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Drosophila melanogaster tyramine beta hydroxylase, transcript


LOCUS       NM_176711               3772 bp    mRNA    linear   INV 26-DEC-2023
            variant B (Tbh), mRNA.
ACCESSION   NM_176711
VERSION     NM_176711.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3772)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3772)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3772)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3772)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3772)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3772)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3772)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3772)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3772)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3772)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3772)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3772)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3772)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3772)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3772)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3772)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3772)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3772)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3772)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3772)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3772)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3772)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3772)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_176711.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3772
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3772
                     /gene="Tbh"
                     /locus_tag="Dmel_CG1543"
                     /gene_synonym="CG1543; Dbh; DBH; Dmel\CG1543; T beta h;
                     tbetah; Tbetah; TbetaH; TBetah; TBetaH; TbetaM; tbh; TbH;
                     TBh; TBH"
                     /note="Tyramine beta hydroxylase"
                     /map="7D2-7D2"
                     /db_xref="FLYBASE:FBgn0010329"
                     /db_xref="GeneID:31718"
     CDS             215..2227
                     /gene="Tbh"
                     /locus_tag="Dmel_CG1543"
                     /gene_synonym="CG1543; Dbh; DBH; Dmel\CG1543; T beta h;
                     tbetah; Tbetah; TbetaH; TBetah; TBetaH; TbetaM; tbh; TbH;
                     TBh; TBH"
                     /EC_number="1.14.17.-"
                     /EC_number="1.14.17.1"
                     /note="CG1543 gene product from transcript CG1543-RB;
                     CG1543-PB; Tbh-PB; dopamine beta hydroxylase; tyrosine
                     beta hydroxylase; tyramine beta-hydroxylase;
                     Tyrosine-beta-hydroxylase; tyramine betahydroxylase;
                     tyramine beta-monooxygenase; tyroside beta-hydroxylase;
                     tyramine beta hydroxylase; tyramine-beta-hydroxylase"
                     /codon_start=1
                     /product="tyramine beta hydroxylase, isoform B"
                     /protein_id="NP_788884.1"
                     /db_xref="FLYBASE:FBpp0089042"
                     /db_xref="GeneID:31718"
                     /db_xref="FLYBASE:FBgn0010329"
                     /translation="MLKIPLQLSSQDGIWPARFARRLHHHHQLAYHHHKQEQQQQQQQ
                     QQQQQAKQKQKQNGVQQGRSPTFMPVMLLLLMATLLTRPLSAFSNRLSDTKLHEIYLD
                     DKEIKLSWMVDWYKQEVLFHLQNAFNEQHRWFYLGFSKRGGLADADICFFENQNGFFN
                     AVTDTYTSPDGQWVRRDYQQDCEVFKMDEFTLAFRRKFDTCDPLDLRLHEGTMYVVWA
                     RGETELALEDHQFALPNVTAPHEAGVKMLQLLRADKILIPETELDHMEITLQEAPIPS
                     QETTYWCHVQRLEGNLRRRHHIVQFEPLIRTPGIVHHMEVFHCEAGEHEEIPLYNGDC
                     EQLPPRAKICSKVMVLWAMGAGTFTYPPEAGLPIGGPGFNPYVRLEVHFNNPEKQSGL
                     VDNSGFRIKMSKTLRQYDAAVMELGLEYTDKMAIPPGQTAFPLSGYCVADCTRAALPA
                     TGIIIFGSQLHTHLRGVRVLTRHFRGEQELREVNRDDYYSNHFQEMRTLHYKPRVLPG
                     DALVTTCYYNTKDDKTAALGGFSISDEMCVNYIHYYPATKLEVCKSSVSEETLENYFI
                     YMKRTEHQHGVHLNGARSSNYRSIEWTQPRIDQLYTMYMQEPLSMQCNRSDGTRFEGR
                     SSWEGVAATPVQIRIPIHRKLCPNYNPLWLKPLEKGDCDLLGECIY"
     misc_feature    530..871
                     /gene="Tbh"
                     /locus_tag="Dmel_CG1543"
                     /gene_synonym="CG1543; Dbh; DBH; Dmel\CG1543; T beta h;
                     tbetah; Tbetah; TbetaH; TBetah; TBetaH; TbetaM; tbh; TbH;
                     TBh; TBH"
                     /note="DOMON domain; Region: DOMON; pfam03351"
                     /db_xref="CDD:460893"
     misc_feature    1007..1384
                     /gene="Tbh"
                     /locus_tag="Dmel_CG1543"
                     /gene_synonym="CG1543; Dbh; DBH; Dmel\CG1543; T beta h;
                     tbetah; Tbetah; TbetaH; TBetah; TBetaH; TbetaM; tbh; TbH;
                     TBh; TBH"
                     /note="Copper type II ascorbate-dependent monooxygenase,
                     N-terminal domain; Region: Cu2_monooxygen; pfam01082"
                     /db_xref="CDD:460053"
     misc_feature    1439..1909
                     /gene="Tbh"
                     /locus_tag="Dmel_CG1543"
                     /gene_synonym="CG1543; Dbh; DBH; Dmel\CG1543; T beta h;
                     tbetah; Tbetah; TbetaH; TBetah; TBetaH; TbetaM; tbh; TbH;
                     TBh; TBH"
                     /note="Copper type II ascorbate-dependent monooxygenase,
                     C-terminal domain; Region: Cu2_monoox_C; pfam03712"
                     /db_xref="CDD:461021"
ORIGIN      
        1 aaagccaagc taacgggaca aaagtcgcgc gcgactcgta agcttgttta ctttgccatt
       61 ataaatccgg cgggcgcttg tttgtgtttg tgttgatcag cagccatagc gaattaattt
      121 caaagtgttt ggctattagt gattagcgat aaacgatatc cgagaacaat aattccgcca
      181 ccgatctgcc ggccgtgcaa tctcaaatct caaaatgctt aaaattccgc tgcagctgag
      241 cagtcaggat ggcatttggc cagcccgatt cgccaggcga ctccatcacc accaccaact
      301 ggcttatcat catcacaagc aggagcagca gcagcagcag cagcagcagc agcagcagca
      361 ggcgaaacag aaacaaaagc aaaatggagt gcagcaagga cgttcgccga catttatgcc
      421 agtgatgctg ctcctcctaa tggccacact gctcacgcgc ccgctgagcg ccttctccaa
      481 ccgcttatcc gacacaaagc tgcacgagat ctacctggac gacaaggaga ttaagctgag
      541 ctggatggtc gactggtaca agcaggaggt gctcttccac ttgcagaatg ctttcaacga
      601 acagcaccgc tggttctatc tgggtttctc caagcgcggc ggcctggcgg atgcggatat
      661 ttgctttttt gagaatcaga atggattctt caatgcggta accgatacgt acaccagtcc
      721 ggatggacag tgggtgagac gggactacca gcaggactgt gaggtcttca agatggatga
      781 gttcacgttg gcgtttaggc gcaagtttga cacctgcgac cctttggatt tgcgactcca
      841 tgagggcaca atgtacgtgg tttgggcccg tggtgaaacg gaactggccc tggaggatca
      901 ccagttcgct ctgcccaatg tgacggcacc gcacgaggcg ggtgttaaga tgctacagct
      961 actacgggcc gacaagatac ttatacccga aaccgagttg gatcacatgg agatcacact
     1021 gcaggaggcg ccaattccca gtcaggagac cacgtactgg tgtcacgttc agcgactgga
     1081 gggcaatctc cggcgtcgcc atcatatcgt tcagttcgag ccgctcatcc gaacgccggg
     1141 catcgtgcat cacatggaag tgtttcactg cgaggccggt gagcacgagg agattcccct
     1201 gtacaacggc gactgtgaac agttgccgcc acgggccaag atctgctcaa aagtgatggt
     1261 cctgtgggcc atgggcgcgg gcacctttac ctatcctccg gaagccggtc taccaatcgg
     1321 cggacccggc ttcaatccgt acgttcgact ggaggtacat ttcaataatc cggagaagca
     1381 gtcgggcttg gtggacaact ccggctttcg catcaagatg tcgaagacac tgcgtcagta
     1441 tgacgccgcc gttatggaac tgggtctgga gtacaccgac aaaatggcca ttccgcctgg
     1501 ccaaaccgct ttcccgctga gcggctattg tgtggcggac tgcacacgag ccgctctgcc
     1561 ggcgacgggc atcatcatct ttggctctca gctgcatacg catctgcgtg gcgttcgcgt
     1621 cctaacccgg cactttcgcg gcgaacagga gctgcgcgag gtgaaccgcg atgactacta
     1681 ctcgaatcac ttccaggaga tgcgcaccct gcactacaag ccgcgtgtcc tgcccggcga
     1741 cgctttggta accacttgtt actacaatac caaggatgac aagaccgccg ccctcggcgg
     1801 attctccatc agcgatgaga tgtgcgtcaa ctatatccac tactatccgg ccaccaaact
     1861 ggaggtctgc aagagttccg tttccgagga gacgctcgag aattacttta tttacatgaa
     1921 gcgcacggag catcagcatg gcgtgcattt gaatggagcc aggtcgtcca attaccggag
     1981 catcgaatgg acccagccgc gtatcgatca gctgtacacc atgtacatgc aggagccgct
     2041 gagcatgcag tgcaacaggt ccgatggcac tcgcttcgag gggcggtcta gctgggaggg
     2101 cgtggctgcg acgcccgtac aaattcgcat acccattcac cgcaaactgt gccccaacta
     2161 caatccgctg tggctgaagc cattggagaa gggcgattgc gatttgctgg gggagtgcat
     2221 ctattagggg cgccgtacat taggcattag gcgaataggc gaatgggggc gtggcatagc
     2281 acacactcac acccacaccc acacacacac acacacatac agcacataca acacacgcgc
     2341 acggcatgga taatatgaga atttcgattt caacagtcgc ctatgcaaaa gctaaactca
     2401 ttcacgtcta ttttgaaagc ttaactcatg aatacttttg aatatttagc aaaaaaagct
     2461 tgaaaacaga tctaaaaaca tttaaaaaaa ggttatttta ctcctatttt ggttagttag
     2521 ttcttactaa cagtaactaa ctgatagcct aaatgtttct gttgacttta ctttgaaatt
     2581 cgcaacagaa atcagaggaa tcactttttt tttgttttgt tttttacgcc ttatggaagt
     2641 ttgactgtag tcgctttgta ttttaccctt tatctgcatg gtcattagca ttatcaacgc
     2701 gtttgtatgt gtgcgtgtgt gtgtgtgtgt gtgtgtgtaa gggcaacagg gcaaaacaaa
     2761 tgttttcact ctttaaataa ctaatgcatt taccaatcct gcccatgttg ttcacccttt
     2821 ttactttcac tttcactttg ctttcgcctt tgactttgtt tgtgcccttt gcccttgttg
     2881 ttttggccag cctttgaaat ttgccgactg acagcgccgc caggctagaa cgtttaatac
     2941 gacacagctt acaaagcatg gcccacacgc acacacacac acacacacac acaagcgcgc
     3001 gcgcacagaa acacacacac acaagcgcac tgaacttggc tgagacgaaa ctgtagcata
     3061 cttctcagcg ccagctgaaa aattaaatgg ccaactgact gaatgaaacg gaacgtactt
     3121 aaacggacaa actggccgga aacaagatgg ccaagaaatg gatggcggac tcactctgtt
     3181 tatacaatat aaatgagcaa acttttgatg caacccgacg ttgccaagtc taattaccaa
     3241 gaaactcggc gagaaagacg gacaaaaatc gaaagagaaa aaaatatata ttaaattggt
     3301 atgagatctt attggaaatg tgaaaagttg gcgcagaggg gatcatggga catggtagat
     3361 gggctaccaa cagccaggag cttaccacat gcacccatgt gtttctttca caaaaagggg
     3421 aatcctctag tcgccccatt cgattcccta ttaatccaac cctatcagta ccttcacgct
     3481 tttcttactt ttcactaccg ttgaacctat cgacataaat gcaccaacac atacacatcc
     3541 acacaaccac accgacatac atttgagtaa acatgtaatg gatacgttta agtgtagcca
     3601 acatacatat gtaagatgtg ataattgttc tatggctata aatgaaatat atatacacat
     3661 gaatatataa actatgtaga tgaaatattt ataaaaaaca aaaaccaagc gaaagcgaaa
     3721 ccaaaaaaaa agtaaaatgt ataattatct aataaaaact gaccaccata cc