl21470" /db_xref="CDD:473874" misc_feature 4141..4377 /gene="svr" /locus_tag="Dmel_CG4122" /gene_synonym="cc; CG18503; CG32818; CG4122; CP; CPD; CpepE; CypD; Dmel\CG4122; dwp; EG:171D11.3; EP(X)0356; l(1)1Bd; poi; slv" /note="Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620" /db_xref="CDD:433354" ORIGIN 1 tccggacggg ttgcttctga cgtcacggcg tgggagtgga gctatcgatt tttgcgtaaa 61 aatatcctgt tgacgtccgt tctttcagct ctctccgctc tcttctgtct ctcactcaca 121 cacacaggcg caggcgccac acatattgag tctggcaact tccctctccg gggacgatac 181 tcttcaattt ccccactgtg cgcggcgact gaggcagcgg cagcggcggc ggcagaggcg 241 ggcgaatggg cgcttaaggc caatcaacgc agcaaatttt caaacagttg acttttcgag 301 cctgagctgc aacgacgacc cacgacgaac ggaggcccga cggacatata agaagagagc 361 gagttgtgtg cgggagagag ctgagaagaa gcggaggaaa aataactgtt tctcgctcaa 421 ttcgcacgcc agtgataaaa acaacataat ctcgacaaga ttgcaaatcg caagatgcca 481 actctgggtc tcctgttcgc ctccatcggc attgccgtgc tggcgatggg tgtgccgcat 541 tgcaggggct acaccatcaa ggaggacgaa tccttcctgc agcaaccgca ctatgctagc 601 caagagcagc tggaggacct gtttgctggc ctggagaagg cgtaccccaa tcaggccaaa 661 gtccacttcc ttggtcgatc tctagaagga cgaaatctgc tcgccctgca aatctcgcgg 721 aacacccggt cgcggaatct ccttacacct ccagtaaagt acatagccaa tatgcatgga 781 gacgaaacgg tgggcaggca gctccttgtt tatatggcac aatatctgct cggtaatcac 841 gaaagaatca gcgacctggg ccagctggtc aacagcaccg atatctactt ggtgcccacg 901 atgaatccag atggctatgc gttgtcccag gaaggcaact gcgagtcgct gcccaactat 961 gtgggtcgtg gcaatgcggc caacatcgat ttgaatcgcg atttccccga tcgcctggag 1021 cagagccatg tccaccagtt gcgcgcccag tctcgtcagc cggaaacagc agccctggta 1081 aattggatcg ttagcaaacc gtttgtgctc tccgccaatt tccatggcgg agctgttgtg 1141 gccagctatc cctatgacaa ctccttggct cacaatgagt gctgcgagga gagtttgact 1201 ccggatgatc gggtcttcaa gcagctggcc cacacctatt ctgacaacca tccgattatg 1261 agaaagggca acaattgcaa cgatagcttc tcgggaggta tcaccaacgg agcccactgg 1321 tatgagttgt ccggtggaat gcaggacttt aactatgcgt ttagcaactg tttcgagctg 1381 accatcgagt tgtcgtgctg caagtatccg gcagcaagca ctttgcccca ggaatggcag 1441 cggaacaagg catccctgct gcagctgctg cgccaggcac atatcggcat caagggcctg 1501 gtgaccgatg ccagtggctt tccaatagcc gatgccaatg tctacgtggc tggactagag 1561 gagaaaccca tgcgcacttc caaacgtggc gaatactgga ggcttttgac cccgggactc 1621 tatagcgtgc acgcctccgc ttttggttac cagaccagtg ccccgcaaca ggtccgggtg 1681 accaacgata accaggaggc cttgcgcctg gactttaagc ttgcgcccgt cgagacgaac 1741 tttgatggca acttccggaa agtaaaggtc gagcgctctg agcctccaca gaagctcaag 1801 aagcagttca atgggttctt gaccccgact aaatacgaac accacaactt tacggcaatg 1861 gagagctatc tgagggcgat tagcagcagc tatccttccc ttacacgcct ctacagcatc 1921 ggtaaaagcg tccagggtcg tgatctttgg gtgcttgaga tttttgccac gccgggttct 1981 catgtcccgg gggttccgga gttcaaatat gtggcaaaca tgcatggcaa cgaggtggtg 2041 ggcaaggaat tgcttctaat cctcaccaaa tatatgctgg aacgctatgg caatgatgac 2101 aggattacca agctggtgaa tggcacccgt atgcattttt tgtacagcat gaaccccgat 2161 gggtatgaga tctccatcga gggcgacaga accggcggag ttggaagagc gaatgcccat 2221 ggaattgatt tgaacagaaa cttccccgat caatatggca cggaccggtt caataaggtg 2281 acagagccag aggtggctgc cgtcatgaac tggacactgt cgctgccgtt tgttttgtcc 2341 gccaatctcc atgggggctc cttggtggcc aactacccct tcgacgataa cgaaaatgat 2401 tttaatgatc cgtttatgag actccgcaat tctagtatca atggccgcaa gccaaatccc 2461 accgaggata atgctctttt caaacacctc gccgggattt attcaaacgc acaccccact 2521 atgtacctgg gccagccatg tgagctcttc cagaatgaat tcttccctga tggcattacg 2581 aatggtgctc aatggtatag tgttactggg ggaatgcagg actggaacta tgtgcgggct 2641 ggatgcctgg agctaaccat cgaaatgggt tgcgataagt ttcccaaggc cgccgagctt 2701 tcgcgatact gggaggatca tcgcgagcct ctgctacagt ttatcgagca agtgcattgc 2761 ggcattcatg gatttgtgca tagcaccatt ggtacgccga ttgcgggagc tgttgttcgt 2821 ttggatggag ccaatcattc gacctacagt caagtcttcg gtgactattg gaagctagcg 2881 ctgcctggtc gacacaatct cactgtgttg ggggacaact atgcgccact acgaatggaa 2941 gttgaagtac ccgacgtcca ccccttcgaa atgcgaatgg atatcaccct catgccagac 3001 gatccccagc attgggcatc cgccaatgac tttaggatta ttgaaaacgt agtcaacaca 3061 aggtatcaca ctaaccctca agttcgcgca cgcctggcgg agctggagaa ccaaaatgga 3121 cagattgcca gctttggata tgccgattct gaatttggca caatcttcaa ttacctcaaa 3181 atgacatctg atattggcga gcccgaggaa cacaagtaca agctgttggt ggtcagttcc 3241 ctatacgata caacggctcc tctgggaagg gaaattttgc tcaacctgat acgacacttg 3301 gtcgaaggat ttaagctgca ggacacgtct gtagtcgagt tgcttaaacg aagtgttatc 3361 tacttcctgc cgcagactag caagttccaa aatgtctttg acatgtacaa cagcaacacc 3421 tccatttgcg acccagtcct gggggatgag ttagcagagc gcattcttgg cccggagaca 3481 gaccaggcca aggacgtatt cctgcaattt ttgcgtagcg aacgctttga tttgatgctt 3541 acctttggag caggcaactc cgacttgaac tatccgaaag gggactcggt gctagtgaag 3601 tttgcccaca gaatgcagcg aacggagttc aactactcgc ccctgcagtg ccctccatcg 3661 gccacgagac agctccaccg ggagaccacc gagagattga ccaatatgat gtaccgcata 3721 tacaatttgc ccgtttacac cttgggcatt tcctgctgcc gcatgccgca ccaaaagaaa 3781 atcgcttccg tttggcgcaa aaacatcgat aagattaaga actttttggc tctagtgaaa 3841 accggagtaa gtggcttggt gcagaacgat aaaggacaac cattgaggga ggcctatgtc 3901 cgattgttgg agcacgatag aatcattaat gttaccaaga atgtggcgag attccagttg 3961 atgctgcccc atggtcttta tggcttggag gtaactgctc ccaactacga gtcgcaaatg 4021 attaaggtgg acgtagaaga tggtcgagtc acggaattgg gcattatacg catgcatcca 4081 ttcacgttga ttcgtggcgt tgtcctggag ctgccaaata acgataacag agccaccact 4141 agcattgcag gagtggtgct ggatgagagc aaccacccag tgcggaacgc caaggtctcg 4201 gtggtggggc agactcaatt gagaaacttt acaggcagca tgggacagta tcgtatatcg 4261 gcggtaccct taggcaccat cactctaaaa gtagaggcac cgcggcatct ggaggccacc 4321 cgacaaatgc acctgattca gggcggcttg gccacagaga acgtggtctt tcacctaaaa 4381 gttaacgagc atgtctttgg attgcctcgc tttttgttca ttttgtgcgc cagcgttctg 4441 atcattgttg gtgtcatcgt ctgtgtgcta tgtgcccagt tttggttcta tcgacgccat 4501 cggggggata agccttatta taacttctca ctgctgccgc agaggggtaa ggagcagttt 4561 ggccttgagg acgatgatgg gggtgatgat ggggaaacgg agctctttcg atctcccatc 4621 aaacgcggca tgaccataca gccgtacttt gatgaggagc agctggagcg gatcctgcac 4681 acggatgacg atgacgacga cggaccgcac atggagccag aacttgatgt ggctgacgat 4741 agcgaagacg acatagtgat gttgcataac aacgggaaca agagacggca ctagatgttc 4801 tgatagatgt tcccaatcaa acacaatctc gagtgacaca accaccaggg atcacctaat 4861 ccccgatcga ctttaaccac acacaacata actgtgattc aaaacgtttt caagagaaac 4921 caacgctctc cttttttgtt atttttgtgt aatatctacc cttaaaaggt gaaacacttt 4981 atttttgagt tttagtgtta ctgagcttgc acctagaatg catcacaatc gtcagcttta 5041 aatagaaaat cctactaccc actcggcaaa tctctcgttc atgaccgttt atatagagat 5101 atacattttt atgttcagcc aaaagaactg tatgcgtaaa tgtaacttaa actaaagact 5161 gagagcctca taattctagc aaaaaaaaaa ccataacaat ttgtgaaaaa atattaaatc 5221 taatctagct aaaaagaaac cgaaaatcac agccaacaac agcagaagat tgagtttgtt 5281 ttaatgaaaa aattaactaa caatgaatca aaaacaatgt caatattaaa ttatactaat 5341 ttattaagca ttgtcttcag aaagctaaat tacttagcag ctcattatac agaaaattga 5401 ttcttaaaga ttaattttaa gcttactgtt ttacaattta ttaaaccata tttagtagct 5461 tttatcggaa attgaatggt tactcccatg aactctaacc ctctgtatgc tgaaatcagg 5521 ctttctaaaa atgattttaa atgctggaaa aaaatgtgca agatcataac aaaaacagtt 5581 aacagctttt gtaatatttt gaatatgccc aacatataaa attcaaacgt aaaatcaaat 5641 cgatttacat aaacaatgaa tacatataaa agtgtactgc acgattttat ctaaatagag 5701 cacaaaaaga caaagcggta gaaaataact tgaaagtaaa ataatatata tatcatatac 5761 atatatatat atcatataca tatcctaata tatggcaatt taaactaagt aagcaactga 5821 atctaaat