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Drosophila melanogaster Nna1 carboxypeptidase (Nna1), transcript


LOCUS       NM_176726               4446 bp    mRNA    linear   INV 26-DEC-2023
            variant C, mRNA.
ACCESSION   NM_176726
VERSION     NM_176726.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4446)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4446)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4446)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4446)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4446)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4446)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4446)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4446)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4446)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4446)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4446)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4446)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4446)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4446)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4446)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4446)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4446)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4446)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4446)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4446)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4446)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4446)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4446)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On May 8, 2012 this sequence version replaced NM_176726.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4446
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4446
                     /gene="Nna1"
                     /locus_tag="Dmel_CG44533"
                     /old_locus_tag="Dmel_CG32627"
                     /old_locus_tag="Dmel_CG32628"
                     /gene_synonym="CG11428; CG32627; CG32628; CG44533;
                     Dmel\CG44533; Nnad; NnaD"
                     /note="Nna1 carboxypeptidase"
                     /map="12B3-12B4"
                     /db_xref="FLYBASE:FBgn0265726"
                     /db_xref="GeneID:32329"
     CDS             921..3662
                     /gene="Nna1"
                     /locus_tag="Dmel_CG44533"
                     /old_locus_tag="Dmel_CG32627"
                     /old_locus_tag="Dmel_CG32628"
                     /gene_synonym="CG11428; CG32627; CG32628; CG44533;
                     Dmel\CG44533; Nnad; NnaD"
                     /EC_number="3.4.17.-"
                     /note="CG44533 gene product from transcript CG44533-RC;
                     CG44533-PC; Nna1-PC; drosophila Nna1 ortholog"
                     /codon_start=1
                     /product="Nna1 carboxypeptidase, isoform C"
                     /protein_id="NP_788899.1"
                     /db_xref="FLYBASE:FBpp0309515"
                     /db_xref="GeneID:32329"
                     /db_xref="FLYBASE:FBgn0265726"
                     /translation="MRLAGGGECAPGKLNSVSKMINNVDNRSTSASLDDNDDYYDDEY
                     DTSGGYCGGSGEAKEKAIIKDLIEAKKKRYQEEAEVTPVGGGTARNSRAASRSEASKD
                     ASDIDDIWKNNTSEYKPASPRYVLSQFGKNVTKAVIDRIVDHEDLVPPSGSQKVSNQF
                     AVGPVKLPKTNIARLEVAFERSACQDRSKSRLKKKMSSSRRRRESTSDEDSSSSSLGN
                     EEDEEVDDSDSDAENTGSGIGLRRILGSYSARLAGGAEKCPCPGSGSVSDTETLVGDE
                     SRSRLAGSNGLHQQDVVCSRNRQAQSRSPLRSVPHTHAATVAAAAAALARGRNRDKDG
                     CLGGKDEKNMGMGVGTTGTSSMGTRTSSPVRNNVFRLSKDQHILLNSMTSQETTGTLI
                     SSTSTNQTTTTTNSSQSFLCSDLPQAQFSRSAVGGARFMTNCHPMNPEEYDGLEFESR
                     FESGNLAKAVQITPTYYELYLRPDLYTSRSKQWFYFRVRRTRRKMLYRFSIVNLVKSD
                     SLYNDGMQPVMYSTLGAKEKSEGWRRCGDNICYYRNDDESASSSANEDDEDNSTYTLT
                     FTIEFEHDDDTVFFAHSYPYTYSDLQDYLMEIQRHPVKSKFCKLRLLCRTLAGNNVYY
                     LTVTAPSSNEENMRRKKSIVVSARVHPSETPASWMMKGLMDFITGDTTVAKRLRHKFI
                     FKLVPMLNPDGVIVGNTRNSLTGKDLNRQYRTVIRETYPSIWYTKAMIRRLIEECGVA
                     MYCDMHAHSRKHNIFIYGCENKRNPEKKLTEQVFPLMLHKNSADRFSFESCKFKIQRS
                     KEGTGRIVVWMLGITNSYTIEASFGGSSLGSRKGTHFNTQDYEHMGRAFCETLLDYCD
                     ENPNKVKRHAKLFKQIKKIRKREKREQKALKLQKMADQGCIMNDKLKVKRSVEKSVS"
     misc_feature    2259..2666
                     /gene="Nna1"
                     /locus_tag="Dmel_CG44533"
                     /old_locus_tag="Dmel_CG32627"
                     /old_locus_tag="Dmel_CG32628"
                     /gene_synonym="CG11428; CG32627; CG32628; CG44533;
                     Dmel\CG44533; Nnad; NnaD"
                     /note="Cytosolic carboxypeptidase N-terminal domain;
                     Region: Pepdidase_M14_N; pfam18027"
                     /db_xref="CDD:407865"
     misc_feature    2730..3485
                     /gene="Nna1"
                     /locus_tag="Dmel_CG44533"
                     /old_locus_tag="Dmel_CG32627"
                     /old_locus_tag="Dmel_CG32628"
                     /gene_synonym="CG11428; CG32627; CG32628; CG44533;
                     Dmel\CG44533; Nnad; NnaD"
                     /note="Peptidase M14-like domain of ATP/GTP binding
                     protein AGBL-2 and AGBL-3, and related proteins; Region:
                     M14_AGBL2-3_like; cd06907"
                     /db_xref="CDD:349478"
     misc_feature    order(2868..2870,2877..2879,3018..3020,3045..3050,
                     3156..3161,3186..3188,3375..3377)
                     /gene="Nna1"
                     /locus_tag="Dmel_CG44533"
                     /gene_synonym="CG11428; CG32627; CG32628; CG44533;
                     Dmel\CG44533; Nnad; NnaD"
                     /note="active site"
                     /db_xref="CDD:349478"
ORIGIN      
        1 agtcaacaac aaaacgcgca acggcaaacg acaaaacaaa aaaatacaaa gaaaacacca
       61 ttcgaaatct caaaacaaaa ttgcaatata atcgaaccga attcataatt aaaaaaaaaa
      121 aaatcaaaga ctccaaataa aagacacatg aaattggaaa ttcgaaaact gagcattaga
      181 aacaaataag atccaaatac ctaaaaagtg tgccgccata aatcggtttt ctattgtcac
      241 ctttcagttt tgttttattg ttttctgttt gttcgagtgt cacaaatttt gaacatcgct
      301 gttcgaaaga ataacaaaat atcagcttat acgaacagct gtgtgagtgc tgccccccgt
      361 tttctcaccg cctccgccac ccaccacatt tagcgtcttc ttctgttttc gtttcgcttt
      421 tatcgcccgt gttccttttc gcgttttcga gatcgtttgg aggagcgagt tctaaattct
      481 ttgccggctt ccttggcagt ttcctatcga agggcctaaa gaccaatcag ctggttgtga
      541 atacggatga gaagaccctg cgaccagttg cacgtctgaa ggaaccgcgc gatctcttcg
      601 ccctgccgaa ggacaaggac aatgactgct cacagcaggc ccccagatgg ccggtggaat
      661 gccaggtcat cgaggagcgc atcatacaca ttccgtacgt gcccgctgtg ccggagccgc
      721 tcaatgctcc gacgggaaac gagctgaaac cgcgtcccgt tggcgaggag aacggcattg
      781 tggtgttcag ctacagtcca attagtgccg tcaactatga aaagcccaag gcgaagaagg
      841 aggacgatga gtccagcgac gaatcggact attcctcgga ctctcgccag gattcgacgc
      901 cgccgagccg atccacgccc atgcgcctgg ccggcggcgg tgaatgtgca cctggcaaac
      961 tgaacagcgt gtccaagatg atcaacaatg tggacaatcg gtcaaccagt gcgtccctag
     1021 acgacaacga tgactactac gatgatgagt acgatacgtc cggcggttat tgtggtggaa
     1081 gcggtgaggc caaagagaag gccatcatta aggatctcat cgaggcgaag aagaaacgct
     1141 accaggagga ggcagaggtc acacccgtag gtggtggcac agcccgaaat tcgagagccg
     1201 ccagccgttc ggaggccagc aaggatgcca gcgatatcga cgatatctgg aagaacaata
     1261 ccagcgaata taagccagcc tcgccgcgct acgtcctcag ccagtttgga aagaatgtga
     1321 ccaaggcggt gatcgatcgg atcgtggatc acgaagatct cgtcccgcca tcgggatccc
     1381 aaaaggtatc gaaccagttc gccgtaggcc ccgtcaagtt gcccaaaaca aatatagccc
     1441 gcttagaggt ggcctttgag cgaagtgcct gccaagatcg atccaaatcg cgtttgaaaa
     1501 agaaaatgag tagcagtcgt cggcgtaggg aaagcacctc tgacgaggac tccagtagct
     1561 ctagtttggg taatgaagaa gatgaagagg tggatgattc cgattcggac gcagagaata
     1621 caggaagtgg cattggcttg cgcagaatct tgggaagcta ttcggcccgt ctcgctggtg
     1681 gcgccgaaaa gtgtccttgt cccggttccg gatccgtttc ggatacggaa actttggtgg
     1741 gagacgagag caggagcagg ctggctggct ctaatggcct gcatcagcaa gatgttgtat
     1801 gctctaggaa tcggcaggcg caatcgcgat ccccattacg atcggtaccc cacacccatg
     1861 cggccactgt ggcggcggcg gcagcggcgc tcgccagggg gcgcaaccgc gacaaggacg
     1921 gttgtctggg tggcaaggat gaaaagaata tgggcatggg agtgggaaca actggcacaa
     1981 gctcgatggg cactcgcacc tcctctcccg ttcgcaataa cgtcttccgg ctgagtaagg
     2041 atcagcacat attgctgaat tcgatgacca gccaggagac gaccggcact ttaatctcgt
     2101 cgacaagtac taaccaaacg acgacgacca ccaactcgtc gcaatcgttt ctttgctccg
     2161 atttacccca agcgcagttt agccgttcgg ccgtcggtgg tgcccgcttc atgaccaatt
     2221 gccatcccat gaatccggag gagtacgatg gactggagtt tgaatcgcgc ttcgagagcg
     2281 gcaacctggc caaggcggtc caaattacgc ccacctacta cgagctctac ctgcgacccg
     2341 atctctatac cagccggtcc aagcaatggt tctacttccg tgtgcgacgc accaggcgca
     2401 agatgctcta ccgcttctcc attgtcaatc tggtgaagtc ggacagtctt tacaacgatg
     2461 gtatgcagcc ggtcatgtac tccacgctgg gcgccaagga gaagagcgaa ggctggcgca
     2521 gatgcggcga caacatctgc tactatcgga acgatgatga aagtgccagc agtagcgcca
     2581 acgaggatga cgaggacaac tccacataca cgctgacctt taccattgag ttcgagcacg
     2641 acgacgacac ggtgttcttt gcgcacagct atccgtacac ctatagcgac ctgcaggact
     2701 acctcatgga gatccaacgc catccggtca agtcaaagtt ctgcaagctg cgcctgctct
     2761 gccgcacctt ggctggcaat aatgtctact atctgacggt gacggcgccc tcatccaacg
     2821 aggagaacat gcggcggaag aaatcgattg tggtatcggc acgtgtccat cccagcgaga
     2881 cgccagcctc gtggatgatg aagggtctga tggacttcat caccggggac acaacagtgg
     2941 ccaagcggtt gcggcacaag ttcattttta aattggtgcc catgctaaat ccggacggag
     3001 tcattgtggg caatacacgt aactcgctga ccggcaagga cctgaaccgc cagtaccgaa
     3061 cggtaatacg cgagacatat ccatccattt ggtataccaa agccatgatt agaagactga
     3121 ttgaggaatg cggcgtggcc atgtactgtg atatgcacgc tcactcacgc aagcacaaca
     3181 tattcatata tggctgtgag aacaaacgca acccggagaa gaagttaacc gagcaggtct
     3241 ttccgctgat gctgcacaag aacagtgcgg atcggttctc cttcgagagc tgcaagttca
     3301 aaattcagcg cagcaaggag ggcaccggac gtatcgtggt ctggatgctg ggcatcacca
     3361 acagctatac gatcgaagcc tcctttggcg gctcctcgct gggatcgcgc aagggtacgc
     3421 acttcaacac gcaggattac gagcacatgg gacgagcatt ttgtgagaca cttctggact
     3481 actgcgatga gaatccgaac aaagtaaagc ggcacgcaaa gttgtttaaa caaatcaaaa
     3541 agataagaaa acgcgagaaa cgcgaacaga aagcattgaa attacagaaa atggccgatc
     3601 agggatgtat aatgaacgac aaattgaaag tgaaacgttc tgtggagaaa agtgtctcct
     3661 aggaaggttt tatcccatca atactagccc acaatataac tatcgacaca cacagctcga
     3721 aatccaaaca acaaaaacca cacatcgact tgtgccgttt cttttttttt ttatcgttct
     3781 tgaactatac tcgtaaatcg ttaatcgtca attgtcaatc gtatatcgtt tatcgcatag
     3841 agtaattgta atcgcaatta ttgttaccaa ctcgtcgctg cctgcgtttt gtccctaaag
     3901 cgctgctgtg ctgacccaga attcaaatcc caaatccaaa gccatcgaca ttatcgtaaa
     3961 tacaattcaa cacacaacaa atacacgtcg gccagaggta tataacagat atacatgtag
     4021 ctaaacgtat atctggtcat atacaccata tgcatatgtt atccaattaa cattacatgt
     4081 atatgaggca ttgaattgta tgaattttaa tgctctctat ttgcgcgtat cgcagttttt
     4141 ctaatgtttt tgagcactca gttgcgtggc tagtatatct ctatccacgc aatgggttct
     4201 tagattactt ctgtagatct atttatatat aatttcatat atacatacac ccacctgaat
     4261 ccgcacaatc ctaactatat agtgacacac agcacagcat cgccaggcac aataggtctt
     4321 ttatcttatc ctagtcgctc taactataat tcgcgtttct ttcgatgttg ctagtcgtaa
     4381 gcgtaaccgt attattataa ccggaaaata ttattttttg aaataaatac catatctatt
     4441 catatg